SMS HPV Vaccine Reminders

NCT05151367 | Completed Results

• 2 other identifiers: AAAT15721R21CA253604-01
• Study Type: interventional
• Target: 154
• Locations: 2 countries
• Sites: 2

Brief Summary

This study will take place at health centres and their affiliated schools and community immunization centers overseen by the Kampala Capital City Authority (KCCA) as well as at the Makerere/Mulago/Columbia Adolescent Health Clinic, also in Kampala. While text messages can be used in populations with low literacy, families can opt to receive automated phone call reminders instead. The investigators will pilot assess the impact of vaccine reminders on human papillomavirus (HPV) vaccination. Caregivers of preteens/adolescents will be randomized and stratified by site, language and HPV vaccine dose needed (initiation vs. completion). As this is a feasibility trial, the investigators expect to measure effect size but not necessarily achieve statistical significance.

Conditions

Human Papillomavirus Vaccination

Keywords

Human papillomavirus; Vaccination; Text message; SMS; mHealth; Reminder; Uganda

Outcome Measures

Primary Outcomes (1)

• Number of Participants Who Received the Next HPV Vaccine Dose

  Timeliness of vaccination will be measured by the number of participants who received the next HPV vaccine dose.

  Up to 6 months from randomization

Study Arms (2)

Text message reminders

EXPERIMENTAL

Text message reminders

Behavioral: Text message reminder

Usual Care

NO INTERVENTION

No reminders

Interventions

Text message reminder BEHAVIORAL

Receipt of text messages notifying when the next HPV vaccine dose is due (either first or second)

Text message reminders

Eligibility Criteria

• Age: 10 Years - 14 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Be a parenting adult of an adolescent girl aged 10-14 years
• Reside in Kampala and/or the surrounding districts
• Speak English or Luganda
• Have a cell phone with text messaging capability
• Must have ability to consent

You may not qualify if:

• Parenting adult speaks other language than English or Luganda only
• Parenting adult already enrolled in the study for another child
• Participation in pretesting activities

Sponsors & Collaborators

• Columbia University: lead
• Makerere University: collaborator
• National Cancer Institute (NCI): collaborator

Study Sites (2)

Columbia University Irving Medical Center

New York, New York, 10032, United States

Location

Makerere University/Mulago Hospital

Kampala, Uganda

Location

Related Publications (1)

• Kitaka SB, Rujumba J, Zalwango SK, Pfeffer B, Kizza L, Nattimba JP, Stephens AB, Nabukeera-Barungi N, Wynn CS, Babirye JN, Mukisa J, Mupere E, Stockwell MS. SEARCH Study: Text Messages and Automated Phone Reminders for HPV Vaccination in Uganda: Randomized Controlled Trial. JMIR Mhealth Uhealth. 2025 May 5;13:e63527. doi: 10.2196/63527.

  PMID: 40324213 DERIVED

Results Point of Contact

• Title: Melissa Stockwell
• Organization: Columbia University

mss2112@cumc.columbia.edu

2123425732

Study Officials

• Melissa S. Stockwell, MD, MPH

  Columbia University

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Pediatrics and Population and Family Health

Study Record Dates

• First Submitted: November 26, 2021
• First Posted: December 9, 2021
• Study Start: February 23, 2022
• Primary Completion: October 30, 2022
• Study Completion: December 31, 2022
• Last Updated: July 8, 2024
• Results First Posted: July 8, 2024

Record last verified: 2024-07

Locations

US (1); UG (1)