the Association of Intestinal Microbial Metabolites and Cardiac Function in Acute Myocardial Infarction

NCT04955054 | Unknown

• 1 other identifier: M2020362
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Recently, more and more studies have confirmed that intestinal flora is closely related to the occurrence and development of cardiovascular diseases.Bile acids (BAS), short chain fatty acids (SCFA) and trimethylamine oxide (TMAO), the main metabolites of intestinal flora, are the key mediators of the interaction between gut and host. We aim to explore the association of BAs and SCFA with cardiac function in patients with AMI.

Conditions

Acute Myocardial Infarction

Keywords

bile acids; short chain fatty acid; cardiac function

Outcome Measures

Primary Outcomes (1)

• the plasma levels of BAs and SCFA

  the plasma levels of bile acids and short chain fatty acid in fast

  one week

Study Arms (3)

control

patients without coronary artery disease

UAP

patients without unstable angina pectoris

Diagnostic Test: diagnose

AMI

patients with acute myocardial infarction

Diagnostic Test: diagnose

Interventions

diagnose DIAGNOSTIC_TEST

Patients from UAP and AMI meet the criteria of UAP or STEMI.

AMI; UAP

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The patient, aged 18-85 years, had undergone coronary angiography and agreed to be enrolled and signed the informed consent. And they met the inclusion criteria and did not meet the exclusion criteria.

You may qualify if:

• The patient, aged 18-85 years, had undergone coronary angiography and agreed to be enrolled and signed the informed consent.
• AMI : according to ST segment elevation myocardial infarction diagnostic criteria.
• UAP:
• typical chest pain symptoms;
• negative in markers of myocardial injury;
• The stenosis of main coronary artery or its main branches is more than 50%
• Control:
• atypical chest pain symptoms
• negative in markers of myocardial injury;
• The stenosis of main coronary artery and its main branches is less than 50%

You may not qualify if:

• Acute infection or application of antibiotics in the past 3 months;
• Chronic heart failure;
• History of inflammatory or absorptive bowel disease and bowel resection;
• Acute, chronic liver disease or other reasons lead to abnormal liver function (transaminase is more than 5 times of normal value);
• Renal insufficiency (serum creatinine \> 220μml/L or creatinine clearance rate \< 30 ml/min);
• Malignant tumor;
• Autoimmune diseases;
• Uninformed patients

Sponsors & Collaborators

• Peking University Third Hospital: lead

Study Sites (1)

Peking University Third Hospital

Beijing, Beijing Municipality, 100191, China

RECRUITING

MeSH Terms

Interventions

Diagnosis

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 29, 2021
• First Posted: July 8, 2021
• Study Start: October 11, 2020
• Primary Completion: October 11, 2025
• Study Completion: December 31, 2025
• Last Updated: July 8, 2021

Record last verified: 2021-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)