Effect of Ginger Extract on Postprandial Glycaemia of Healthy Adults and Its Antioxidant Properties

NCT05152745 | Completed

• 1 other identifier: 519ginger
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Hyperglycemia is a risk factor to disease development, namely, diabetes mellitus. The blood glucose level management, particularly on post-prandial period has an important role in the prevention of different diseases. Ginger is a specie that has been demonstrated a benefit effect on glycaemia on diabetes. Aim: The aim of this study was 1) to investigate the effects of ginger infusion in the glycaemic response in nondiabetic adults; 2) to evaluate total phenolic content the antioxidant activity of Ginger (Zingiber officinale Roscoe) aqueous extracts. Methodology: 24 nondiabetic subjects were randomly allocated into two groups: intervention group (GI; n=15) and control group (GC; n=15). An oral glucose solution (OGTT) and an OGTT following ginger extract solution were administrated in control and intervention groups, respectively. Blood glucose levels were measurement at fasting and after 30, 60, 90 and 120 minutes after interventions in both groups. Total phenolic content and flavonoids compounds determination of the aqueous ginger extract was determined according to Prabha method. Antioxidant activity was also measured through ABTS method and free radicals inhibition capacity. Repeated Measures ANOVA of mixed type and independent samples t-test were used in statistical analysis.

Conditions

Hyperglycemia, Postprandial

Keywords

Ginger, hyperglycemia, antioxidant, phenols, flavonoids

Outcome Measures

Primary Outcomes (6)

• Postprandial blood glucose levels time curve

  Mean blood glucose levels (mmol/L) obtained after oral glucose tolerance test in control group and after oral glucose tolerance test plus baobab extract in intervention group at different moments

  up to 120 minutes after intervention

• Incremental area under the curve of glucose levels

  the blood glucose incremental area under the curve (AUCi) of each participant was defined using the GraphPad Prism program (version 5.0).

  At 120 minutes after intervention

• Blood glucose maximum concentrations

  Mean blood glucose levels (mmol/L)

  At 60 minutos after intervention

• Antioxidant activity determination of Ginger extract

  Mean values of anion and radical inhibition capacity and mean values of antioxidant capacity by ABTS (micromol TE/g)

  At baseline

• Total phenolic compounds

  Mean values of total phenolic compounds (mg of gallic acid/g ginger)

  At baseline

• Flavonoids

  Mean values of flavonoids (mg quercetin of/g ginger)

  At baseline

Secondary Outcomes (3)

• Weight of participants

  At baseline

• Body mass index of participants

  At baseline

• Height of participants

  At baseline

Study Arms (2)

Placebo (OGTT)

PLACEBO COMPARATOR

The control group participants ingested glucose solution alone (OGTT) prepared with 75 g of anhydrous oral glucose as prescribed by the ADA, dissolved in 200 ml of water.

Other: Placebo OGGT

Intervention (OGTT plus Ginger extract)

EXPERIMENTAL

The intervention group ingested glucose solution followed by 100 ml of ginger aqueous extract (0.2g ginger, each dose).

Other: Ginger aqueous extract

Interventions

Placebo OGGT OTHER

After overnight fasting, blood glucose level was assessed through a capillary drop blood The control group participants ingested glucose solution alone (OGTT) prepared with 75 g of anhydrous oral glucose as prescribed by the ADA, dissolved in 200 ml of water. Blood glucose level was also measured at 30 (t30), 60 (t60), 90 (t90) and 120 (t120) minutes immediately after intervention, for each participant, in control and intervention groups. Glucometer equipment, strips for glucose meters (One Touch Select Plus) and sterilized lancets (Sarstedt normal 21G) were used to measure blood glucose concentrations, taking due care of safety and asepsis.

Placebo (OGTT)

Ginger aqueous extract OTHER

After overnight fasting, blood glucose level was assessed through a capillary drop blood The intervention group participants ingested glucose solution alone (OGTT) prepared with 75 g of anhydrous oral glucose as prescribed by the ADA, dissolved in 200 ml of water, followed by 100mL of ginger extract (0.2g). Blood glucose level was also measured at 30 (t30), 60 (t60), 90 (t90) and 120 (t120) minutes immediately after intervention, for each participant, in control and intervention groups. Glucometer equipment, strips for glucose meters (One Touch Select Plus) and sterilized lancets (Sarstedt normal 21G) were used to measure blood glucose concentrations, taking due care of safety and asepsis.

Intervention (OGTT plus Ginger extract)

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• subjects without glucose metabolism alteration

You may not qualify if:

• medication for glycemia
• had gastrointestinal symptoms or disease
• pregnancy or lactation
• had allergy to ginger.
• to ingest ginger at the day before the intervention.

Sponsors & Collaborators

• Egas Moniz - Cooperativa de Ensino Superior, CRL: lead

Study Sites (1)

Instituto Universitário Egas Moniz

Almada, Monte de Caparica, 2829-511, Portugal

Location

MeSH Terms

Conditions

Hyperglycemia

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Maria Fernanda Mesquita

  Centro de Investigação Interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, Portugal

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 29, 2021
• First Posted: December 10, 2021
• Study Start: May 5, 2017
• Primary Completion: July 30, 2017
• Study Completion: October 30, 2017
• Last Updated: December 10, 2021

Record last verified: 2021-11

Locations

PT (1)