NCT05218278

Brief Summary

To investigate the pharmacodynamics of light chain of NFL in patients with out-of hospital cardiac arrest after successful resuscitation and determine the difference in the serum levels of NFL in patients with favorable neurological outcome compared to those with non-favorable neurological outcome.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for all trials

Timeline
8mo left

Started Jan 2022

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress87%
Jan 2022Dec 2026

Study Start

First participant enrolled

January 1, 2022

Completed
16 days until next milestone

First Submitted

Initial submission to the registry

January 17, 2022

Completed
15 days until next milestone

First Posted

Study publicly available on registry

February 1, 2022

Completed
4.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2026

Last Updated

March 30, 2025

Status Verified

March 1, 2025

Enrollment Period

5 years

First QC Date

January 17, 2022

Last Update Submit

March 25, 2025

Conditions

Out-Of-Hospital Cardiac ArrestNeurological Injury

Outcome Measures

Primary Outcomes (1)

  • The difference in the dynamics of serum NFL levels measurements in patients with favorable neurological outcome compared to patients with non-favorable neurological outcome

    NFL levels

    3 years

Study Arms (2)

Patients with favorable neurlogical outcome

CPC 1/2

Patients with non-favorable neurological outcome

CPC3-5

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with non-traumatic out-of-hospital cardiac arrest successfully resuscitated and admitted to the ICU.

You may qualify if:

  • out-of-hospital cardiac arrest successfully resuscitated and admitted to the ICU

You may not qualify if:

  • trauma, drowning, electrocution, less than 18 years of age,

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University medical center Maribor

Maribor, 2000, Slovenia

RECRUITING

MeSH Terms

Conditions

Out-of-Hospital Cardiac ArrestTrauma, Nervous System

Condition Hierarchy (Ancestors)

Heart ArrestHeart DiseasesCardiovascular DiseasesNervous System DiseasesWounds and Injuries

Study Officials

  • Matej Strnad, MD, PhD

    University medical cenetr Maribor

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Matej Strnad, MD, PhD

CONTACT

+38651225448strnad.matej78@gmail.com

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Proffessor

Study Record Dates

First Submitted

January 17, 2022

First Posted

February 1, 2022

Study Start

January 1, 2022

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2026

Last Updated

March 30, 2025

Record last verified: 2025-03

Locations

SL(1)