NCT06345820

Brief Summary

Comparison of the clinical performance of two enhanced monofocal IOLs with similar design.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
35

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jun 2023

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 28, 2023

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

March 28, 2024

Completed
6 days until next milestone

First Posted

Study publicly available on registry

April 3, 2024

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2025

Completed
Last Updated

April 4, 2024

Status Verified

April 1, 2024

Enrollment Period

1.9 years

First QC Date

March 28, 2024

Last Update Submit

April 3, 2024

Conditions

Keywords

CataractCataract surgeryIntraocular lens

Outcome Measures

Primary Outcomes (1)

  • Monocular intermediate visual acuity

    Monocular intermediate visual acuity at 66 cm will be measured using ETDRS charts

    24 months

Secondary Outcomes (2)

  • Monocular distance visual acuity

    24 months

  • Monocular near visual acuity

    24 months

Study Arms (2)

Evolux

EXPERIMENTAL

Patient will receive the Enova IOL during cataract surgery

Device: Evolux

Tecnis Eyhance

EXPERIMENTAL

Patient will receive the Tecnis Ehance IOL during cataract surgery

Device: Tecnis Eyhance

Interventions

EvoluxDEVICE

Evolux, enhanced monofocal IOL

Evolux

Tecnis Eyhance, enhanced monofocal IOL

Tecnis Eyhance

Eligibility Criteria

Age21 Years - 105 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Bilateral cataract
  • Age 21 or older
  • Visual acuity \> 0.05
  • Axial length: 22.00-26.00mm
  • Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
  • Written informed consent prior to surgery
  • Availability, willingness and sufficient cognitive awareness to comply with examination procedures

You may not qualify if:

  • Active ocular disease (e.g. chronic uveitis, proliferative diabetic retinopathy, chronic glaucoma not responsive to medication)
  • Relevant other ophthalmic diseases such as pseudoexfoliation syndrome (PEX), Intraoperative Floppy Iris Syndrome (IFIS)
  • Corneal decompensation or corneal endothelial cell insufficiency
  • Amblyopia
  • Previous ocular surgery or trauma
  • Persons who are pregnant or nursing (pregnancy test will be taken in women of reproductive age)
  • Astigmatism with the need for a toric IOL

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Vienna Institute for Research in Ocular Surgery (VIROS), Hanusch Hospital, Vienna

Vienna, 1140, Austria

RECRUITING

MeSH Terms

Conditions

Cataract

Condition Hierarchy (Ancestors)

Lens DiseasesEye Diseases

Study Officials

  • Oliver Findl, Prim. Dr.

    Vienna Institute for Research in Ocular Surgery (VIROS), Hanusch Krankenhaus

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Andreas Rotter, MD

CONTACT

Manuel Ruiss, MSc

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

March 28, 2024

First Posted

April 3, 2024

Study Start

June 28, 2023

Primary Completion

June 1, 2025

Study Completion

June 1, 2025

Last Updated

April 4, 2024

Record last verified: 2024-04

Locations