Neuromodulation of Motion Illusions (Vection)

NCT05198440 | Unknown

• 1 other identifier: ID/RCB 2019-A03159-48
• Study Type: interventional
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

Virtual reality systems or simulators are more and more frequently used in the field of learning but also in motor rehabilitation. One of the key points of the success of these systems is the experience of "presence" which is associated with the capacity of these technologies to develop in the observer, who is static, the sensation of moving in the virtual environment (vection). However, the simulation generates a sensory conflict (an optical flow specifying self-motion and vestibular stimuli specifying body immobility). This conflict influences the temporal characteristics of the vection and consequently modifies the way users act in their virtual environment. Thus, contrary to a real situation, vection does not occur instantaneously with the appearance of a visual movement. Moreover, the visual stimulus often generates alternating periods of perception of movement of the environment and of oneself (bistable perception) which can lead to "simulator sickness", a disabling situation for the user. Thus, as vection is an essential element to allow an "optimal transfer of learning" from the simulator to reality, it may be important to promote its emergence while limiting its bistability. The aim of this project is to study the inhibitory or facilitative modulation of the emergence of the vection phenomenon by the use of non-invasive cortical stimulation techniques (transcranial electrical stimulation (tES), transcranial alternative current stimulation (tACS), and repeated transcranial magnetic stimulation (rTMS)).

Conditions

Healthy

Keywords

vection; neuromodulation; rTMS; tACS

Outcome Measures

Primary Outcomes (4)

• Change in the latency of first vection between neuromodulations

  Time required for the appearance of a vection before and after neurostimulation (latency in s).

  During the two experimental sessions, at day 1 and up to day 15

• Change in the vection frequency between neuromodulations

  Frequency of vection episodes during a period of visual stimulation before and after neurostimulation (%).

  During the two experimental sessions, at day 1 and up to day 15

• Change in the vection duration between neuromodulations

  Perceived total time experiencing vection during visual stimulation before and after neurostimulation (s).

  During the two experimental sessions, at day 1 and up to day 15

• Change in the vection intensity between neuromodulations

  Intensity of vection before and after neurostimulation (subjective scale from 0 to 10).

  During the two experimental sessions, at day 1 and up to day 15

Secondary Outcomes (3)

• Change in brain activity (as measured by EEG - EP) between neuromodulations

  During the two experimental sessions, at day 1 and up to day 15

• Change in brain activity (as measured by EEG - spectrum) between neuromodulations

  During the two experimental sessions, at day 1 and up to day 15

• Change in brain activity (as measured by EEG - connectivity) between neuromodulations

  During the two experimental sessions, at day 1 and up to day 15

Study Arms (1)

Neuromodulation of vection

EXPERIMENTAL

Device: non-invasive neuromodulation; Device: electroencephalography; Device: anatomical MRI

Interventions

non-invasive neuromodulation DEVICE

The modulations of the vection phenomenon will then be studied over two sessions of 1h30, separated by a minimum of 3 to a maximum of 15 days (the first session will be performed following the MRI). Each session will include: the installation of an EEG headset and the parameterization of the stimulation (30 min), then a phase of recording of the vection with neuromodulation (1h) according to 2 experimental conditions: * Experiment 1: recording of vection at rest (20 min), then during and after neurostimulation by tES (20 min). Active and sham (placebo) stimulation will be tested separately during the two sessions (counterbalanced order). * Experiment 2: recording of vection during neuromodulation by rTMS triggered in real time (1h). Triggering will be based on behavioral response (experiment 2a) or oscillatory activity detection (experiment 2b). Active and sham (placebo) stimulation will be tested in both sessions (randomized order).

Also known as: rTMS, tACS

Neuromodulation of vection

electroencephalography DEVICE

The modulations of the vection phenomenon will then be studied over two sessions of 1h30, separated by a minimum of 3 to a maximum of 15 days (the first session will be performed following the MRI). Each session will include: the installation of an EEG headset and the parameterization of the stimulation (30 min), then a phase of recording of the vection with neuromodulation (1h) according to 2 experimental conditions: * Experiment 1: recording of vection at rest (20 min), then during and after neurostimulation by tES (20 min). Active and sham (placebo) stimulation will be tested separately during the two sessions (counterbalanced order). * Experiment 2: recording of vection during neuromodulation by rTMS triggered in real time (1h). Triggering will be based on behavioral response (experiment 2a) or oscillatory activity detection (experiment 2b). Active and sham (placebo) stimulation will be tested in both sessions (randomized order).

Also known as: EEG

Neuromodulation of vection

anatomical MRI DEVICE

The modulations of the vection phenomenon will then be studied over two sessions of 1h30, separated by a minimum of 3 to a maximum of 15 days (the first session will be performed following the MRI). Each session will include: the installation of an EEG headset and the parameterization of the stimulation (30 min), then a phase of recording of the vection with neuromodulation (1h) according to 2 experimental conditions: * Experiment 1: recording of vection at rest (20 min), then during and after neurostimulation by tES (20 min). Active and sham (placebo) stimulation will be tested separately during the two sessions (counterbalanced order). * Experiment 2: recording of vection during neuromodulation by rTMS triggered in real time (1h). Triggering will be based on behavioral response (experiment 2a) or oscillatory activity detection (experiment 2b). Active and sham (placebo) stimulation will be tested in both sessions (randomized order).

Neuromodulation of vection

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy subjects aged 18 to 40 years
• Right-handed subjects
• Signed informed consent,
• Medical examination performed prior to participation in the research,
• Affiliation to or beneficiary of a social security plan

You may not qualify if:

• Contraindications (CI) to the practice of MRI, EEG, TMS \& tES
• Existence of a severe general condition: cardiac, respiratory, hematological, renal, hepatic, cancerous,
• Regular use of anxiolytics, sedatives, antidepressants, neuroleptics,
• Characterized psychiatric pathology,
• Ingestion of alcohol before the examination,
• Pregnant, parturient or breastfeeding women
• Person deprived of liberty by judicial or administrative decision, person under a legal protection measure (under guardianship or curators)

Sponsors & Collaborators

• University Hospital, Grenoble: lead

MeSH Terms

Interventions

Electroencephalography

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Neurological; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 7, 2021
• First Posted: January 20, 2022
• Study Start: January 30, 2022
• Primary Completion: January 30, 2024
• Study Completion: January 30, 2024
• Last Updated: January 20, 2022

Record last verified: 2022-01