Impact of Adolescent Vaccine Reminder Notices Sent Via Preferred Method of Communication on HPV Vaccination

NCT05148559 | Active Not Recruiting

• 2 other identifiers: MCL10517U01IP001093
• Study Type: interventional
• Target: 5,451
• Locations: 1 country
• Sites: 1

Brief Summary

Vaccine uptake in the United States is lower in rural areas, especially for HPV vaccine. Reminder/recall has been identified as an effective strategy to increase vaccination rates. This study will assess the impact by rurality of vaccine reminder notices sent via the parent's preferred method of communication on HPV vaccination among 12 year-old patients in a regional healthcare system.

Conditions

Papillomavirus Vaccines

Outcome Measures

Primary Outcomes (1)

• Number of patients that received 1 dose of HPV vaccine during follow-up based on electronic health data

  Receipt of 1 dose of HPV vaccine within 90 days of receipt of reminder (yes/no) will be assessed using vaccination data available from the Marshfield Clinic Health System electronic health record, which includes vaccinations administered outside of MCHS through data exchanges with the Wisconsin Immunization Registry. Specifically patients will be classified as having received 1 dose of HPV vaccine if they have record of receipt of HPV vaccine with a vaccination date during the 90-day follow-up period.

  90 days

Study Arms (2)

Enhanced Reminder

EXPERIMENTAL

Behavioral: Reminder Sent Via Preferred Method of Communication

Standard of Care

OTHER

Behavioral: Reminder Sent Via Mailed Letter

Interventions

Reminder Sent Via Preferred Method of Communication BEHAVIORAL

Parents of 12 year-old patients due for ≥1 adolescent vaccine will receive a vaccine reminder notice every other month via their preferred method of communication (text message, email, mailed letter) until the adolescent receives all recommended vaccines, opts out of reminders, or turns 13.

Enhanced Reminder

Reminder Sent Via Mailed Letter BEHAVIORAL

Parents of 12 year-old patients due for ≥1 adolescent vaccine will receive a mailed vaccine reminder letter every other month until the adolescent receives all recommended vaccines, opts out of reminders, or turns 13.

Standard of Care

Eligibility Criteria

• Age: 12 Years - 12 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Marshfield Clinic Health System patient aged 12 years with at least one preventive visit or two evaluation \& management visits with a Marshfield Clinic Health System provider in the last 36 months
• Due for at least one adolescent vaccine (HPV, MenACWY, Tdap)

You may not qualify if:

• Primary care provider is not affiliated with Marshfield Clinic Health System
• Opted out of Marshfield Clinic Health System vaccine reminder notifications
• Missing or invalid contact information
• Deceased

Sponsors & Collaborators

• Huong Nguyen, PhD: lead
• Centers for Disease Control and Prevention: collaborator

Study Sites (1)

Marshfield Clinic Health System

Marshfield, Wisconsin, 54449, United States

Location

Study Officials

• Huong McLean, PhD

  Marshfield Clinic Research Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Senior Research Scientist

Study Record Dates

• First Submitted: November 16, 2021
• First Posted: December 8, 2021
• Study Start: August 12, 2021
• Primary Completion: November 2, 2022
• Study Completion (Estimated): December 1, 2026
• Last Updated: November 21, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)