S1105: Text-Messaging Intervention to Reduce Early Discontinuation of AI Therapy in Women With Early-Stage Breast Cancer
S1105, Randomized Trial Of Text-Messaging Intervention To Reduce Early Discontinuation Of Adjuvant Aromatase Inhibitor Therapy In Women With Early Stage Breast Cancer
3 other identifiers
interventional
724
1 country
204
Brief Summary
RATIONALE: Measuring how text-message affects treatment compliance in women with breast cancer may help doctors plan the best treatment. PURPOSE: This randomized trial studies how well text-message works in reducing early discontinuation of aromatase inhibitor therapy in patients with early-stage breast cancer who underwent breast surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable breast-cancer
Started May 2012
Longer than P75 for not_applicable breast-cancer
204 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 21, 2012
CompletedFirst Posted
Study publicly available on registry
January 24, 2012
CompletedStudy Start
First participant enrolled
May 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2018
CompletedMarch 8, 2018
March 1, 2018
5.7 years
January 21, 2012
March 6, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Time to first evidence of adherence failure (discontinuation)
Every 3 months after randomization
Secondary Outcomes (4)
Adherence effect of text message compared to usual care using the patient self-report responses to AI Usage form
Every 3 months after randomization
Relationship between randomized arm and various participant, site and health insurance characteristics
Every 3 months after randomization
Reasons for early discontinuation of AI therapy among intervention arm and control arm as assessed by quality-of-life questionnaires
Every 3 months after randomization
Time to last evidence of adherence
Every 3 months after randomization
Study Arms (2)
Text message reminder
EXPERIMENTALPatients undergo a text message education checklist involving confirmation of cellular telephone capability to receive text messages, how to retrieve and read messages, including a confirmation evaluation, at baseline and at any time a patient obtains a new cellular telephone. Patients then receive a text message twice a week at 8 o'clock in the morning (for each time zone) for up to 3 years. Additionally, patients receive standard follow-up care.
No text message reminder
NO INTERVENTIONPatients receive standard follow-up care.
Interventions
Eligibility Criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- SWOG Cancer Research Networklead
- National Cancer Institute (NCI)collaborator
Study Sites (204)
Alaska Regional Hospital Cancer Center
Anchorage, Alaska, 99508, United States
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
Fort Smith, Arkansas, 72903, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
Kaiser Permanente - Deer Valley
Antioch, California, 94531, United States
Kaiser Permanente - Fremont
Fremont, California, 94538, United States
California Cancer Center - Woodward Park Office
Fresno, California, 93720, United States
Kaiser Permanente Fresno Medical Center
Fresno, California, 93720, United States
Kaiser Permanente Medical Center - Hayward
Hayward, California, 94545, United States
Kaiser Permanente Medical Center - Oakland
Oakland, California, 94611, United States
Kaiser Permanente Medical Center - Redwood City
Redwood City, California, 94063, United States
Kaiser Permanente Medical Center - Richmond
Richmond, California, 94801, United States
Kaiser Permanente Medical Center - Roseville
Roseville, California, 95661, United States
South Sacramento Kaiser-Permanente Medical Center
Sacramento, California, 95823, United States
Kaiser Permanente Medical Center - Sacramento
Sacramento, California, 95825, United States
Kaiser Permanente Medical Center - San Francisco Geary Campus
San Francisco, California, 94115, United States
Kaiser Permanente Medical Center - Santa Teresa
San Jose, California, 95119, United States
Kaiser Foundation Hospital - San Rafael
San Rafael, California, 94903, United States
Kaiser Permanente Medical Center - Santa Clara Kiely Campus
Santa Clara, California, 95051, United States
Kaiser Permanente Medical Center - Santa Rosa
Santa Rosa, California, 95403, United States
Kaiser Permanente Medical Center - South San Francisco
South San Francisco, California, 94080, United States
Kaiser Permanente Medical Facility - Stockton
Stockton, California, 95210, United States
Kaiser Permanente Medical Center - Vacaville
Vacaville, California, 95688, United States
Kaiser Permanente Medical Center - Vallejo
Vallejo, California, 94589, United States
Kaiser Permanente Medical Center - Walnut Creek
Walnut Creek, California, 94596, United States
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
Hartford, Connecticut, 06105, United States
Cancer Research Center of Hawaii
Honolulu, Hawaii, 96813, United States
OnCare Hawaii, Incorporated - Lusitana
Honolulu, Hawaii, 96813, United States
Queen's Cancer Institute at Queen's Medical Center
Honolulu, Hawaii, 96813, United States
Straub Clinic and Hospital, Incorporated
Honolulu, Hawaii, 96813, United States
OnCare Hawaii, Incorporated - Kuakini
Honolulu, Hawaii, 96817-3169, United States
Kuakini Medical Center
Honolulu, Hawaii, 96817, United States
Kaiser Permanente - Moanalua Medical Center and Clinic
Honolulu, Hawaii, 96819, United States
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, 96826, United States
Tripler Army Medical Center
Honolulu, Hawaii, 96859, United States
Castle Medical Center
Kailua, Hawaii, 96734, United States
Kauai Medical Clinic
Lihue, Hawaii, 96766, United States
Kapiolani Medical Center at Pali Momi
‘Aiea, Hawaii, 96701, United States
Oncare Hawaii, Incorporated - Pali Momi
‘Aiea, Hawaii, 96701, United States
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
Boise, Idaho, 83706, United States
Decatur Memorial Hospital Cancer Care Institute
Decatur, Illinois, 62526, United States
Sherman Hospital
Elgin, Illinois, 60123, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center
Maywood, Illinois, 60153, United States
Good Samaritan Regional Health Center
Mount Vernon, Illinois, 62864, United States
Regional Cancer Center at Memorial Medical Center
Springfield, Illinois, 62781-0001, United States
St. Francis Hospital and Health Centers - Beech Grove Campus
Beech Grove, Indiana, 46107, United States
Reid Hospital & Health Care Services
Richmond, Indiana, 47374, United States
Genesis Regional Cancer Center at Genesis Medical Center
Davenport, Iowa, 52803, United States
Cancer Center of Kansas, PA - Chanute
Chanute, Kansas, 66720, United States
Cancer Center of Kansas, PA - Dodge City
Dodge City, Kansas, 67801, United States
Cancer Center of Kansas - Fort Scott
Fort Scott, Kansas, 66701, United States
Cancer Center of Kansas-Independence
Independence, Kansas, 67301, United States
Cancer Center of Kansas, PA - Kingman
Kingman, Kansas, 67068, United States
Lawrence Memorial Hospital
Lawrence, Kansas, 66044, United States
Cancer Center of Kansas, PA - Liberal
Liberal, Kansas, 67901, United States
Cancer Center of Kansas, PA - Newton
Newton, Kansas, 67114, United States
Cancer Center of Kansas, PA - Parsons
Parsons, Kansas, 67357, United States
Cancer Center of Kansas, PA - Pratt
Pratt, Kansas, 67124, United States
Cancer Center of Kansas, PA - Salina
Salina, Kansas, 67401, United States
Cotton-O'Neil Cancer Center
Topeka, Kansas, 66606, United States
Cancer Center of Kansas, PA - Wellington
Wellington, Kansas, 67152, United States
Associates in Womens Health, PA - North Review
Wichita, Kansas, 67208, United States
Cancer Center of Kansas, PA - Medical Arts Tower
Wichita, Kansas, 67208, United States
Cancer Center of Kansas, PA - Wichita
Wichita, Kansas, 67214, United States
CCOP - Wichita
Wichita, Kansas, 67214, United States
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, 67214, United States
Cancer Center of Kansas, PA - Winfield
Winfield, Kansas, 67156, United States
Highland Clinic
Shreveport, Louisiana, 71105, United States
Feist-Weiller Cancer Center at Louisiana State University Health Sciences
Shreveport, Louisiana, 71130-3932, United States
Boston University Cancer Research Center
Boston, Massachusetts, 02118, United States
Saint Joseph Mercy Cancer Center
Ann Arbor, Michigan, 48106-0995, United States
CCOP - Michigan Cancer Research Consortium
Ann Arbor, Michigan, 48106, United States
Battle Creek Health System Cancer Care Center
Battle Creek, Michigan, 49017, United States
Mecosta County Medical Center
Big Rapids, Michigan, 49307, United States
Oakwood Cancer Center at Oakwood Hospital and Medical Center
Dearborn, Michigan, 48123-2500, United States
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit, Michigan, 48202, United States
Genesys Hurley Cancer Institute
Flint, Michigan, 48503, United States
Hurley Medical Center
Flint, Michigan, 48503, United States
Butterworth Hospital at Spectrum Health
Grand Rapids, Michigan, 49503, United States
CCOP - Grand Rapids
Grand Rapids, Michigan, 49503, United States
Lacks Cancer Center at Saint Mary's Health Care
Grand Rapids, Michigan, 49503, United States
Van Elslander Cancer Center at St. John Hospital and Medical Center
Grosse Pointe Woods, Michigan, 48236, United States
Foote Memorial Hospital
Jackson, Michigan, 49201, United States
Sparrow Regional Cancer Center
Lansing, Michigan, 48912-1811, United States
St. Mary Mercy Hospital
Livonia, Michigan, 48154, United States
Mercy General Health Partners
Muskegon, Michigan, 49444, United States
St. Joseph Mercy Oakland
Pontiac, Michigan, 48341-2985, United States
Mercy Regional Cancer Center at Mercy Hospital
Port Huron, Michigan, 48060, United States
Spectrum Health Reed City Hospital
Reed City, Michigan, 49677, United States
Seton Cancer Institute at Saint Mary's - Saginaw
Saginaw, Michigan, 48601, United States
Providence Cancer Institute at Providence Hospital - Southfield Campus
Southfield, Michigan, 48075, United States
Munson Medical Center
Traverse City, Michigan, 49684, United States
St. John Macomb Hospital
Warren, Michigan, 48093, United States
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703, United States
Mercy Clinic Cancer and Hematology - Rolla
Rolla, Missouri, 65401, United States
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, 65802, United States
St. John's Regional Health Center
Springfield, Missouri, 65804, United States
Hulston Cancer Center at Cox Medical Center South
Springfield, Missouri, 65807, United States
Midwest Hematology Oncology Group, Incorporated
St Louis, Missouri, 63109, United States
CCOP - St. Louis-Cape Girardeau
St Louis, Missouri, 63141, United States
David C. Pratt Cancer Center at St. John's Mercy
St Louis, Missouri, 63141, United States
CCOP - Montana Cancer Consortium
Billings, Montana, 59101, United States
St. Vincent Healthcare Cancer Care Services
Billings, Montana, 59101, United States
Hematology-Oncology Centers of the Northern Rockies - Billings
Billings, Montana, 59102, United States
Billings Clinic - Downtown
Billings, Montana, 59107-7000, United States
Bozeman Deaconess Cancer Center
Bozeman, Montana, 59715, United States
Great Falls Clinic - Main Facility
Great Falls, Montana, 59405, United States
Sletten Cancer Institute at Benefis Healthcare
Great Falls, Montana, 59405, United States
St. Peter's Hospital
Helena, Montana, 59601, United States
Glacier Oncology, PLLC
Kalispell, Montana, 59901, United States
Kalispell Regional Medical Center
Kalispell, Montana, 59901, United States
Montana Cancer Specialists at Montana Cancer Center
Missoula, Montana, 59807-7877, United States
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
Missoula, Montana, 59807, United States
Good Samaritan Cancer Center at Good Samaritan Hospital
Kearney, Nebraska, 68848-1990, United States
Lovelace Medical Center - Downtown
Albuquerque, New Mexico, 87102, United States
Hematology Oncology Associates, PC
Albuquerque, New Mexico, 87106, United States
Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital
Albuquerque, New Mexico, 87110, United States
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87131-5636, United States
New Mexico Cancer Care Associates
Santa Fe, New Mexico, 87505, United States
Falck Cancer Center at Arnot Ogden Medical Center
Elmira, New York, 14905, United States
Tucker Center for Cancer Care at Orange Regional Medical Center
Middletown, New York, 10940-4199, United States
Winthrop University Hospital
Mineola, New York, 11501, United States
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
New York, New York, 10032, United States
Highland Hospital of Rochester
Rochester, New York, 14620, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, 14642, United States
Waverly Hematology Oncology
Cary, North Carolina, 27518, United States
Wayne Memorial Hospital, Incorporated
Goldsboro, North Carolina, 27534, United States
Pardee Memorial Hospital
Hendersonville, North Carolina, 28791, United States
Iredell Memorial Hospital
Statesville, North Carolina, 28677, United States
Forsyth Regional Cancer Center at Forsyth Medical Center
Winston-Salem, North Carolina, 27103, United States
McDowell Cancer Center at Akron General Medical Center
Akron, Ohio, 44307, United States
Adena Regional Medical Center
Chillicothe, Ohio, 45601, United States
Riverside Methodist Hospital Cancer Care
Columbus, Ohio, 43214-3998, United States
CCOP - Columbus
Columbus, Ohio, 43215, United States
Grant Medical Center Cancer Care
Columbus, Ohio, 43215, United States
Mount Carmel Health - West Hospital
Columbus, Ohio, 43222, United States
Doctors Hospital at Ohio Health
Columbus, Ohio, 43228, United States
Grandview Hospital
Dayton, Ohio, 45405, United States
Good Samaritan Hospital
Dayton, Ohio, 45406, United States
David L. Rike Cancer Center at Miami Valley Hospital
Dayton, Ohio, 45409, United States
Samaritan North Cancer Care Center
Dayton, Ohio, 45415, United States
CCOP - Dayton
Dayton, Ohio, 45420, United States
Grady Memorial Hospital
Delaware, Ohio, 43015, United States
Blanchard Valley Medical Associates
Findlay, Ohio, 45840, United States
Middletown Regional Hospital
Franklin, Ohio, 45005-1066, United States
Wayne Hospital
Greenville, Ohio, 45331, United States
Charles F. Kettering Memorial Hospital
Kettering, Ohio, 45429, United States
Fairfield Medical Center
Lancaster, Ohio, 43130, United States
Strecker Cancer Center at Marietta Memorial Hospital
Marietta, Ohio, 45750, United States
Knox Community Hospital
Mount Vernon, Ohio, 43050, United States
Licking Memorial Cancer Care Program at Licking Memorial Hospital
Newark, Ohio, 43055, United States
Southern Ohio Medical Center Cancer Center
Portsmouth, Ohio, 45662, United States
Community Hospital of Springfield and Clark County
Springfield, Ohio, 45505, United States
UVMC Cancer Care Center at Upper Valley Medical Center
Troy, Ohio, 45373-1300, United States
Mount Carmel St. Ann's Cancer Center
Westerville, Ohio, 43081, United States
United States Air Force Medical Center - Wright-Patterson
Wright-Patterson Air Force Base, Ohio, 45433-5529, United States
Ruth G. McMillan Cancer Center at Greene Memorial Hospital
Xenia, Ohio, 45385, United States
Genesis - Good Samaritan Hospital
Zanesville, Ohio, 43701, United States
Clackamas Radiation Oncology Center
Clackamas, Oregon, 97015, United States
Providence Milwaukie Hospital
Milwaukie, Oregon, 97222, United States
Providence Newberg Medical Center
Newberg, Oregon, 97132, United States
Willamette Falls Hospital
Oregon City, Oregon, 97045, United States
Providence Cancer Center at Providence Portland Medical Center
Portland, Oregon, 97213-2967, United States
CCOP - Columbia River Oncology Program
Portland, Oregon, 97225, United States
Providence St. Vincent Medical Center
Portland, Oregon, 97225, United States
Kaiser Permanente Health Care - Portland
Portland, Oregon, 97227, United States
Bon Secours St. Francis Health System
Greenville, South Carolina, 29601, United States
Cancer Centers of the Carolinas - Faris Road
Greenville, South Carolina, 29605, United States
Cancer Centers of the Carolinas - Grove Commons
Greenville, South Carolina, 29605, United States
CCOP - Greenville
Greenville, South Carolina, 29615, United States
Cancer Centers of the Carolinas - Greer Medical Oncology
Greer, South Carolina, 29650, United States
Cancer Centers of the Carolinas - Seneca
Seneca, South Carolina, 29672, United States
CCOP - Upstate Carolina
Spartanburg, South Carolina, 29303, United States
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
Spartanburg, South Carolina, 29303, United States
Cancer Centers of the Carolinas - Spartanburg
Spartanburg, South Carolina, 29307, United States
Brooke Army Medical Center
Fort Sam Houston, Texas, 78234-6200, United States
American Fork Hospital
American Fork, Utah, 84003, United States
Sandra L. Maxwell Cancer Center
Cedar City, Utah, 84720, United States
Logan Regional Hospital
Logan, Utah, 84321, United States
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
Murray, Utah, 84157, United States
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
Ogden, Utah, 84403, United States
Utah Valley Regional Medical Center - Provo
Provo, Utah, 84604, United States
LDS Hospital
Salt Lake City, Utah, 84143, United States
Dixie Regional Medical Center - East Campus
St. George, Utah, 84770, United States
Island Hospital Cancer Care Center at Island Hospital
Anacortes, Washington, 98221, United States
St. Joseph Cancer Center
Bellingham, Washington, 98225, United States
Olympic Hematology and Oncology
Bremerton, Washington, 98310, United States
Highline Medical Center Cancer Center
Burien, Washington, 98166, United States
Swedish Medical Center - Issaquah Campus
Issaquah, Washington, 98029, United States
Columbia Basin Hematology
Kennewick, Washington, 99336, United States
Skagit Valley Hospital Cancer Care Center
Mount Vernon, Washington, 98274, United States
Harrison Poulsbo Hematology and Onocology
Poulsbo, Washington, 98370, United States
Harborview Medical Center
Seattle, Washington, 98104, United States
Minor and James Medical, PLLC
Seattle, Washington, 98104, United States
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109, United States
Group Health Central Hospital
Seattle, Washington, 98112, United States
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
Seattle, Washington, 98122-4307, United States
Polyclinic First Hill
Seattle, Washington, 98122, United States
University Cancer Center at University of Washington Medical Center
Seattle, Washington, 98195, United States
North Puget Oncology at United General Hospital
Sedro-Woolley, Washington, 98284, United States
Cancer Care Northwest - Spokane South
Spokane, Washington, 99202, United States
Evergreen Hematology and Oncology, PS
Spokane, Washington, 99218, United States
Southwest Washington Medical Center Cancer Center
Vancouver, Washington, 98664, United States
Wenatchee Valley Medical Center
Wenatchee, Washington, 98801-2028, United States
Rocky Mountain Oncology
Casper, Wyoming, 82609, United States
Related Publications (1)
Hershman DL, Unger JM, Hillyer GC, Moseley A, Arnold KB, Dakhil SR, Esparaz BT, Kuan MC, Graham ML 2nd, Lackowski DM, Edenfield WJ, Dayao ZR, Henry NL, Gralow JR, Ramsey SD, Neugut AI. Randomized Trial of Text Messaging to Reduce Early Discontinuation of Adjuvant Aromatase Inhibitor Therapy in Women With Early-Stage Breast Cancer: SWOG S1105. J Clin Oncol. 2020 Jul 1;38(19):2122-2129. doi: 10.1200/JCO.19.02699. Epub 2020 May 5.
PMID: 32369401DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Alfred I. Neugut, MD, PhD
Herbert Irving Comprehensive Cancer Center
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 21, 2012
First Posted
January 24, 2012
Study Start
May 1, 2012
Primary Completion
January 1, 2018
Study Completion
February 1, 2018
Last Updated
March 8, 2018
Record last verified: 2018-03