The Impact of Choice on Colorectal Cancer Screening
CRC45+
1 other identifier
interventional
20,509
1 country
2
Brief Summary
In May of 2021, the United States Preventive Service Task Force (USPSTF) updated their colorectal cancer (CRC) screening guidelines by recommending screening at an earlier age for average-risk adults starting at the age of 45 years old (Grade B recommendation). This is in addition to their Grade A recommendations of continuing to screen average-risk adults ages 50-75 years old. UCLA Health previously implemented a fecal immunochemical test (FIT) outreach program wherein FIT kits are mailed to average-risk patients overdue for CRC screening twice annually to promote screening uptake. As the investigators health system aims to screen the newly eligible population of average-risk patients between the ages of 45-49, the investigators proposed randomized controlled trial is aimed to determine the most effective patient outreach approach to maximize screening uptake within this age-group.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable colorectal-cancer
Started Feb 2022
Shorter than P25 for not_applicable colorectal-cancer
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 19, 2022
CompletedStudy Start
First participant enrolled
February 21, 2022
CompletedFirst Posted
Study publicly available on registry
March 11, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 21, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
November 21, 2022
CompletedNovember 13, 2023
November 1, 2023
6 months
February 19, 2022
November 9, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Overall completion of any Colorectal Cancer Screening test
Rate of completion of any CRC screening (FIT Kit or Colonoscopy) throughout the observation window.
6 months after getting the text message
Secondary Outcomes (3)
Selection of modality in MyChart Survey
within 4 weeks from receiving the initial MyChart message
CRC screening order placed by any modality
within 6 weeks from receiving the initial MyChart message
Colorectal cancer screening uptake by modality
6 months after getting the initial MyChart message
Study Arms (4)
Standard of Care
NO INTERVENTIONNo Intervention-"Standard Care" UCLA Health has a mailed FIT outreach program. This group will receive standard FIT mailer protocol. They will receive a tailored MyChart message indicating the importance of CRC screening and not be presented with a choice for screening modalities.
FIT Choice
EXPERIMENTALThis group will receive a tailored message via MyChart with information about CRC screening and using the FIT kit for noninvasive screening. They will then have to actively choose if they want CRC screening with a FIT kit vs no screening. If they opt for screening, the investigators will mail them a FIT kit.
Colonoscopy Choice
EXPERIMENTALThis group will receive a tailored message via MyChart with information about CRC screening and colonoscopy for CRC screening. They will then have to actively choose if they want CRC screening with a colonoscopy vs no screening. If they opt for screening, the investigators will direct them to our patient navigators to get scheduled for a colonoscopy.
Dual Choice
EXPERIMENTALThis group will receive a tailored message via MyChart with information about CRC screening and using either the FIT kit or colonoscopy for CRC screening. They will then have to actively choose if they want CRC screening with a FIT kit, a colonoscopy, or no screening. If they opt for screening, the investigators will either mail them a FIT kit or direct them to our patient navigators to schedule a colonoscopy, depending on their choice.
Interventions
The investigators will send randomized participants a message via MyChart indicating the benefits of CRC screening, along with tailored information about FIT as a screening strategy. At the end of the message, participants will complete a survey asking them to indicate if they would like to be screened for CRC with a FIT, or if they prefer no screening whatsoever. The investigators will then ask follow-up questions to better understand the reason patients made their respective choices.
The investigators will send randomized participants a message via MyChart indicating the benefits of CRC screening, along with tailored information about colonoscopy as a screening strategy. At the end of the message, participants will complete a survey asking them to indicate if they would like to be screened for CRC with a colonoscopy, or if they prefer no screening whatsoever. The investigators will then ask follow-up questions to better understand the reason patients made their respective choices.
The investigators will send randomized participants a message via MyChart indicating the benefits of CRC screening, along with tailored information about FIT Kit and Colonoscopy screening. At the end of the message, participants will complete a survey asking them to indicate if they would like to be screened for CRC with either a FIT or Colonoscopy, or if they prefer no screening whatsoever. The investigators will then ask follow-up questions to better understand the reason patients made their respective choices.
Eligibility Criteria
You may qualify if:
- UCLA Health patient
- Age 45-49 (as of 1/1/2022)
- Active primary care provider at UCLA Health
- Visit within the last 3 years
You may not qualify if:
- Age \<45 or \>50 years old at time of randomization
- Documented family history of CRC in EMR
- History (personal or family) of prior adenomatous polyps in the EHR
- History of high-risk cancer syndromes (e.g., Lynch, FAP)
- Prior CRC screening with colonoscopy or FIT
- Inactive MyChart status at enrollment
- No documented SMS-capable phone number
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
UCLA Health Department of Medicine, Quality Office
Los Angeles, California, 90095, United States
UCLA Vatche and Tamar Manoukian Division of Digestive Diseases
Westwood, Los Angeles, California, 90095, United States
Related Publications (1)
Galoosian A, Dai H, Croymans D, Saccardo S, Fox CR, Goshgarian G, De Silva S, Han MA, Vangala S, May FP. Population Health Colorectal Cancer Screening Strategies in Adults Aged 45 to 49 Years: A Randomized Clinical Trial. JAMA. 2025 Sep 2;334(9):778-787. doi: 10.1001/jama.2025.12049.
PMID: 40758331DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Medical Director, DOM Quality
Study Record Dates
First Submitted
February 19, 2022
First Posted
March 11, 2022
Study Start
February 21, 2022
Primary Completion
August 21, 2022
Study Completion
November 21, 2022
Last Updated
November 13, 2023
Record last verified: 2023-11
Data Sharing
- IPD Sharing
- Will not share
We do not plan to make any individual participant data available.