NCT05154266

Brief Summary

Meta-analyses have demonstrated that mindfulness-based programmes are more effective than no treatment across different populations and desired outcomes yet there is limited evidence on how to sustain these benefits beyond the traditional eight-week courses. The 'Taking it Further' (TiF) programme was developed by the University of Oxford Mindfulness Centre to help reinforce and deepen one's mindfulness practice to promote well-being and mental health for life. The proposed study aims to evaluate the effectiveness of this programme in graduates of MBCT/MBSR on well-being and mental health outcomes and explore the mediators (i.e. mindfulness, decentring, and self-compassion) through which this programme has an effect over the course of twelve weeks using a randomised controlled trial with a waitlist control. The planned research is part of an overall effort to optimize treatment effects and the long-term effectiveness of mindfulness-based programmes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
168

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jun 2021

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 28, 2021

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

November 29, 2021

Completed
14 days until next milestone

First Posted

Study publicly available on registry

December 13, 2021

Completed
8 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 21, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 21, 2021

Completed
Last Updated

January 13, 2022

Status Verified

January 1, 2022

Enrollment Period

6 months

First QC Date

November 29, 2021

Last Update Submit

January 11, 2022

Conditions

Mindfulness

Keywords

Mindfulness-Based Cognitive TherapyMechanismMediatorWell-beingMental health

Outcome Measures

Primary Outcomes (1)

  • Change in Well-being

    To explore the effects of the TiF programme on well-being over time, the 14-item Warwick-Edinburgh Mental Well-being Scale (WEMWBS) will be used.

    Pre-intervention (~2 weeks and 1 week before Week 0), Week 0, Week 4, Week 8, Week 12 (Post-intervention)

Secondary Outcomes (6)

  • Change in Mindfulness

    Pre-intervention (~2 weeks and 1 week before Week 0), Week 0, Week 4, Week 8, Week 12 (Post-intervention)

  • Change in Psychological Quality of Life

    Week 0, Week 4, Week 8, Week 12 (Post-intervention)

  • Change in Depression

    Week 0, Week 4, Week 8, Week 12 (Post-intervention)

  • Change in Anxiety

    Week 0, Week 4, Week 8, Week 12 (Post-intervention)

  • Change in Self-compassion

    Week 0, Week 4, Week 8, Week 12 (Post-intervention)

  • +1 more secondary outcomes

Other Outcomes (7)

  • Amount of mindfulness practice

    Week 4, Week 8, Week 12 (Post-intervention)

  • Change in quality of mindfulness practice

    Week 4, Week 8, Week 12 (Post-intervention)

  • Change in side effects of mindfulness practice

    Week 4, Week 8, Week 12 (Post-intervention)

  • +4 more other outcomes

Study Arms (2)

Mindfulness Programme

EXPERIMENTAL

Participants randomized to the mindfulness programme were invited to complete a twelve-week programme called 'Taking it Further'.

Behavioral: Taking it Further

Waitlist Control

NO INTERVENTION

Participants randomized to the waitlist control were asked to carry on as usual and were offered the Taking it Further course at a later time. No data was collected when the waitlist control group took part in the TiF programme.

Interventions

Taking it FurtherBEHAVIORAL

This programme is offered to individuals who have already completed a Mindfulness-Based Cognitive Therapy (MBCT) or Mindfulness-Based Stress Reduction Programme (MBSR). In this programme, participants explore weekly themes (i.e. 'Responding not reacting' and 'Taking care of ourselves, taking care of others'). These themes reinforce the learning from the eight-week MBCT/MBSR courses whilst also providing new learning opportunities. The programme makes some of the dimensions that are implicit in MBCT/MBSR more explicit; for example, the cultivation of attitudes of mindfulness (such as equanimity, joy, and kindness). These attitudes of mindfulness require a foundational mindfulness practice and thus this is an additive learning theme from traditional MBCT/MBSR programmes.

Mindfulness Programme

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • English-speaking
  • Has access to computer for online mindfulness sessions and assessments
  • Participants who have completed an MBSR and/or MBCT course in the past

You may not qualify if:

  • Has taken TiF programme prior to the start of the study
  • Has completed a mindfulness programme that does not fit within the parameters of a formal mindfulness-based programme.
  • Those that have recently experienced a traumatic event or bereavement and/or has been abusing substances to manage stress and/or has been harming themselves recently
  • Participants on mindfulness teacher training pathway

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Oxford

Oxford, Oxfordshire, OX3 7JX, United Kingdom

Location

Related Publications (3)

  • Montero-Marin J, Farley ER, Maloney S, Crane R, D'Alton P, Eldridge R, Giommi F, Griffith G, Hecht FM, Hinze V, Loucks EB, Strauss C, Taylor L, Baer R, Kuyken W. Participants' Perspective on the Competence of Mindfulness-Based Interventions Teaching: Development and Validation of the Mindfulness-Based Interventions-Participants' Assessment of Teaching (MBI:PAT) Questionnaire. Mindfulness (N Y). 2025;16(10):2825-2844. doi: 10.1007/s12671-025-02668-8. Epub 2025 Sep 3.

    PMID: 41322157DERIVED

  • Maloney S, Montero-Marin J, Kuyken W. Mindfulness-Based Cognitive Therapy-Taking it Further (MBCT-TiF) compared to Ongoing Mindfulness Practice (OMP) in the promotion of well-being and mental health: A randomised controlled trial with graduates of MBCT and MBSR. Behav Res Ther. 2024 Feb;173:104478. doi: 10.1016/j.brat.2024.104478. Epub 2024 Jan 6.

    PMID: 38244384DERIVED

  • Maloney S, Montero-Marin J, Kuyken W. Pathways to mental well-being for graduates of mindfulness-based cognitive therapy (MBCT) and mindfulness-based stress reduction (MBSR): A mediation analysis of an RCT. Psychother Res. 2024 Nov;34(8):1162-1173. doi: 10.1080/10503307.2023.2269299. Epub 2023 Nov 6.

    PMID: 37931304DERIVED

MeSH Terms

Conditions

Psychological Well-Being

Condition Hierarchy (Ancestors)

Personal SatisfactionBehavior

Study Officials

  • Willem Kuyken

    University of Oxford

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
The experimenter was unaware of who was allocated to the treatment or control group during data collection and analysis. A researcher external to data collection and analysis was in charge of randomization.
Purpose
OTHER
Intervention Model
PARALLEL
Model Details: Wait-list control
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

November 29, 2021

First Posted

December 13, 2021

Study Start

June 28, 2021

Primary Completion

December 21, 2021

Study Completion

December 21, 2021

Last Updated

January 13, 2022

Record last verified: 2022-01

Data Sharing

IPD Sharing
Will not share

Locations

GB(1)