Study Stopped
Closure of IMV operations
Closure of IMV operations
AVALON
Phase 2b Single Arm Study of Maveropepimut-S and Low-Dose Cyclophosphamide in Subjects With Platinum-Resistant, Epithelial Ovarian Cancer.
Sponsor study identifier
interventional
16
3 countries
6
Study Start
August 5, 2022
Actual (reported)Primary Completion
July 24, 2023
Actual (reported)Study Completion
August 31, 2023
Actual (reported)Phase 2, single arm, study to assess the efficacy and safety of maveropepimut-S (MVP-S) and low-dose cyclophosphamide (CPA) in subjects with recurrent, platinum resistant ovarian cancer.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 31, 2023
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 7, 2022
Actual (reported)February 17, 2022
Actual (reported)August 5, 2022
Actual (reported)July 24, 2023
Actual (reported)August 31, 2023
Actual (reported)Objective Response Rate (ORR)
per RECIST v1.1 criteria
up to 13 months
Objective Response Rate (ORR)
up to 13 months
Duration of Response (DOR)
up to 23 months
Disease Control Rate (DCR)
up to 13 months
Time to Progression (TTP)
up to 23 months
Progression Free Survival (PFS)
up to 23 months
Cell mediated immune response
up to 13 months
Changes in Tumor Micro-environment (TME)
up to 2 months
All subjects will receive two doses of maveropepimut-S (q3w) followed by up to six doses (q8w) plus low-dose cyclophosphamide on a repeating cycle of one week on/one week off.
SC injection on days 7, 28, then q8w
Stanford Health Care
Palo Alto, California, 94305, United States
Ocala Oncology
Ocala, Florida, 34474, United States
NYU Langone Hospital-Long Island
Mineola, New York, 11501, United States
NYU Langone: Laura and Isaac Perlmutter Cancer Center
New York, New York, 10016, United States
CHUM - Centre hospitalier de l'Université de Montréal
Montreal, Quebec, H2X 0A9, Canada
PanOncology Trials
San Juan, 00935, Puerto Rico
16 participants (actual enrollment reported by the registry).
First Submitted
February 7, 2022
First Posted
February 17, 2022
Study Start
August 5, 2022
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
July 24, 2023
Actual (reported)Study Completion
August 31, 2023
Actual (reported)Last Updated
September 13, 2023
Record last verified: 2023-09
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Source: ClinicalTrials.gov.
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