Trials Sponsors Conditions Drugs Pricing

Conditions

Gut Microbiota Metabolomics Stomach Neoplasms

Outcome Measures

Primary Outcomes (5)

Participants' characteristics
To obtain participants' characteristics, including age, gender, alcohol consumption, body mass index, smoking, medications.
1 day
Microbial community structure
To assess participants' microbiome composition in faecal samples, inclding microbial diversity and richness.
1 day
Metabolite composition
To measure the metabolite profiles in participants' faecal samples and serum samples, involving Bile acids, short chain fatty acids, TMAO and related metabolites, amino acids, fatty acids, organic acids, flavonoids, plant hormones, neurotransmitters.
1 day
Microbes-metabolites correlations
To assess the correlations of gut microbiota and metabolites by Spearman's correlation analysis.
1 day
Response of target organ
To find the effects of microflora and metabolites on target organ by transcriptome sequencing.
1 day

Study Arms (3)

Healthy group

Healthy people in the community.

Procedure: Healthy control specimen collection

Non-Borrmann IV group

Patients with Borrmann types I, II and III gastric cancer.

Procedure: Non-Borrmann IV patient specimen collection

Borrmann IV group

Patients with Borrmann type IV gastric cancer.

Procedure: Borrmann IV patient specimen collection

Interventions

Healthy control specimen collectionProcedure

Collecting blood and feces from healthy population.

Healthy group

Non-Borrmann IV patient specimen collectionProcedure

Collecting blood, feces and gastric cancer tissues from Non-Borrmann IV patients.

Non-Borrmann IV group

Eligibility Criteria

Age18 Years - 70 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Healthy population will be selected from community samples. Non-Borrmann IV and Borrmann IV patients will be selected from Department of Oncology in hospitals.

You may qualify if:

Patients who sign informed consent.

Sponsors & Collaborators

The General Hospital of Fushun Mining Bureau
Type not reportedcollaborator
The fourth People's Hospital of Changzhou
Type not reportedcollaborator

Study Sites (6)

The fourth People's Hospital of Changzhou

Changzhou, Jiangsu, 213001, China

RECRUITING

Yan LiCONTACT

Chaoyang Central Hospital

Chaoyang, Liaoning, 122099, China

RECRUITING

Shigang GuoCONTACT

The General Hospital of Fushun Mining Bureau

Fushun, Liaoning, 113012, China

ENROLLING_BY_INVITATION

MeSH Terms

Conditions

Stomach Neoplasms

Condition Hierarchy (Ancestors)

Gastrointestinal NeoplasmsDigestive System NeoplasmsNeoplasms by SiteNeoplasmsDigestive System DiseasesGastrointestinal DiseasesStomach Diseases

Study Officials

Kai Li, MD
First Hospital of China Medical University
PRINCIPAL INVESTIGATOR

Central Study Contacts

Kai Li, MD

CONTACT

8613998245233 cmu1h_likai@163.com

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: PROSPECTIVE
Target Duration: 5 Years
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Deputy Director of surgical Oncology

Study Record Dates

First Submitted

January 11, 2022

First Posted

January 25, 2022

Study Start

February 28, 2022

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Primary Completion

Gut Microbiota and Metabonomics

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (5)

Study Arms (3)

Healthy group

Non-Borrmann IV group

Borrmann IV group

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (6)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (5)

Study Arms (3)

Healthy group

Non-Borrmann IV group

Borrmann IV group

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (6)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations