NCT05233176

Brief Summary

The primary objective of the study focuses on the kinetics of plasma CRP measured during the overall management (before the angioplasty procedure until the discharge of hospitalization) of patients with ST+ ACS requiring emergency transluminal angioplasty.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
35

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Mar 2022

Typical duration for all trials

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 28, 2022

Completed
13 days until next milestone

First Posted

Study publicly available on registry

February 10, 2022

Completed
20 days until next milestone

Study Start

First participant enrolled

March 2, 2022

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2024

Completed
Last Updated

October 1, 2025

Status Verified

September 1, 2025

Enrollment Period

2.1 years

First QC Date

January 28, 2022

Last Update Submit

September 29, 2025

Conditions

Keywords

acute coronary syndromeC reactive proteinkineticadults

Outcome Measures

Primary Outcomes (1)

  • Plasma CRP kinetic

    Blood sampling: Pre-angioplasty, on H6, H12, H24, H48 and once a day post angioplasty until the 7th day; then once a week until discharge from hospital with a maximum of 30 days

    Pre-angioplasty, hour 6, hour 12, hour 24, hour 48 and daily post angioplasty until day 7 then weekly untill day 30

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adult patients cared for ST+ ACS requiring emergency transluminal angioplasty.

You may qualify if:

  • Age over 18 years old;
  • ST+ ACS requiring emergency transluminal angioplasty;
  • Affiliation to a social security scheme or beneficiary.

You may not qualify if:

  • ST+ ACS not requiring emergency transluminal angioplasty;
  • Pregnancy;
  • Under guardianship or curatorship;
  • Foreign patient under french AME scheme.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Cardiology department, Ambroise Paré hospital, APHP

Boulogne-Billancourt, 92100, France

Location

Intensive care unit, Ambroise Paré hospital, APHP

Boulogne-Billancourt, 92100, France

Location

Related Publications (1)

  • Milwidsky A, Ziv-Baran T, Letourneau-Shesaf S, Keren G, Taieb P, Berliner S, Shacham Y. CRP velocity and short-term mortality in ST segment elevation myocardial infarction. Biomarkers. 2017 May-Jun;22(3-4):383-386. doi: 10.1080/1354750X.2017.1279218. Epub 2017 Jan 25.

    PMID: 28055283BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

C reactive protein (CRP) sampling

MeSH Terms

Conditions

Acute Coronary Syndrome

Condition Hierarchy (Ancestors)

Myocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular Diseases

Study Officials

  • Romain Jouffroy, MD, PhD

    Intensive Care Unit - Ambroise Paré Hospital - APHP

    PRINCIPAL INVESTIGATOR
  • Marie Hauguel-Moreau, MD

    Cardiology department, Ambroise Paré hospital, APHP

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 28, 2022

First Posted

February 10, 2022

Study Start

March 2, 2022

Primary Completion

April 1, 2024

Study Completion

April 1, 2024

Last Updated

October 1, 2025

Record last verified: 2025-09

Data Sharing

IPD Sharing
Will not share

Locations