Ultrasonographic Diameter of Optic Nerve Sheath in Fluid Assessment in Severe Preeclamptic Patients

NCT05176652 | Unknown

• 1 other identifier: Soh-Med-21-12-21
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 3

Brief Summary

Changes in the optic nerve sheath diameter detected by ultrasound are considered an important manifestation of increased intracranial pressure . The normal optic nerve sheath diameter measures up to 5.0 mm and an average optic nerve sheath diameter more than 5 mm is considered abnormal and elevated intracranial pressure should be suspected.Cerebral edema have been demonstrated in 71% to 100% of magnetic resonance imaging in preeclamptic patients and an increase in optic nerve sheath diameter has been described in preeclamptic females compared to healthy pregnant females Therefore, Increased optic nerve sheath diameter can indirectly reflect the state of intracranial edema that could be a part of generalized edema of preeclampsia and it could be a possible marker of generalized tissue edema and fluid overload in these patients.

Conditions

Severe Pre-eclampsia

Outcome Measures

Primary Outcomes (1)

• correlation between optic nerve sheath diameter and extravascular lung water

  correlation between ultrasound assessment of optic nerve sheath diameter and extravascular lung water

  up to 24 hours

Interventions

ultrasound RADIATION

ultrasonographic assessment of optic nerve sheath diameter

Eligibility Criteria

• Age: 18 Years - 40 Years
• Gender Eligibility Details: pregnant preeclamptic patients
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

severe preeclamptic patients (aged 18-40) after termination of pregnancy

You may qualify if:

• Systolic blood pressure of 160mm Hg or higher, or diastolic blood pressure of 110mm Hg or higher on 2 occasions at least 6 hours apart on bed rest.
• Proteinuria ≥5g in a 24 hour urine specimen or ≥3+ on 2 random urine samples collected at least 4 hours apart.
• patient acceptance
• Accepted mental state of the patients

You may not qualify if:

• patient refusal to participate in the study
• chronic kidney disease
• chronic pulmonary disease
• chronic cardiac disease
• chronic hypertension
• previous ocular operation and diseases

Sponsors & Collaborators

• Sohag University: lead

Study Sites (3)

Hossam Eldin Hassan Ahmed Abdelghani

Sohag, 82511, Egypt

RECRUITING

Hossam Eldin Hassan Ahmed Abdelghani

Sohag, Egypt

RECRUITING

Hossam Eldin Hassan Ahmed Abdelghani

Sohag, Egypt

RECRUITING

MeSH Terms

Conditions

Pre-Eclampsia

Interventions

High-Energy Shock Waves

Condition Hierarchy (Ancestors)

Hypertension, Pregnancy-Induced; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Intervention Hierarchy (Ancestors)

Ultrasonic Waves; Sound; Radiation, Nonionizing; Radiation; Physical Phenomena

Central Study Contacts

Hossam Eldin Hassan ahmed, assisstant lecturer

CONTACT

01000393835; hossamhassan01000393835@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assisstant lecturer of anesthesia and ICU ,faculty of medicine at sohag university

Study Record Dates

• First Submitted: December 14, 2021
• First Posted: January 4, 2022
• Study Start: December 6, 2021
• Primary Completion: October 6, 2022
• Study Completion: December 6, 2022
• Last Updated: January 4, 2022

Record last verified: 2021-12

Locations

EG (3)