Comparison of PD1+T Cell Expression in Peripheral Blood for Cardiac Function Prognosis in Patients With Acute MI

NCT05251987 | Unknown DMC

• 1 other identifier: 2021-0725
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Comparison of high PD1+ T cell and low PD1+ T cell expression in peripheral blood for cardiac function prognosis in Patients with acute myocardial infarction

Conditions

PD1; Acute Myocardial Infarction

Outcome Measures

Primary Outcomes (1)

• Cardiac function(echocardiography) recovery after 1 and 3 months was measured compared with baseline(at admission).

  Compare the changes of ejection fraction（%） at 1 and 3 months with baseline(at admission)

  at admission, 1 month , 3 months

Secondary Outcomes (1)

• Patient-oriented composite outcome

  3 months

Study Arms (2)

High PD1+ T Cell Expression

high PD1+ T cell expression in peripheral blood

Biological: PD1+ T Cell Expression

Low PD1+ T Cell Expression

low PD1+ T cell expression in peripheral blood

Biological: PD1+ T Cell Expression

Interventions

PD1+ T Cell Expression BIOLOGICAL

The expression of PD1+ T cells was detected by flow cytometry in peripheral blood

High PD1+ T Cell Expression; Low PD1+ T Cell Expression

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted to the department of Cardiology with a diagnosis of ST-segment elevation acute myocardial infarction, angiography indicating 50% stenosis of at least one major coronary artery and stent implantation were selected

You may qualify if:

• Over 18 years of age;
• Understand oral confirm to accept the risks and benefits of this experiment could bring He (she) or its legal representative in experiment related to provide written informed consent before surgery;
• Was diagnosed with st-elevation acute myocardial infarction;
• Based on the visual assessment of coronary angiography of coronary artery stenosis degree is 50% and the row stenting patients;
• The target vessels are limited to the main coronary arteries (including the left anterior descending, left circumflex, and right coronary arteries).

You may not qualify if:

• Pregnant or lactating women; Patients with previous malignant tumors or mental diseases; Recent major trauma/trauma, or surgical treatment; Drug, drug and alcohol abusers; Those who have been receiving antitumor drugs, immunosuppressants, hormones and antibiotics for a long time; People with blood-borne infectious diseases (including hepatitis B, c, syphilis, AIDS, etc.);
• People with immune deficiency diseases or autoimmune diseases; Liver and kidney dysfunction; Aortic dissection, pulmonary embolism, acute myocarditis or severe valvular disease; One who is in the acute phase of any illness (influenza, pneumonia, gastroenteritis, skin disease, etc.).

Sponsors & Collaborators

• Second Affiliated Hospital, School of Medicine, Zhejiang University: lead
• First People's Hospital of Hangzhou: collaborator

Study Sites (1)

The Second Affiliated Hospital of Zhejiang University, School of Medicine

Hangzhou, Zhejiang, China

RECRUITING

Study Officials

• Jianan Wang, MD, PhD

  2nd Affiliated Hospital, School of Medicine at Zhejiang University

  STUDY CHAIR

• Xinyang Hu, MD, PhD

  2nd Affiliated Hospital, School of Medicine at Zhejiang University

  STUDY DIRECTOR

Central Study Contacts

Jianan Wang, MD, PhD

CONTACT

+86 0571 87784808; wangjianan111@zju.edu.cn

Changle Ke, PhD

CONTACT

+86 15757102667; keheart@zju.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 17, 2022
• First Posted: February 23, 2022
• Study Start: October 1, 2021
• Primary Completion: June 1, 2022
• Study Completion: December 30, 2022
• Last Updated: February 23, 2022

Record last verified: 2021-10

Locations

CN (1)