NCT05202938

Brief Summary

A flexible energy metabolism matched with the contractile needs of the muscle is essential to a normal heart. Loss of metabolic flexibility and cardiac systolic efficiency coexist in Sepsis-induced Myocardial Dysfunction (SIMD), a phenomenon attributed to mitochondrial dysfunction and mishandling of energy substrates. Cardiac positron emission tomography (PET) could allow to quantify non invasively the selection of energy substrates by the hearts in sepsis and will be associated in parallel with functional status (ultrasound cardiography), injury biomarkers, apelinergic and metabolomic blood profiles. Comparisons will be performed between septic and acute on chronic heart failures, with or without systolic dysfunction.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
32

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jul 2022

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 10, 2022

Completed
14 days until next milestone

First Posted

Study publicly available on registry

January 24, 2022

Completed
6 months until next milestone

Study Start

First participant enrolled

July 21, 2022

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 21, 2023

Completed
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 21, 2024

Completed
Last Updated

July 20, 2023

Status Verified

July 1, 2023

Enrollment Period

1.4 years

First QC Date

January 10, 2022

Last Update Submit

July 18, 2023

Conditions

Septic ShockChronic Heart Failure

Keywords

Septic shockHeart dysfunctionPositron emission tomographyEnergy substrates (glucose, fatty acid, acetate)Mitochondrial activity

Outcome Measures

Primary Outcomes (4)

  • FDG PET scan

    Positron emission tomography with FDG radiotracer. It will report the glucose uptake by the heart.

    25 minutes

  • Palmitate PET scan

    Positron emission tomography with C11-palmitate radiotracer. It will report the fatty acid uptake by the heart.

    15 minutes

  • Acetate PET scan

    Positron emission tomography with C11-acetate radiotracer. It will report the acetate uptake by the heart.

    10 minutes

  • Quantitative study of blood FDG:palmitate balance.

    Measure of the blood FDG:palmitate balance by spectroscopy LC-MS and NMR.

    20 minutes

Secondary Outcomes (3)

  • Measure of myocardial injury biomarkers.

    45 minutes

  • Measure of apelinergics.

    45 minutes

  • Profiling of the systemic metabolomic.

    45 minutes

Study Arms (4)

Septic shock with SIMD: SIMD+

8 patients in septic shock (Sepsis-3-) with SIMD: ejection fraction (LVEF) \< 45% in the first 48 hours of admission into the intensive care unit. No prior cardiac ultrasound or normal cardiac ultrasound values less than 2 years ago , or an ino-vasotropic infusion (milrinone, dobutamine, norepinephrine or epinephrine) required to obtain a LVEF ≥ 45%, or a drop of ≥ 20% compared to the LVEF value record ed less than 2 years ago.

Diagnostic Test: ultrasound cardiographyDiagnostic Test: FDG PET scanDiagnostic Test: Palmitate PET scanDiagnostic Test: Acetate PET scanDiagnostic Test: Blood sampling

Septic shock without SIMD: SIMD-

8 patients in septic shock (Sepsis-3) without SIMD. Ejection fraction (LVEF) ≥ 45% with or without ino-vasotropic infusion (milrinone, dobutamine, norepinephrine or epinephrine), or similar to the LVEF recorded less than 2 years ago.

Diagnostic Test: ultrasound cardiographyDiagnostic Test: FDG PET scanDiagnostic Test: Palmitate PET scanDiagnostic Test: Acetate PET scanDiagnostic Test: Blood sampling

Acute Heart Failure with reduced Ejection Fraction: HFrEF

8 patients with acutely reduced ejection fraction (LVEF) \< 50%. with or without ino-vasotropic infusion (milrinone, dobutamine, norepinephrine or epinephrine) No prior cardiac ultrasound, or normal cardiac ultrasound values less than 2 years ago, or a drop of ≥ 20% compared to the LVEF recorded less than 2 years ago. No evidence of sepsis or septic shock.

Diagnostic Test: ultrasound cardiographyDiagnostic Test: FDG PET scanDiagnostic Test: Palmitate PET scanDiagnostic Test: Acetate PET scanDiagnostic Test: Blood sampling

Acute Heart Failure with preserved Ejection Fraction: HFpEF

8 patients with acute heart failure and a preserved ejection fraction (ejection fraction (LVEF ≥ 50% or similar to normal cardiac ultrasound values recorded less than 2 years ago). No evidence of septic shock.

Diagnostic Test: ultrasound cardiographyDiagnostic Test: FDG PET scanDiagnostic Test: Palmitate PET scanDiagnostic Test: Acetate PET scanDiagnostic Test: Blood sampling

Interventions

ultrasound cardiographyDIAGNOSTIC_TEST

Ultrasound to check heart functions and systolic ejection fraction.

Acute Heart Failure with preserved Ejection Fraction: HFpEFAcute Heart Failure with reduced Ejection Fraction: HFrEFSeptic shock with SIMD: SIMD+Septic shock without SIMD: SIMD-
FDG PET scanDIAGNOSTIC_TEST

FDG venous injection and positron emission tomography scan.

Also known as: FDG positron emission tomography
Acute Heart Failure with preserved Ejection Fraction: HFpEFAcute Heart Failure with reduced Ejection Fraction: HFrEFSeptic shock with SIMD: SIMD+Septic shock without SIMD: SIMD-
Palmitate PET scanDIAGNOSTIC_TEST

C11-Palmitate venous injection and positron emission tomography scan.

Also known as: Palmitate positron emission tomography
Acute Heart Failure with preserved Ejection Fraction: HFpEFAcute Heart Failure with reduced Ejection Fraction: HFrEFSeptic shock with SIMD: SIMD+Septic shock without SIMD: SIMD-
Acetate PET scanDIAGNOSTIC_TEST

C11-Acetate venous injection and positron emission tomography scan.

Also known as: Acetate positron emission tomography
Acute Heart Failure with preserved Ejection Fraction: HFpEFAcute Heart Failure with reduced Ejection Fraction: HFrEFSeptic shock with SIMD: SIMD+Septic shock without SIMD: SIMD-
Blood samplingDIAGNOSTIC_TEST

Collecting 20ml of venous blood.

Also known as: Collecting blood sample
Acute Heart Failure with preserved Ejection Fraction: HFpEFAcute Heart Failure with reduced Ejection Fraction: HFrEFSeptic shock with SIMD: SIMD+Septic shock without SIMD: SIMD-

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients hospitalized in intensive care unit and coronary unit of the Sherbrooke hospital/CHUS.

You may qualify if:

  • Patients hospitalized in intensive care unit and coronary unit of the Sherbrooke hospital/CHUS.

You may not qualify if:

  • Pediatric patients
  • Albumin allergy
  • Moribund patients
  • Patients too much unstable for the imaging procedure (clinical judgment)
  • Unavailable tracers, staff, PET scan in a maximum delay of 72 hours

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHUS

Sherbrooke, Quebec, J1H5N4, Canada

RECRUITING

Related Publications (58)

  • Parrillo JE, Parker MM, Natanson C, Suffredini AF, Danner RL, Cunnion RE, Ognibene FP. Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann Intern Med. 1990 Aug 1;113(3):227-42. doi: 10.7326/0003-4819-113-3-227.

    PMID: 2197912BACKGROUND

  • Merx MW, Weber C. Sepsis and the heart. Circulation. 2007 Aug 14;116(7):793-802. doi: 10.1161/CIRCULATIONAHA.106.678359.

    PMID: 17698745BACKGROUND

  • Walley KR. Sepsis-induced myocardial dysfunction. Curr Opin Crit Care. 2018 Aug;24(4):292-299. doi: 10.1097/MCC.0000000000000507.

    PMID: 29846206BACKGROUND

  • Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, Des Rosiers C, Gerszten R, Glatz JF, Griffin JL, Gropler RJ, Holzhuetter HG, Kizer JR, Lewandowski ED, Malloy CR, Neubauer S, Peterson LR, Portman MA, Recchia FA, Van Eyk JE, Wang TJ; American Heart Association Council on Basic Cardiovascular Sciences. Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association. Circ Res. 2016 May 13;118(10):1659-701. doi: 10.1161/RES.0000000000000097. Epub 2016 Mar 24.

    PMID: 27012580BACKGROUND

  • Neely JR, Rovetto MJ, Oram JF. Myocardial utilization of carbohydrate and lipids. Prog Cardiovasc Dis. 1972 Nov-Dec;15(3):289-329. doi: 10.1016/0033-0620(72)90029-1. No abstract available.

    PMID: 4564017BACKGROUND

  • Krishnagopalan S, Kumar A, Parrillo JE, Kumar A. Myocardial dysfunction in the patient with sepsis. Curr Opin Crit Care. 2002 Oct;8(5):376-88. doi: 10.1097/00075198-200210000-00003.

    PMID: 12357104BACKGROUND

  • Antonucci E, Fiaccadori E, Donadello K, Taccone FS, Franchi F, Scolletta S. Myocardial depression in sepsis: from pathogenesis to clinical manifestations and treatment. J Crit Care. 2014 Aug;29(4):500-11. doi: 10.1016/j.jcrc.2014.03.028. Epub 2014 Apr 5.

    PMID: 24794044BACKGROUND

  • Rudiger A, Singer M. Mechanisms of sepsis-induced cardiac dysfunction. Crit Care Med. 2007 Jun;35(6):1599-608. doi: 10.1097/01.CCM.0000266683.64081.02.

    PMID: 17452940BACKGROUND

  • Lopaschuk GD. Metabolic Modulators in Heart Disease: Past, Present, and Future. Can J Cardiol. 2017 Jul;33(7):838-849. doi: 10.1016/j.cjca.2016.12.013. Epub 2016 Dec 21.

    PMID: 28279520BACKGROUND

  • Karwi QG, Uddin GM, Ho KL, Lopaschuk GD. Loss of Metabolic Flexibility in the Failing Heart. Front Cardiovasc Med. 2018 Jun 6;5:68. doi: 10.3389/fcvm.2018.00068. eCollection 2018.

    PMID: 29928647BACKGROUND

  • Pascual F, Coleman RA. Fuel availability and fate in cardiac metabolism: A tale of two substrates. Biochim Biophys Acta. 2016 Oct;1861(10):1425-33. doi: 10.1016/j.bbalip.2016.03.014. Epub 2016 Mar 16.

    PMID: 26993579BACKGROUND

  • Doenst T, Nguyen TD, Abel ED. Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res. 2013 Aug 30;113(6):709-24. doi: 10.1161/CIRCRESAHA.113.300376.

    PMID: 23989714BACKGROUND

  • Drosatos K, Lymperopoulos A, Kennel PJ, Pollak N, Schulze PC, Goldberg IJ. Pathophysiology of sepsis-related cardiac dysfunction: driven by inflammation, energy mismanagement, or both? Curr Heart Fail Rep. 2015 Apr;12(2):130-40. doi: 10.1007/s11897-014-0247-z.

    PMID: 25475180BACKGROUND

  • Carre JE, Singer M. Cellular energetic metabolism in sepsis: the need for a systems approach. Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):763-71. doi: 10.1016/j.bbabio.2008.04.024. Epub 2008 Apr 23.

    PMID: 18482575BACKGROUND

  • Mangmool S, Denkaew T, Parichatikanond W, Kurose H. beta-Adrenergic Receptor and Insulin Resistance in the Heart. Biomol Ther (Seoul). 2017 Jan 1;25(1):44-56. doi: 10.4062/biomolther.2016.128.

    PMID: 28035081BACKGROUND

  • Ehrman RR, Sullivan AN, Favot MJ, Sherwin RL, Reynolds CA, Abidov A, Levy PD. Pathophysiology, echocardiographic evaluation, biomarker findings, and prognostic implications of septic cardiomyopathy: a review of the literature. Crit Care. 2018 May 4;22(1):112. doi: 10.1186/s13054-018-2043-8.

    PMID: 29724231BACKGROUND

  • Bertrand C, Valet P, Castan-Laurell I. Apelin and energy metabolism. Front Physiol. 2015 Apr 10;6:115. doi: 10.3389/fphys.2015.00115. eCollection 2015.

    PMID: 25914650BACKGROUND

  • Reddy YN, Borlaug BA. Heart Failure With Preserved Ejection Fraction. Curr Probl Cardiol. 2016 Apr;41(4):145-88. doi: 10.1016/j.cpcardiol.2015.12.002. Epub 2015 Dec 9.

    PMID: 26952248BACKGROUND

  • Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, Angus DC, Reinhart K; International Forum of Acute Care Trialists. Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations. Am J Respir Crit Care Med. 2016 Feb 1;193(3):259-72. doi: 10.1164/rccm.201504-0781OC.

    PMID: 26414292RESULT

  • Parker MM, Shelhamer JH, Bacharach SL, Green MV, Natanson C, Frederick TM, Damske BA, Parrillo JE. Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med. 1984 Apr;100(4):483-90. doi: 10.7326/0003-4819-100-4-483.

    PMID: 6703540RESULT

  • Trager K, Radermacher P. Catecholamines in the treatment of septic shock: effects beyond perfusion. Crit Care Resusc. 2003 Dec;5(4):270-6.

    PMID: 16563117RESULT

  • Hartmann C, Radermacher P, Wepler M, Nussbaum B. Non-Hemodynamic Effects of Catecholamines. Shock. 2017 Oct;48(4):390-400. doi: 10.1097/SHK.0000000000000879.

    PMID: 28915214RESULT

  • Hou T, Zhang R, Jian C, Ding W, Wang Y, Ling S, Ma Q, Hu X, Cheng H, Wang X. NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly. Cell Res. 2019 Sep;29(9):754-766. doi: 10.1038/s41422-019-0208-x. Epub 2019 Jul 31.

    PMID: 31366990RESULT

  • Banks L, Wells GD, McCrindle BW. Cardiac energy metabolism is positively associated with skeletal muscle energy metabolism in physically active adolescents and young adults. Appl Physiol Nutr Metab. 2014 Mar;39(3):363-8. doi: 10.1139/apnm-2013-0312. Epub 2013 Oct 9.

    PMID: 24552379RESULT

  • Gertz EW, Wisneski JA, Stanley WC, Neese RA. Myocardial substrate utilization during exercise in humans. Dual carbon-labeled carbohydrate isotope experiments. J Clin Invest. 1988 Dec;82(6):2017-25. doi: 10.1172/JCI113822.

    PMID: 3198763RESULT

  • Vieillard-Baron A, Caille V, Charron C, Belliard G, Page B, Jardin F. Actual incidence of global left ventricular hypokinesia in adult septic shock. Crit Care Med. 2008 Jun;36(6):1701-6. doi: 10.1097/CCM.0b013e318174db05.

    PMID: 18496368RESULT

  • Bouhemad B, Nicolas-Robin A, Arbelot C, Arthaud M, Feger F, Rouby JJ. Isolated and reversible impairment of ventricular relaxation in patients with septic shock. Crit Care Med. 2008 Mar;36(3):766-74. doi: 10.1097/CCM.0B013E31816596BC.

    PMID: 18431265RESULT

  • Bouhemad B, Nicolas-Robin A, Arbelot C, Arthaud M, Feger F, Rouby JJ. Acute left ventricular dilatation and shock-induced myocardial dysfunction. Crit Care Med. 2009 Feb;37(2):441-7. doi: 10.1097/CCM.0b013e318194ac44.

    PMID: 19114917RESULT

  • Kumar A, Bunnell E, Lynn M, Anel R, Habet K, Neumann A, Parrillo JE. Experimental human endotoxemia is associated with depression of load-independent contractility indices: prevention by the lipid a analogue E5531. Chest. 2004 Sep;126(3):860-7. doi: 10.1378/chest.126.3.860.

    PMID: 15364767RESULT

  • Vincent JL, Gris P, Coffernils M, Leon M, Pinsky M, Reuse C, Kahn RJ. Myocardial depression characterizes the fatal course of septic shock. Surgery. 1992 Jun;111(6):660-7.

    PMID: 1595062RESULT

  • Turner A, Tsamitros M, Bellomo R. Myocardial cell injury in septic shock. Crit Care Med. 1999 Sep;27(9):1775-80. doi: 10.1097/00003246-199909000-00012.

    PMID: 10507597RESULT

  • Chagnon F, Metz CN, Bucala R, Lesur O. Endotoxin-induced myocardial dysfunction: effects of macrophage migration inhibitory factor neutralization. Circ Res. 2005 May 27;96(10):1095-102. doi: 10.1161/01.RES.0000168327.22888.4d. Epub 2005 May 5.

    PMID: 15879312RESULT

  • Parrillo JE, Burch C, Shelhamer JH, Parker MM, Natanson C, Schuette W. A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance. J Clin Invest. 1985 Oct;76(4):1539-53. doi: 10.1172/JCI112135.

    PMID: 4056039RESULT

  • Duncan DJ, Yang Z, Hopkins PM, Steele DS, Harrison SM. TNF-alpha and IL-1beta increase Ca2+ leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes. Cell Calcium. 2010 Apr;47(4):378-86. doi: 10.1016/j.ceca.2010.02.002. Epub 2010 Mar 12.

    PMID: 20227109RESULT

  • Wu AH. Increased troponin in patients with sepsis and septic shock: myocardial necrosis or reversible myocardial depression? Intensive Care Med. 2001 Jun;27(6):959-61. doi: 10.1007/s001340100970. No abstract available.

    PMID: 11497152RESULT

  • Tavernier B, Li JM, El-Omar MM, Lanone S, Yang ZK, Trayer IP, Mebazaa A, Shah AM. Cardiac contractile impairment associated with increased phosphorylation of troponin I in endotoxemic rats. FASEB J. 2001 Feb;15(2):294-6. doi: 10.1096/fj.00-0433fje. Epub 2000 Dec 8.

    PMID: 11156941RESULT

  • Kakihana Y, Ito T, Nakahara M, Yamaguchi K, Yasuda T. Sepsis-induced myocardial dysfunction: pathophysiology and management. J Intensive Care. 2016 Mar 23;4:22. doi: 10.1186/s40560-016-0148-1. eCollection 2016.

    PMID: 27011791RESULT

  • Murashige D, Jang C, Neinast M, Edwards JJ, Cowan A, Hyman MC, Rabinowitz JD, Frankel DS, Arany Z. Comprehensive quantification of fuel use by the failing and nonfailing human heart. Science. 2020 Oct 16;370(6514):364-368. doi: 10.1126/science.abc8861.

    PMID: 33060364RESULT

  • Dhainaut JF, Huyghebaert MF, Monsallier JF, Lefevre G, Dall'Ava-Santucci J, Brunet F, Villemant D, Carli A, Raichvarg D. Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock. Circulation. 1987 Mar;75(3):533-41. doi: 10.1161/01.cir.75.3.533.

    PMID: 3815765RESULT

  • Tessier JP, Thurner B, Jungling E, Luckhoff A, Fischer Y. Impairment of glucose metabolism in hearts from rats treated with endotoxin. Cardiovasc Res. 2003 Oct 15;60(1):119-30. doi: 10.1016/s0008-6363(03)00320-1.

    PMID: 14522413RESULT

  • Kreymann G, Grosser S, Buggisch P, Gottschall C, Matthaei S, Greten H. Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock. Crit Care Med. 1993 Jul;21(7):1012-9. doi: 10.1097/00003246-199307000-00015.

    PMID: 8319458RESULT

  • Panitchote A, Thiangpak N, Hongsprabhas P, Hurst C. Energy expenditure in severe sepsis or septic shock in a Thai Medical Intensive Care Unit. Asia Pac J Clin Nutr. 2017;26(5):794-797. doi: 10.6133/apjcn.072016.10.

    PMID: 28802287RESULT

  • Chagnon F, Bentourkia M, Lecomte R, Lessard M, Lesur O. Endotoxin-induced heart dysfunction in rats: assessment of myocardial perfusion and permeability and the role of fluid resuscitation. Crit Care Med. 2006 Jan;34(1):127-33. doi: 10.1097/01.ccm.0000190622.02222.df.

    PMID: 16374166RESULT

  • Levy RJ, Piel DA, Acton PD, Zhou R, Ferrari VA, Karp JS, Deutschman CS. Evidence of myocardial hibernation in the septic heart. Crit Care Med. 2005 Dec;33(12):2752-6. doi: 10.1097/01.ccm.0000189943.60945.77.

    PMID: 16352955RESULT

  • Szokodi I, Tavi P, Foldes G, Voutilainen-Myllyla S, Ilves M, Tokola H, Pikkarainen S, Piuhola J, Rysa J, Toth M, Ruskoaho H. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ Res. 2002 Sep 6;91(5):434-40. doi: 10.1161/01.res.0000033522.37861.69.

    PMID: 12215493RESULT

  • Berry MF, Pirolli TJ, Jayasankar V, Burdick J, Morine KJ, Gardner TJ, Woo YJ. Apelin has in vivo inotropic effects on normal and failing hearts. Circulation. 2004 Sep 14;110(11 Suppl 1):II187-93. doi: 10.1161/01.CIR.0000138382.57325.5c.

    PMID: 15364861RESULT

  • Farkasfalvi K, Stagg MA, Coppen SR, Siedlecka U, Lee J, Soppa GK, Marczin N, Szokodi I, Yacoub MH, Terracciano CM. Direct effects of apelin on cardiomyocyte contractility and electrophysiology. Biochem Biophys Res Commun. 2007 Jun 15;357(4):889-95. doi: 10.1016/j.bbrc.2007.04.017. Epub 2007 Apr 12.

    PMID: 17466269RESULT

  • Chamberland C, Barajas-Martinez H, Haufe V, Fecteau MH, Delabre JF, Burashnikov A, Antzelevitch C, Lesur O, Chraibi A, Sarret P, Dumaine R. Modulation of canine cardiac sodium current by Apelin. J Mol Cell Cardiol. 2010 Apr;48(4):694-701. doi: 10.1016/j.yjmcc.2009.12.011. Epub 2009 Dec 28.

    PMID: 20036246RESULT

  • Li Z, He Q, Wu C, Chen L, Bi F, Zhou Y, Shan H. Apelin shorten QT interval by inhibiting Kir2.1/IK1 via a PI3K way in acute myocardial infarction. Biochem Biophys Res Commun. 2019 Sep 17;517(2):272-277. doi: 10.1016/j.bbrc.2019.07.041. Epub 2019 Jul 23.

    PMID: 31349969RESULT

  • Alfarano C, Foussal C, Lairez O, Calise D, Attane C, Anesia R, Daviaud D, Wanecq E, Parini A, Valet P, Kunduzova O. Transition from metabolic adaptation to maladaptation of the heart in obesity: role of apelin. Int J Obes (Lond). 2015 Feb;39(2):312-20. doi: 10.1038/ijo.2014.122. Epub 2014 Jul 16.

    PMID: 25027224RESULT

  • Mehrotra D, Wu J, Papangeli I, Chun HJ. Endothelium as a gatekeeper of fatty acid transport. Trends Endocrinol Metab. 2014 Feb;25(2):99-106. doi: 10.1016/j.tem.2013.11.001. Epub 2013 Dec 3.

    PMID: 24315207RESULT

  • Feng J, Zhao H, Du M, Wu X. The effect of apelin-13 on pancreatic islet beta cell mass and myocardial fatty acid and glucose metabolism of experimental type 2 diabetic rats. Peptides. 2019 Apr;114:1-7. doi: 10.1016/j.peptides.2019.03.006. Epub 2019 Apr 4.

    PMID: 30954534RESULT

  • Saleme B, Das SK, Zhang Y, Boukouris AE, Lorenzana Carrillo MA, Jovel J, Wagg CS, Lopaschuk GD, Michelakis ED, Sutendra G. p53-Mediated Repression of the PGC1A (PPARG Coactivator 1alpha) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio-oncology. J Am Heart Assoc. 2020 Aug 4;9(15):e017247. doi: 10.1161/JAHA.120.017247. Epub 2020 Jul 29. No abstract available.

    PMID: 32750288RESULT

  • Rudiger A, Dyson A, Felsmann K, Carre JE, Taylor V, Hughes S, Clatworthy I, Protti A, Pellerin D, Lemm J, Claus RA, Bauer M, Singer M. Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis. Clin Sci (Lond). 2013 Mar;124(6):391-401. doi: 10.1042/CS20120334.

    PMID: 22988837RESULT

  • Chagnon F, Coquerel D, Salvail D, Marsault E, Dumaine R, Auger-Messier M, Sarret P, Lesur O. Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction. Crit Care Med. 2017 Apr;45(4):e391-e398. doi: 10.1097/CCM.0000000000002097.

    PMID: 27571457RESULT

  • Coquerel D, Chagnon F, Sainsily X, Dumont L, Murza A, Cote J, Dumaine R, Sarret P, Marsault E, Salvail D, Auger-Messier M, Lesur O. ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock. Crit Care Med. 2017 Nov;45(11):e1139-e1148. doi: 10.1097/CCM.0000000000002639.

    PMID: 28777197RESULT

  • Frier BC, Williams DB, Wright DC. The effects of apelin treatment on skeletal muscle mitochondrial content. Am J Physiol Regul Integr Comp Physiol. 2009 Dec;297(6):R1761-8. doi: 10.1152/ajpregu.00422.2009. Epub 2009 Sep 30.

    PMID: 19793954RESULT

  • Masse MH, Richard MA, D'Aragon F, St-Arnaud C, Mayette M, Adhikari NKJ, Fraser W, Carpentier A, Palanchuck S, Gauthier D, Lanthier L, Touchette M, Lamontagne A, Chenard J, Mehta S, Sansoucy Y, Croteau E, Lepage M, Lamontagne F. Early Evidence of Sepsis-Associated Hyperperfusion-A Study of Cerebral Blood Flow Measured With MRI Arterial Spin Labeling in Critically Ill Septic Patients and Control Subjects. Crit Care Med. 2018 Jul;46(7):e663-e669. doi: 10.1097/CCM.0000000000003147.

    PMID: 29629988RESULT

Biospecimen

Retention: SAMPLES WITHOUT DNA

20 ml of blood

MeSH Terms

Conditions

Shock, Septic

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

SepsisInfectionsSystemic Inflammatory Response SyndromeInflammationPathologic ProcessesPathological Conditions, Signs and SymptomsShock

Intervention Hierarchy (Ancestors)

Specimen HandlingClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisPuncturesSurgical Procedures, OperativeInvestigative Techniques

Study Officials

  • Olivier Lesur, MD PhD

    Centre de recherche du Centre hospitalier universitaire de Sherbrooke

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Olivier Lesur, MD PhD

CONTACT

819-346-1110olivier.lesur@usherbrooke.ca

Frédéric Chagnon, MSc

CONTACT

819-346-1110frederic.chagnon@usherbrooke.ca

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 10, 2022

First Posted

January 24, 2022

Study Start

July 21, 2022

Primary Completion

December 21, 2023

Study Completion

July 21, 2024

Last Updated

July 20, 2023

Record last verified: 2023-07

Locations

CA(1)