Pulse Wave Velocity and Hemodynamic Response During Anesthesia Induction in Hypertensive Patients

NCT05155514 | Completed

• 1 other identifier: Arterial stiffness
• Study Type: observational
• Target: 139
• Locations: 1 country
• Sites: 1

Brief Summary

Hypertension is a disease with increasing and serious complications all over the world. In particular, the incidence of hypertension increases with advancing age. Secondary problems that can be caused by hypertension include peripheral vascular diseases, arteriosclerosis, increased risk of heart attack and stroke. It is a measurement of pulse wave velocity (PWV), a non-invasive indicator of arterial stiffness. It is known that sudden hemodynamic changes that occur during the induction of anesthesia cause undesirable intraoperative and postoperative complications. It is known that arterial stiffness, which is more common in elderly patients, causes orthostatic hypotension in particular. For this reason, more hemodynamic instability may be seen in the general anesthesia procedure in elderly patients with increased arterial stiffness. In our study, we aimed to investigate whether the hemodynamic changes observed during anesthesia induction in hypertensive elderly patients, whom we think have a high pulse wave velocity, are different from normotensive patients.

Conditions

Arterial Stiffness

Outcome Measures

Primary Outcomes (1)

• Difference between hemodynamic values

  The difference between the hemodynamic values measured preoperatively and during anesthesia induction was calculated. In addition, ≥20% decrease in preoperative hemodynamic value and/or systolic blood pressure ≤90 mmHg hypotension, ≥20% increased hypertension

  Basal measurement before induction of anesthesia, then at 1-minute intervals until after endotracheal intubation

Study Arms (2)

Group H

Hypertension group (Group H): * Patients with a previous diagnosis of hypertension * Patients receiving antihypertensive therapy * Systolic blood pressure (SBP) ≥140mmHg and/or diastolic blood pressure (DBP) ≥90mmHg

Procedure: Mobil-O-Graph PWA

Group N

Normotensive group (Group N): Other non-hypertensive patients

Procedure: Mobil-O-Graph PWA

Interventions

Mobil-O-Graph PWA PROCEDURE

After resting in a quiet room preoperatively, blood pressure was measured on the right arm using an oscillometric method.

Group H; Group N

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All Patients aged 50 and over

You may qualify if:

• According to the American Society of Anesthesiologists (ASA), physical condition I-II,
• Elective otolaryngology surgery with endotracheal intubation planned
• Patients aged 50 and over

You may not qualify if:

• Hypersensitivity to drugs
• Difficult intubation history
• Diabetes mellitus receiving insulin therapy
• Chronic renal failure or end-stage renal disease
• Heart failure (left ventricular ejection fraction ≤30%)
• Valve disease (moderate to severe)
• Atrial fibrillation

Sponsors & Collaborators

• Aydin Adnan Menderes University: lead

Study Sites (1)

Aydın Adnan Menderes University Faculty of Medicine, Department of Anesthesiology and Reanimation

Aydin, 09100, Turkey (Türkiye)

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: December 3, 2021
• First Posted: December 13, 2021
• Study Start: November 1, 2018
• Primary Completion: November 1, 2019
• Study Completion: November 1, 2020
• Last Updated: December 13, 2021

Record last verified: 2021-12

Locations

TU (1)