NCT05194670

Brief Summary

Comparison of EDOF IOLs versus monofocal IOLs with mini-monovision concerning intermediate and near visual acuity.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
62

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Aug 2017

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2017

Completed
4.4 years until next milestone

First Submitted

Initial submission to the registry

January 4, 2022

Completed
14 days until next milestone

First Posted

Study publicly available on registry

January 18, 2022

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2023

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2024

Completed
Last Updated

January 18, 2022

Status Verified

January 1, 2022

Enrollment Period

6 years

First QC Date

January 4, 2022

Last Update Submit

January 4, 2022

Conditions

Keywords

CataractMyopiaenhanced depth of focus intraocular lensmini-monovision

Outcome Measures

Primary Outcomes (1)

  • Spectacle independence

    Spectacle independence will be assessed using a questionnaire and compared between patients with EDOF IOLs and patients with the monofocal IOL

    24 months

Secondary Outcomes (3)

  • Visual acuity

    24 months

  • Reading speed

    24 months

  • Stereo vision

    24 months

Study Arms (2)

Acunex Vario AN6V

EXPERIMENTAL

Patient will receive the enhanced depth of focus IOL during cataract surgery

Device: enhanced depth of focus IOL

Acunex AN6

EXPERIMENTAL

Patient will receive the monofocal IOL during cataract surgery

Device: monofocal IOL

Interventions

Acunex Vario AN6V, enhanced depth of focus IOL

Acunex Vario AN6V

Acunex AN6, monofocal IOL

Acunex AN6

Eligibility Criteria

Age21 Years - 105 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • age-related cataract in both eyes
  • bilateral cataract surgery
  • motivated to be less spectacle dependent in the intermediate to near vision range
  • expected CDVA of 0.8 snellen or better
  • myopic patients with shorter eye having an axial length of at least 25.5 mm
  • age 21 and older
  • planned postoperative astigmatis lower than or 0.75 D
  • written informed consent prior to recruitment

You may not qualify if:

  • pregnancy (pregnancy test will be taken pre-operatively in women of reproductive age)
  • retinitis pigmentosa
  • chronic uveitis
  • amblyopia
  • pupil decentration \> 0.8 mm, pupil size \< 2.8 mm
  • preceded retinal surgery
  • preceded LASIK
  • any ophthalmic abnormality that could compromise visual function or the measurements

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Vienna Institute for Research in Ocular Surgery (VIROS), Hanusch Hospital Vienna

Vienna, 1140, Austria

RECRUITING

MeSH Terms

Conditions

CataractMyopia

Condition Hierarchy (Ancestors)

Lens DiseasesEye DiseasesRefractive Errors

Study Officials

  • Oliver Findl, MD

    Vienna Institute for Research in Ocular Surgery (VIROS), Hanusch Hospital Vienna

    PRINCIPAL INVESTIGATOR

Central Study Contacts

John Falasinnu, MD

CONTACT

Oliver Findl, MD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

January 4, 2022

First Posted

January 18, 2022

Study Start

August 1, 2017

Primary Completion

August 1, 2023

Study Completion

August 1, 2024

Last Updated

January 18, 2022

Record last verified: 2022-01

Data Sharing

IPD Sharing
Will not share

Locations