NCT05211947

Brief Summary

This study is open to adults with schizophrenia who took part in a previous CONNEX study (study 1346-0011, 1346-0012, or 1346-0013). The purpose of this study is to find out how well people with schizophrenia can tolerate a medicine called Iclepertin in the long term. Participants take Iclepertin as tablets once a day for 1 year. In addition, all participants take their normal medication for schizophrenia. Participants are in the study for a little more than 1 year. During this time, they visit the study site about 13 times and get about 9 phone calls from the study team. The doctors collect information on any health problems of the participants. Doctors also regularly check the participants' symptoms of schizophrenia.

Trial Health

68
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
1,356

participants targeted

Target at P75+ for phase_3 schizophrenia

Timeline
Completed

Started Mar 2022

Typical duration for phase_3 schizophrenia

Geographic Reach
38 countries

300 active sites

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 14, 2022

Completed
13 days until next milestone

First Posted

Study publicly available on registry

January 27, 2022

Completed
2 months until next milestone

Study Start

First participant enrolled

March 21, 2022

Completed
2.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 26, 2025

Completed
20 days until next milestone

Study Completion

Last participant's last visit for all outcomes

March 18, 2025

Completed
1.1 years until next milestone

Results Posted

Study results publicly available

April 8, 2026

Completed
Last Updated

April 8, 2026

Status Verified

March 1, 2026

Enrollment Period

2.9 years

First QC Date

January 14, 2022

Results QC Date

February 20, 2026

Last Update Submit

March 30, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Occurence of Treatment Emergent Adverse Events (TEAEs)

    Number of participants with treatment emergent adverse events.

    From first until last drug administration plus residual effect period. Up to a maximum of 61.9 weeks.

Secondary Outcomes (2)

  • Change From Baseline in Clinical Global Impressions - Severity (CGI-S) to End of Treatment (EOT)

    At baseline and at EOT. Up to a maximum of 60.1 weeks.

  • Change From Baseline in Haemaglobin (Hb) to End of Treatment (EOT)

    At baseline and at EOT. Up to a maximum of 60.1 weeks.

Study Arms (1)

Iclepertin 10 mg

EXPERIMENTAL

Participants who received either placebo or iclepertin in the parent trials 1346-0011, 1346-0012, or 1346-0013 took a 10-milligram (mg) tablet of iclepertin once daily.

Drug: Iclepertin

Interventions

One 10 milligram (mg) tablet once daily.

Also known as: BI 425809
Iclepertin 10 mg

Eligibility Criteria

Age18 Years - 51 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Signed and dated written informed consent.
  • Clinically stable outpatients who have been diagnosed with schizophrenia (as per Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-5)).
  • Patients, who completed participation in the parent trial.
  • Women of childbearing potential must use highly effective methods of birth control.

You may not qualify if:

  • Participant who developed DSM-5 diagnosis other than Schizophrenia or any condition that would prevent the patient from participating in the extension trial since enrolment into the parent phase III trial.
  • Any suicidal behavior and/or suicidal ideation of type 5 based on the Columbia Suicidality Severity Rating Scale (C-SSRS) in parent trial and up to and including Visit 1 of this study.
  • Positive urine drug screen ≥ 3 times during the treatment period of parent trial.
  • Patients who are currently or wish to participate in another investigational drug trial.
  • Any clinically significant finding or condition in the judgment of the investigator that would jeopardize the patient´s safety while participating in the trial or their capability to participate in the trial.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (303)

Advanced Research Center, Inc.

Anaheim, California, 92805, United States

Location

Clinical Innovations, Inc

Bellflower, California, 90706, United States

Location

ProScience Research Group

Culver City, California, 90230, United States

Location

Collaborative Neuroscience Network, LLC (CNS)

Garden Grove, California, 92845, United States

Location

Omega Clinical Trials,LLC

La Habra, California, 90631, United States

Location

ASCLEPES Research Centers, P.C. dba Alliance Research

Long Beach, California, 90807, United States

Location

University of California Los Angeles

Los Angeles, California, 90095, United States

Location

ATP Clinical Research, Inc.

Orange, California, 92866, United States

Location

NRC Research Institute

Orange, California, 92868, United States

Location

CNRI - Los Angeles

Pico Rivera, California, 90660, United States

Location

Artemis Institute for Clinical Research, LLC

San Diego, California, 92103, United States

Location

Velocity Clinical Research, Santa Ana

Santa Ana, California, 92704, United States

Location

Stanford University Medical Center

Stanford, California, 94304, United States

Location

Collaborative Neuroscience Research

Torrance, California, 90504, United States

Location

Institute of Living

Hartford, Connecticut, 06106, United States

Location

Connecticut Mental Health Center

New Haven, Connecticut, 06519, United States

Location

Advanced Medical Research Group Inc

Hollywood, Florida, 33021, United States

Location

Accel Research Sites Network

Maitland, Florida, 32751, United States

Location

San Marcus Research Clinic, Inc.

Miami, Florida, 33014, United States

Location

CCM Clinical Research Group, LLC-Miami-68482

Miami, Florida, 33133, United States

Location

Optimus U Corporation-Miami-69452

Miami, Florida, 33135, United States

Location

University of Miami

Miami, Florida, 33136, United States

Location

Nova Psychiatry Inc.

Orlando, Florida, 32803, United States

Location

Synexus Clinical Research-Atlanta-67262

Atlanta, Georgia, 30328, United States

Location

American Medical Research

Chicago, Illinois, 60612, United States

Location

Sheppard Pratt Physicians's Practice Association, Inc.

Baltimore, Maryland, 21204, United States

Location

Center for Behavioral Health, LLC

Gaithersburg, Maryland, 20877, United States

Location

PsychCare Consultants Research

St Louis, Missouri, 63128, United States

Location

Arch Clinical Trials, LLC

St Louis, Missouri, 63141, United States

Location

Omaha Insomnia and Psychiatric Services

Omaha, Nebraska, 68144, United States

Location

Hassman Research Institute-Marlton-66897

Marlton, New Jersey, 08053, United States

Location

Neurobehavioral Research, Inc.

Cedarhurst, New York, 11516, United States

Location

New York State Psychiatric Institute

New York, New York, 10032, United States

Location

Richmond Behavioral Associates-Staten Island-68636

Staten Island, New York, 10314, United States

Location

UNC Center for Excellence in Community Mental Health, North Carolina Psychiatric Research Center

Raleigh, North Carolina, 27608, United States

Location

University of Cincinnati

Cincinnati, Ohio, 45219, United States

Location

Midwest Clinical Research

Dayton, Ohio, 45417, United States

Location

Insight Clinical Trials, LLC, Independence

Independence, Ohio, 44131, United States

Location

SP Research, PLLC

Oklahoma City, Oklahoma, 73112, United States

Location

University of Oregon Prevention Science Institute

Eugene, Oregon, 97403, United States

Location

Oasis Life Care

State College, Pennsylvania, 16801, United States

Location

Community Clinical Research, Inc.

Austin, Texas, 78754, United States

Location

Relaro Medical Trials, LLC

Dallas, Texas, 75243, United States

Location

InSite Clinical Research

DeSoto, Texas, 75115, United States

Location

JPS Center for Behavioral Health Recovery

Fort Worth, Texas, 76104, United States

Location

North Texas Clinical Trials

Fort Worth, Texas, 76104, United States

Location

Ben Taub General Hospital

Houston, Texas, 77030, United States

Location

LinQ Research, LLC-Richmond-70076

Richmond, Texas, 77407, United States

Location

Northwest Clinical Research Center

Bellevue, Washington, 98007, United States

Location

Clínica Privada Banfield

Banfield, B1828CKR, Argentina

Location

CENYDET-Centro Neurobiologico y de Estres Traumatico (Biopsychomedical Research Group S.R.L.)

CABA, 1058AAJ, Argentina

Location

Fundación para el Estudio y Tratamiento de las Enfermedades Mentales (FETEM)

CABA, C1133AAH, Argentina

Location

Fundación FunDaMos para la asistencia e investigación en psiquiatría

CABA, C1405BOA, Argentina

Location

CEN (Centro Especializado Neurociencias)

Córdoba, 5004, Argentina

Location

Instituto Modelo de Neurología Lennox

Córdoba, X5000FAL, Argentina

Location

Instituto Médico DAMIC S.R.L.

Córdoba, X5003DCE, Argentina

Location

Sanatorio Morra S.A.

Córdoba, X5009, Argentina

Location

Instituto de Neurociencias San Agustín

La Plata, 1900, Argentina

Location

Global Psy Asociación Civil

La Plata, CP B1904AXQ, Argentina

Location

Resolution Psychopharmacology Research Institute

Mendoza, 5502, Argentina

Location

Instituto Médico de la Fundación Estudios Clínicos

Rosario, 2000, Argentina

Location

Centro de Investigacion y Asistencia en Psiquiatria (CIAP)

Rosario, S2000QJI, Argentina

Location

Centro Medico Luquez

San Vicente, X5006CBI, Argentina

Location

Monash Alfred Psychiatry Research Centre

Melbourne, Victoria, 3004, Australia

Location

AKH - Medical University of Vienna

Vienna, 1090, Austria

Location

CUP Vivalia -La Clairière

Bertix, 6880, Belgium

Location

Sint-Kamillus

Bierbeek, 3360, Belgium

Location

Universitair Psychiatrisch Centrum Duffel (UPC Duffel)

Duffel, 2570, Belgium

Location

Meclinas

Mechelen, 2800, Belgium

Location

CPN - Centro de Estudos em Neurociências

Belo Horizonte, 30150-270, Brazil

Location

Hospital Sao Jose

Criciúma, 88811-000, Brazil

Location

Trial Tech- Tecnologia em pesquisa com medicamentos

Curitiba, 80.240-280, Brazil

Location

J A Serviços Médicos Ltda/ Instituto Goiano de Neuropisquiatria

Goiânia, 74093-040, Brazil

Location

Ruschel Medicina e Pesquisa Clínica

Rio de Janeiro, 22270-060, Brazil

Location

CEMEC - Centro Multidisciplinar de Estudos Clínicos

São Bernardo do Campo, 09780-000, Brazil

Location

Hospital de Base - Fac Med de Sao Jose do Rio Preto

São José do Rio Preto, 15090-000, Brazil

Location

Cpquali Pesquisa Clinica Ltda

São Paulo, 01228-000, Brazil

Location

BR Trials

São Paulo, 01236-030, Brazil

Location

Clínica Viver - Centro de Desospitalização Humana

São Paulo, 04020-060, Brazil

Location

Hospital das Clinicas da Faculdade de Medicina da USP

São Paulo, 05403-903, Brazil

Location

Medical Center "Spectar"

Plovdiv, 4000, Bulgaria

Location

Filipopolis Ambulatory for Group Practice for Specialized Care in Psychiatry

Plovdiv, 4002, Bulgaria

Location

University of Calgary

Calgary, Alberta, T2N 4Z6, Canada

Location

Centre for Addiction and Mental Health (CAMH)

Toronto, Ontario, M5T 1R8, Canada

Location

Biomedica Research Group

Santiago, 7500710, Chile

Location

Psicomed Estudios Clínicos

Segunda Región, 1270244, Chile

Location

The sixth People's Hospital of Hebei Province

Baoding, 71000, China

Location

Beijing Anding Hospital

Beijing, 100088, China

Location

Peking University Sixth Hospital

Beijing, 100089, China

Location

Beijing HuiLongGuan Hospital

Beijing, 100096, China

Location

The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province)

Changsha, 410007, China

Location

The Second Xiangya Hospital Of Central South University

Changsha, 410011, China

Location

The Affiliated Brain Hospital of Guangzhou Medical University

Guangzhou, 510370, China

Location

The third affiliated hospital of Sun Yat-Sen University

Guangzhou, 510630, China

Location

Huzhou Third Municipal Hospital

Huzhou, 313000, China

Location

Shandong Daizhuang Hospital

Jining, 272051, China

Location

The First Affilliated Hospital Of Kunming of Medical College

Kunming, 650032, China

Location

Nanjing Brain Hospital

Nanjing, 210029, China

Location

The Affilicated Kangning Hospital of Ningbo University

Ningbo, 315201, China

Location

Shanghai Mental Health Center

Shanghai, 200030, China

Location

Tongji Hospital, Tongji University

Shanghai, 200065, China

Location

Shenzhen Kangning Hospital

Shenzhen, 518003, China

Location

The First Hospital of Hebei Medical University

Shijiazhuang, 050030, China

Location

Tianjin Anding Hospital

Tianjin, 300222, China

Location

Wuxi mental health center

Wuxi, 214151, China

Location

First Affiliated Hospital of Xi'an JiaoTong University

Xi'an, 710061, China

Location

Xi'an Mental Health Center

Xi'an, 710101, China

Location

The Second Affiliated Hospital of Xinxiang Medical Univ.

Xinxiang, 453002, China

Location

Zhumadian Psychiatric Hospital

Zhumadian, 463000, China

Location

Centro de Investigación y Proyectos en neurociencia CIPNA

Barranquilla, 80020, Colombia

Location

E.S.E Hospital Mental de Antioquia

Bello, 51053, Colombia

Location

Instituto Colombiano del Sistema Nervioso- Clínica Montserrat

Bogotá, 110121, Colombia

Location

Centro de Investigaciones del Sistema Nervioso SAS- Grupo Cisne SAS

Bogotá, 111166, Colombia

Location

Psynapsis Salud Mental S.A.

Pereira, 660003, Colombia

Location

Clincal Hospital Centre Rijeka

Rijeka, 51 000, Croatia

Location

Clinical Hospital Centre Zagreb

Zagreb, 10 000, Croatia

Location

Solmed Polyclinic

Zagreb, 1000, Croatia

Location

Psychiatric Hospital 'Sveti Ivan'

Zagreb, 10090, Croatia

Location

University Psychiatric Hospital Vrapce

Zagreb, 10090, Croatia

Location

National Institute of Mental Health

Klecany, 25067, Czechia

Location

MP Meditrine s.r.o.

Ostrava, 70800, Czechia

Location

A-SHINE s.r.o

Pilsen, 30100, Czechia

Location

PRAGTIS s.r.o.

Prague, 120 00, Czechia

Location

INEP medical s.r.o.

Prague, 18600, Czechia

Location

Psychiatrie Ricany s.r.o.

Říčany, 251 01, Czechia

Location

Aalborg Universitetsshospital

Aalborg, 9000, Denmark

Location

Aarhus University Hospital

Aarhus N, 8200, Denmark

Location

Psykiatrisk Center Glostrup

Glostrup Municipality, 2600, Denmark

Location

Aurora hospital

Helsinki, 00250, Finland

Location

CRST - Clinical Research Services Turku

Turku, 20520, Finland

Location

HOP Charles Perrens

Bordeaux, 33076, France

Location

HOP la Colombière

Montpellier, 34295, France

Location

HOP Hôtel-Dieu

Nantes, 44093, France

Location

Hôpital Pasteur

Nice, 06000, France

Location

HOP Carémeau

Nîmes, 30029, France

Location

HOP Guillaume Régnier

Rennes, 35703, France

Location

HOP Rouffach

Rouffach, 68250, France

Location

HOP Nord-Saint-Priest-en-Jarez-53664

Saint-Priest-en-Jarez, 42270, France

Location

Zentrum für klinische Forschung Dr. med. I. Schöll GmbH

Bad Homburg, 61348, Germany

Location

Praxis Dr. Hahn, Berlin

Berlin, 13187, Germany

Location

Studienzentrum für Neurologie und Psychiatrie

Böblingen, 71034, Germany

Location

LWL-Klinik Dortmund

Dortmund, 44287, Germany

Location

Universitätsmedizin der Johannes Gutenberg-Universität Mainz

Mainz, 55131, Germany

Location

Zentralinstitut für seelische Gesundheit

Mannheim, 68159, Germany

Location

Klinikum der Universität München AÖR

München, 80336, Germany

Location

Universitätsklinikum Tübingen

Tübingen, 72076, Germany

Location

Studienzentrum Nord-West

Westerstede, 26655, Germany

Location

Eginition Hospital

Athens, 11528, Greece

Location

"Attikon" University General Hospital of Attica

Chaïdári, 12462, Greece

Location

Psychiatric Hospital of Attica

Haidari, 12462, Greece

Location

AX Mental Health Clinic

Heraklion, 71305, Greece

Location

General Oncology Hospital "Agioi Anargyri"

Nea Kifissia, 14564, Greece

Location

University General Hospital of Thessaloniki AHEPA

Thessaloniki, 54636, Greece

Location

General Hospital of Thessaloniki "G. Papanikolaou"

Thessaloniki, 57 010, Greece

Location

Semmelweis University

Budapest, 1082, Hungary

Location

ASST degli Spedali Civili di Brescia

Brescia, 25123, Italy

Location

A.O. Fatebenefratelli

Milan, 20121, Italy

Location

Ist. San Raffaele Turro

Milan, 20127, Italy

Location

Azienda Sanitaria Ospedale S. Luigi Gonzaga

Orbassano (TO), 10043, Italy

Location

A.O.U. Senese

Siena, 53100, Italy

Location

Hotei Hospital

Aichi, Konan, 483-8248, Japan

Location

Okehazama Hospital Fujita Kokoro Care Center

Aichi, Toyoake, 470-1168, Japan

Location

Toyota Memorial Hospital

Aichi, Toyota, 471-8513, Japan

Location

National Hospital Organization Shimofusa Psychiatric Medical Center

Chiba, Chiba, 266-0007, Japan

Location

Japan Institute for Health Security National Kohnodai Medical Center

Chiba, Ichikawa, 272-8516, Japan

Location

Uematsu Mental Clinic

Fukuoka, Chikugo, 833-0041, Japan

Location

Mental Clinic Sakurazaka

Fukuoka, Fukuoka, 810-0023, Japan

Location

AK Clinic

Fukuoka, Fukuoka, 810-0031, Japan

Location

Fukuoka University Hospital

Fukuoka, Fukuoka, 814-0180, Japan

Location

Kuramitsu Hospital

Fukuoka, Fukuoka, 819-0037, Japan

Location

Hirota Clinic

Fukuoka, Kurume, 830-0033, Japan

Location

Shiranui Hospital

Fukuoka, Omuta, 836-0004, Japan

Location

Kishi Hospital

Gumma, Kiryu, 376-0011, Japan

Location

Obihiro-Kosei General Hospital

Hokkaido, Obihiro, 080-0024, Japan

Location

Hokudai-dori Mental Health Clinic

Hokkaido, Sapporo, 001-0010, Japan

Location

Hokkaido University Hospital

Hokkaido, Sapporo, 060-8648, Japan

Location

Tatsuta Clinic

Hyogo, Kobe, 651-0097, Japan

Location

Kanazawa Medical University Hospital

Ishikwa, Kahoku-gun, 920-0293, Japan

Location

Kishiro Mental Clinic

Kanagawa, Kawasaki, 214-0014, Japan

Location

St. Marianna University Hospital

Kanagawa, Kawasaki, 216-8511, Japan

Location

Links Mental Clinic

Kanagawa, Yokohama, 224-0001, Japan

Location

Yokohama Onoecho Clinic

Kanagawa, Yokohama, 231-0015, Japan

Location

Hino Hospital

Kanagawa, Yokohama, 234-0051, Japan

Location

Yokohama City University Hospital

Kanagawa, Yokohama, 236-0004, Japan

Location

Kochi Health Sciences Center

Kochi, Kochi, 781-8555, Japan

Location

Yuge Neuropsychiatric Hospital

Kumamoto, Kumamoto, 861-8002, Japan

Location

Medical Corporation Yamadakai Yatsushiro Welfare Hospital

Kumamoto, Yatsushiro, 866-0043, Japan

Location

National Hospital Organization Maizuru Medical Center

Kyoto, Maizuru, 625-8502, Japan

Location

Tohoku University Hospital

Miyagi, Sendai, 980-8574, Japan

Location

Shounan Hospital

Nagano, Matsumoto, 390-0847, Japan

Location

Suwa Red Cross Hospital

Nagano, Suwa, 392-8510, Japan

Location

Nara Medical University Hospital

Nara, Kashihara, 634-8522, Japan

Location

Niigata University Medical and Dental Hospital

Niigata, Niigata, 951-8520, Japan

Location

University of the Ryukyus Hospital

Okinawa, Ginowan, 901-2725, Japan

Location

Osaka City Hospital Organization Osaka City General Hospital

Osaka, Osaka, 534-0021, Japan

Location

National Hospital Organization Hizen Psychiatric Medical Center

Saga, Kanzaki-gun, 842-0192, Japan

Location

Rainbow and Sea Hospital

Saga, Karatsu, 847-0031, Japan

Location

Inuo Hospital

Saga, Tosu, 841-0081, Japan

Location

Nishi Kumagaya Hospital

Saitama, Kumagaya, 360-0816, Japan

Location

Sho Midori Hospital

Saitama, Saitama, 336-0022, Japan

Location

Dokkyo Medical University Hospital

Tochigi, Shimotsuga-gun, 321-0293, Japan

Location

Tokushima University Hospital

Tokushima, Tokushima, 770-8503, Japan

Location

Medical Corporation Seijin Hospital

Tokyo, Adachi-ku, 121-8515, Japan

Location

Institute of Science Tokyo Hospital

Tokyo, Bunkyo-ku, 113-8519, Japan

Location

Nishigahara Hospital

Tokyo, Kita-ku, 114-0024, Japan

Location

National Center of Neurology and Psychiatry

Tokyo, Kodaira, 187-8851, Japan

Location

Asuka Hospital

Tokyo, Machida, 194-0005, Japan

Location

Minami-Aoyama Antique Street Clinic

Tokyo, Minato-ku, 107-0062, Japan

Location

Toho University Omori Medical Center

Tokyo, Ota-ku, 143-8541, Japan

Location

Maynds Tower Mental Clinic

Tokyo, Shibuya-ku, 151-0053, Japan

Location

Shinjuku East Mental Clinic

Tokyo, Shinjuku-ku, 160-0021, Japan

Location

Ohwa Mental Clinic

Tokyo, Toshima-ku, 170-0002, Japan

Location

Hokuriku Hospital

Toyama, Nanto, 939-1893, Japan

Location

Yamaguchi University Hospital

Yamaguchi, Ube, 755-8505, Japan

Location

University of Yamanashi Hospital

Yamanashi, Chuo, 409-3898, Japan

Location

JSC Romuvos Clinic

Kaunas, LT-44279, Lithuania

Location

LUHS KH Psichiatric Clinic Mariu Division

Kaunas, LT-53137, Lithuania

Location

JSC Medical center "Puriena"

Šilutė, LT-99142, Lithuania

Location

Vilnius City Mental Health Center

Vilnius, LT-10309, Lithuania

Location

Hospital Raja Permaisuri Bainun

Ipoh, Perak, 30450, Malaysia

Location

University Malaya Medical Centre

Kuala Lumpur, 59100, Malaysia

Location

Hospital Sentosa

Kuching, 93250, Malaysia

Location

Hospital Tuanku Ja'afar

Seremban, 70300, Malaysia

Location

Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada S.C.

Culiacán, 80230, Mexico

Location

Clinica Cemelli

Guadalajara, 44660, Mexico

Location

Hospital Aranda de la Parra

León, 37000, Mexico

Location

Centro de Investigación Clinica Acelerada, S.C.

Mexico City, 07369, Mexico

Location

GabiPros S.C.

Mexico City, 07810, Mexico

Location

Instituto Nacional de Neurologia y Neurocirugia

Mexico City, 14269, Mexico

Location

Medical Care & Research SA de CV

Mérida, 97070, Mexico

Location

Iecsi S.C.

Monterrey, 64310, Mexico

Location

CIT-Neuropsique S.C

Monterrey, 64610, Mexico

Location

Instituto de Informacion e Investigacion en Salud Mental A.C. (INFOSAME).

Monterrey, 64710, Mexico

Location

Hospital Universitario Dr Jose Eleuterio Gonzalez

Nuevo León, 64460, Mexico

Location

BIND Investigaciones S.C.

San Luis Potosí City, 78213, Mexico

Location

Universitair Medisch Centrum Groningen

Groningen, 9713 AV, Netherlands

Location

North Shore Hospital

Takpuna Auckland, 0622, New Zealand

Location

Sykehuset Østfold HF, avd. Moss

Moss, N-1535, Norway

Location

Akershus universitetssykehus Oslo

Oslo, 0963, Norway

Location

Philippine General Hospital

Manila, Philippines, 1000, Philippines

Location

Psychiatric Doctor's Office Ireneusz Kaczorowski

Bełchatów, 97-400, Poland

Location

Podlassian Center of Psychogeriatry, Bialystok

Bialystok, 15-756, Poland

Location

Health Center Alcea

Gdansk, 80-283, Poland

Location

MentalMEDIC

Gliwice, 44100, Poland

Location

Central Clinical Hospital of the Medical University of Lodz

Lodz, 92-216, Poland

Location

Individual Specialist Medical Practice Filip Rybakowski

Poznan, 60-744, Poland

Location

EUROMEDIS Sp. z o.o., Szczecin

Szczecin, 70-111, Poland

Location

Institute of Psychiatry and Neurology in Warsaw

Warsaw, 02-957, Poland

Location

Clinhouse

Zabrze, 41-807, Poland

Location

ULS da Região de Leiria, E.P.E.

Leiria, 2410-197, Portugal

Location

Mental Health Center Sector 4

Bucharest, 040872, Romania

Location

SC Carpe Diem SRL

Sibiu, 557260, Romania

Location

Clinical Hospital Center Dr. Dragisa Misovic

Belgrade, 11000, Serbia

Location

General Hospital Euromedik

Belgrade, 11000, Serbia

Location

Institute for Mental Health

Belgrade, 11000, Serbia

Location

Special Hospital for Psychiatric Diseases Gornja Toponica

Gornja Toponica, 18202, Serbia

Location

Special Hospital for Psychiatric Diseases Sveti Vračevi

Novi Kneževac, 23330, Serbia

Location

Clinical Center of Vojvodina

Novi Sad, 21000, Serbia

Location

Psychiatria, Nemocnica s poliklinikou Prievidza so sidlom v Bojniciach

Bojnice, 97201, Slovakia

Location

EPAMED s.r.o.

Košice, 040 01, Slovakia

Location

Psychiatricka Ambulancia Psycholine s.r.o.

Rimavská Sobota, 97901, Slovakia

Location

Inje University Busan Paik Hospital

Busan, 47392, South Korea

Location

Yeungnam University Medical Center

Daegu, 42415, South Korea

Location

Daegu Catholic University Medical Center

Daegu, 42472, South Korea

Location

Chonnam National University Hospital

Gwangju, 61453, South Korea

Location

Inha University Hospital

Incheon, 22332, South Korea

Location

Seoul National University Bundang Hospital

Seongnam, 13620, South Korea

Location

Seoul National University Hospital

Seoul, 03080, South Korea

Location

Pusan National University Yangsan Hospital

Yangsan, 626-770, South Korea

Location

Hestia Palau

Barcelona, 08025, Spain

Location

Hospital Clínic de Barcelona

Barcelona, 08036, Spain

Location

Hospital Universitario General de Villalba

Collado de Villalba, 28400, Spain

Location

Hospital Universitario Reina Sofía

Córdoba, 14004, Spain

Location

Hospital Puerta de Hierro

Majadahonda, 28222, Spain

Location

Centro de Salud de San Juan

Salamanca, 37005, Spain

Location

Hospital Virgen del Rocío

Seville, 41013, Spain

Location

Hospital Clinico Universitario de Valencia

Valencia, 46010, Spain

Location

Hospital Nicolás Peña

Vigo, 36211, Spain

Location

Hospital Provincial. Complejo Asistencial de Zamora

Zamora, 49021, Spain

Location

Psykiatriska Kliniken

Helsingborg, 20153, Sweden

Location

Akademiska sjukhuset

Uppsala, 751 85, Sweden

Location

Kai-Syuan Psychiatric Hospital

Kaohsiung City, 802, Taiwan

Location

Chang Gung Memorial Hospital-Keelung

Keelung, 204, Taiwan

Location

Chung Shan Medical University Hospital

Taichung, 40201, Taiwan

Location

NCKUH

Tainan, 704, Taiwan

Location

National Taiwan University Hospital

Taipei, 100, Taiwan

Location

Taipei Veterans General Hospital

Taipei, 11217, Taiwan

Location

Taoyuan Psychiatric Center

Taoyuan District, 33058, Taiwan

Location

Chang Gung Memorial Hospital, Linkou

Taoyuan District, 330, Taiwan

Location

Hacettepe Universitesi Tip Fakultesi

Ankara, 06230, Turkey (Türkiye)

Location

Ankara University Medical School

Ankara, 06590, Turkey (Türkiye)

Location

Istanbul University

Istanbul, 34093, Turkey (Türkiye)

Location

Dokuz Eylul Universitesi Psikiyatri A.B.D.

Izmir, 35340, Turkey (Türkiye)

Location

Celal Bayar Universitesi Tip Fakultesi

Manisa, 45030, Turkey (Türkiye)

Location

Communal Non-Profit Enterprise "Regional Clinical Psychiatric Hospital" of Kirovohrad Regional Council

Nove, 25491, Ukraine

Location

Bodmin Community Hospital

Bodmin, PL31 2QT, United Kingdom

Location

The Fritchie Centre

Cheltenham, GL53 9DZ, United Kingdom

Location

Redesmere

Chester, CH2 1BQ, United Kingdom

Location

Western General Hospital

Edinburgh, EH4 2XU, United Kingdom

Location

Queen Elizabeth University Hospital

Glasgow, G51 4TF, United Kingdom

Location

Maudsley Hospital

London, SE5 8AZ, United Kingdom

Location

Warneford Hospital

Oxford, OX3 7JX, United Kingdom

Location

Moorgreen Hospital

Southampton, SO30 3JB, United Kingdom

Location

Related Links

MeSH Terms

Conditions

Schizophrenia

Interventions

BI 425809

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic DisordersMental Disorders

Limitations and Caveats

As per protocol, end of treatment was planned for Week 52. Forty-nine patients stayed longer on treatment (protocol deviation), up to a maximum of 60.1 weeks.

Results Point of Contact

Title
Boehringer Ingelheim, Call Center
Organization
Boehringer Ingelheim

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 14, 2022

First Posted

January 27, 2022

Study Start

March 21, 2022

Primary Completion

February 26, 2025

Study Completion

March 18, 2025

Last Updated

April 8, 2026

Results First Posted

April 8, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will share

Once the criteria in section "Time Frame" are fulfilled, researchers can use the following link https://www.clinicalstudies.boehringer-ingelheim.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement". Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.

Shared Documents
STUDY PROTOCOL, SAP, CSR
Time Frame
After structured results have been posted, all regulatory activities are completed in the US and EU for the product and indication, and after the primary manuscript has been accepted for publication.
Access Criteria
For study documents - upon signing of a 'Document Sharing Agreement'. For study data - 1. after the submission and approval of the research proposal (checks will be performed by the sponsor and/or the independent review panel, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a legal agreement.
More information

Locations