Two-day Bed Rest, Insulin Sensitivity and Muscle Protein Synthesis

NCT03877822 | Withdrawn

• 1 other identifier: 190206/B/05
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

The impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Change in whole-body insulin sensitivity

  Change in whole-body insulin sensitivity via meal tolerance test

  During 2 days of habitual physical activity and 2 days of bed rest. Blood glucose and insulin are monitored for 2 hours following ingestion of a standardized meal

Secondary Outcomes (3)

• Change in cumulative muscle protein synthesis

  During 2 days of habitual physical activity and 2 days of bed rest

• Change in continuous glucose

  Continuous glucose, during the 2 days of habitual activity and 2 days of bed rest

• Change in muscle volume

  Immediately before and immediately after the 2-day bed rest period

Study Arms (1)

Habitual activity and 2 days bed rest

EXPERIMENTAL

Participants will undergo 2 days of habitual activity and 2 days bed rest

Behavioral: Habitual activity; Behavioral: Bed rest

Interventions

Habitual activity BEHAVIORAL

Two days of habitual physical activity, under normal free-living conditions

Habitual activity and 2 days bed rest

Bed rest BEHAVIORAL

Two days of bed rest, to induce whole-body physical inactivity

Habitual activity and 2 days bed rest

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male
• Aged 18-40

You may not qualify if:

• Smoker
• Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes)
• Any diagnosed cardiovascular disease (e.g. deep vein thrombosis or hypertension)
• Chronic use of any prescribed or over the counter pharmaceuticals (that may modulate muscle protein metabolism).
• A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.
• Any known disorders in muscle metabolism
• Regular use of nutritional supplements (i.e. ingestion more than twice per week during the last month)
• Metallic implants (including heart pacemaker, cochlear implants, medication pumps, surgical clips, plates or screws).
• Allergy to lidocaine
• Recent (within the last 6 months) or current musculoskeletal injury (e.g. leg fracture)

Sponsors & Collaborators

• University of Exeter: lead

MeSH Terms

Interventions

Bed Rest

Intervention Hierarchy (Ancestors)

Therapeutics

Study Officials

• Marlou L Dirks, PhD

  University of Exeter

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Participants will firstly undergo 2 days of habitual physical activity, followed by 2 days of bed rest

Study Record Dates

• First Submitted: February 28, 2019
• First Posted: March 18, 2019
• Study Start: September 1, 2021
• Primary Completion: September 1, 2021
• Study Completion: September 1, 2021
• Last Updated: November 17, 2021

Record last verified: 2021-11