Fitness Assessment in Young Adults Recovered From Lymphoma

NCT05188755 | Completed DMC

• 2 other identifiers: RBHP 2021 KANOLD2021-A02184-37
• Study Type: interventional
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

Regular physical activity (PA) is associated with maintaining body composition, increased cardiorespiratory capacity, muscle mass and bone mineral density. In the event of a cancer, the development of physical capacities and metabolism may therefore be disturbed by cancer, these associated treatments (chemotherapy, radiotherapy and hematopoietic stem cell transplantation) but also undernutrition and the reduction in physical activity or even a sedentary lifestyle. Although the benefits of PA in oncology are now well identified for adult populations, studies are still rare in the population of children, adolescents and young adults, and the results are still difficult to generalize. As a result, there is no recommendation on the practice of physical activity in pediatric oncology or adolescents and young adults and the levels of physical activity of cured patients remain lower than those of the general population. Fitness is a marker of health in adults as well as in adolescents. Physical condition is a set of components such as cardiorespiratory capacity (transport and use of O2), body composition (distribution of bone, muscle and fat masses) and muscle function (strength, power, fatigue, energy metabolism) . The investigators hypothesize that, compared to young adults, recovered from lymphoma are expected to exhibit impaired physical condition, due to physical deconditioning.

Conditions

Young Adults; Lymphoma, Non-Hodgkin; Hodgkin Disease

Keywords

physical fitness; fat oxidation; metabolism; exercise

Outcome Measures

Primary Outcomes (1)

• fat oxidation rate

  maximum rate of lipid oxidation (in mg/ml)

  day at 11:30 am during one day

Secondary Outcomes (14)

• rest metabolism

  at 08:00 am in fasted condition during one day

• blood insulinemia

  at 07:30 am in fasted condition during one day

• blood N-terminal pro-B natriuretic peptide

  at 07:30 am in fasted condition during one day

• blood troponin

  at 07:30 am in fasted condition during one day

• blood lipids

  at 07:30 am in fasted condition during one day

Study Arms (2)

Healthy controls

ACTIVE COMPARATOR

sex and age matched healthy controls

Other: Indirect calorimetric test during submaximal exercise

young adults recovered from lymphoma or Hodgkin's disease

EXPERIMENTAL

young adults recovered from lymphoma or Hodgkin's disease

Other: Indirect calorimetric test during submaximal exercise

Interventions

Indirect calorimetric test during submaximal exercise OTHER

* metabolic evaluation by indirect calorimetry at rest and during exercise * evaluation of cardiac output * peripheral quantitative computed tomography (pQCT) of the muscle cross section * evaluation of body composition * assessment of physical capacity (chair test and 3 min step-test) * blood test * assess the level of physical activity

Also known as: cardiac output, body composition, assessment of physical capacity, blood test, accelerometry, peripheral quantitative computed tomography

Healthy controls; young adults recovered from lymphoma or Hodgkin's disease

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Young adult male or female, aged 18 to 25
• giving free and informed consent
• Hodgkin lymphoma or non-Hodgkin lymphoma in the healing stage
• Cured (defined by an undetectable disease at the end of treatment) for at least one year and maximum 6 years of lymphoma or Hodgkin's disease

You may not qualify if:

• Legal incapable adults
• People under judicial protection
• Treatment with systemic glucocorticoids for more than a week, during the 30 days preceding the tests
• Medical contraindication to the practice of physical exercise
• Any pathologies (other than the history of lymphoma for the cases) likely to affect the metabolism or the muscle mass
• Any treatment that may have an influence on the energy metabolism
• Active infection
• Pregnant, breastfeeding, or likely to be
• Subject's refusal to participate

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand: lead

Study Sites (1)

CHU de Clermont-Ferrand

Clermont-Ferrand, 63000, France

Location

MeSH Terms

Conditions

Lymphoma, Non-Hodgkin; Hodgkin Disease; Motor Activity

Interventions

Cardiac Output; Body Composition; Hematologic Tests; Accelerometry

Condition Hierarchy (Ancestors)

Lymphoma; Neoplasms by Histologic Type; Neoplasms; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases; Behavior

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Hemodynamics; Cardiovascular Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena; Biochemical Phenomena; Chemical Phenomena; Metabolism; Body Constitution; Physiological Phenomena; Clinical Laboratory Techniques; Investigative Techniques

Study Officials

• Justina Kanold

  University Hospital, Clermont-Ferrand

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: group 1: healthy controls group 2 : young adults recovered from lymphoma or Hodgkin's disease

Study Record Dates

• First Submitted: November 29, 2021
• First Posted: January 12, 2022
• Study Start: January 1, 2022
• Primary Completion: December 6, 2022
• Study Completion: December 6, 2022
• Last Updated: December 23, 2022

Record last verified: 2021-11

Locations

FR (1)