NCT05298501

Brief Summary

The purpose of the study is to examine the properties of the Automatic Story Recall Test (ASRT) and its parallel variants, as well as letter fluency and category fluency cognitive tests. Tests will be completed in crowdsourced populations, to derive normative data, and examine test properties in demographically diverse and cognitively impaired participants recruited and tested online.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,034

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Apr 2022

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 17, 2022

Completed
11 days until next milestone

First Posted

Study publicly available on registry

March 28, 2022

Completed
8 days until next milestone

Study Start

First participant enrolled

April 5, 2022

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 8, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 8, 2022

Completed
Last Updated

January 31, 2024

Status Verified

March 1, 2022

Enrollment Period

3 months

First QC Date

March 17, 2022

Last Update Submit

January 29, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • Age, sex, and education adjusted normative scores for the Automatic Story Recall Task (ASRT) test variants derived via linear regression analysis.

    Participants will complete a story recall task (ASRT), which will be administered in triplets (3x stories) with immediate and delayed recall assessed. Six different test phases, recruiting different participant samples, will be completed in which six parallel ASRT triplets will be separately evaluated. Normative data will be generated for each test triplet.

    Baseline

Secondary Outcomes (9)

  • Normative data will be derived for shorter variants of the ASRT test battery derived via linear regression analysis.

    Baseline

  • Age, sex, and education adjusted normative scores for the category fluency task performance derived via linear regression analysis.

    Baseline

  • Age, sex, and education adjusted normative scores for the letter fluency task performance derived via linear regression analysis.

    Baseline

  • The effect of demographic differences on task performance will be evaluated via linear regression analysis.

    Baseline

  • Demographic and cultural biases will be examined via group or pairwise comparison of transcription error rate and scoring errors on a simple reading task.

    Baseline

  • +4 more secondary outcomes

Study Arms (3)

AMYWEB-Normative

This cohort assessed over six recruitment and test phases, will be sampled to be as closely representative of the demographic population as possible.

Other: No intervention/exposure

AMYWEB-Diversity

This cohort assessed over two recruitment and test phases will oversample participants from minority and mixed ethnic and racial backgrounds as well as participants from lower educational backgrounds.

Other: No intervention/exposure

AMYWEB-MCI

This cohort assessed and recruited over one test phase, will include participants with a reported diagnosis of mild cognitive impairment or dementia.

Other: No intervention/exposure

Interventions

No interventions/exposures will be administered or evaluated

AMYWEB-DiversityAMYWEB-MCIAMYWEB-Normative

Eligibility Criteria

Age18 Years+
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Participants will be recruited online, primarily through crowdsourcing websites.

You may qualify if:

  • First language must be English
  • Residing in the USA
  • Willing to participate in a study investigating speech and dementia
  • Able to provide informed consent
  • Access to personal computing device that is capable of audio and video recording, and able to connect to the internet
  • Since key research questions are focused primarily on older-age speech and cognition, initial recruitment will be focused on older adult age brackets, which may be extended to younger adulthood if the desired sample sizes are not attained.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Novoic Ltd

London, United Kingdom

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition DisordersNeurocognitive DisordersMental Disorders

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
CROSS SECTIONAL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 17, 2022

First Posted

March 28, 2022

Study Start

April 5, 2022

Primary Completion

July 8, 2022

Study Completion

July 8, 2022

Last Updated

January 31, 2024

Record last verified: 2022-03

Locations