Let's K-Talk - HPV Study for Ethnic Koreans

NCT05884697 | Active Not Recruiting

• 1 other identifier: HPV Study for Ethnic Koreans
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to test the feasibility, acceptability, and preliminary efficacy of a storytelling video-based intervention using AI chatbot technology (K-Talk) to promote HPV vaccination behavior among Korean Americans aged 18 to 45. The main questions this study aims to answer are:

• Is the K-Talk intervention feasible for use among Korean Americans aged 18 to 45?
• Is the K-Talk intervention acceptable to the target population?
• What is the preliminary efficacy of the K-Talk intervention in promoting HPV vaccination uptake? Participants will be Korean Americans aged 18 to 45 who are at risk for HPV infection. Participants will be asked to complete a baseline survey and then will be "randomized" into one of four groups: Group 1 (chatbot + storytelling intervention), Group 2 (chatbot only), Group 3 (storytelling only), and Group 4 will be only exposed to written didactic HPV education materials. All groups will receive written didactic HPV education materials. Researchers will compare how Group 1, a combination of AI Chatbot and storytelling intervention is more effective than other intervention groups in promoting HPV vaccination uptake among underserved, hard-to-reach Korean Americans.

Conditions

Human Papillomavirus Viruses; Papillomavirus Vaccines

Keywords

Korean immigrants; HPV Vaccines; Storytelling Intervention; Korean Americans; Artificial Intelligence Chatbot

Outcome Measures

Primary Outcomes (5)

• Number of participants who completed 3 doses of HPV vaccines at 12-months

  Completion of 3 doses of HPV vaccines

  12 months after the baseline

• Number of participants who completed 3 doses of HPV vaccines at 6-months

  Completion of 3 doses of HPV vaccines

  6 months after the baseline

• Number of participants who received at least one dose of HPV vaccine at 3-month

  Participants who received at least one dose of HPV vaccine at 3-month

  3-months after the baseline

• Number of participants who received at least one dose of HPV vaccine at 6-month

  Participants who received at least one dose of HPV vaccine at 6-month

  6-months after the baseline

• Number of participants who received at least one dose of HPV vaccine at 12-month

  Participants who received at least one dose of HPV vaccine at 12-month

  12-months after the baseline

Secondary Outcomes (3)

• Assessment of Knowledge about HPV and HPV Vaccines: A 34-Item Survey (True/False/I don't know)

  at baseline and 3-month follow-up

• Assessing Perceived Risk of HPV and Other STIs: A 17-Item Survey (on a 1-5 Likert scale)

  at baseline and 3-month follow-up

• Assessment of Intention to Receive HPV Vaccine: Two Items Self-Report

  at baseline, 3-month, 6-month, and 12-month follow-up

Study Arms (4)

K-Talk Intervention: Storytelling and AI Chatbot

EXPERIMENTAL

After completing the pre-test survey, participants from all intervention groups will receive the written information. Subsequently, they will be randomly assigned to one of the intervention groups. The K-Talk group will receive a series of weekly storytelling videos, and access to the chatbot via the web-based platform KakaoTalk for 3 months.

Other: K-Talk Intervention (Storytelling and K-Bot); Other: Written Information

Storytelling Intervention

EXPERIMENTAL

After completing the pre-test survey, participants from all intervention groups will receive the written information. Subsequently, they will be randomly assigned to one of the intervention groups. The storytelling intervention group will only be exposed to periodic release of stories via email for 3 months.

Other: Storytelling Intervention; Other: Written Information

K-Bot (AI Chatbot Intervention) Intervention

EXPERIMENTAL

After completing the pre-test survey, participants from all intervention groups will receive the written information. Subsequently, they will be randomly assigned to one of the intervention groups. The K-Bot group will only interact with the chatbot via the web-based platform or KakaoTalk for 3 months.

Other: K-Bot Intervention; Other: Written Information

Written Information

ACTIVE COMPARATOR

This group will only be exposed to written, didactic HPV education materials after the pre-test.

Other: Written Information

Interventions

K-Talk Intervention (Storytelling and K-Bot) OTHER

The K-Talk intervention group receives a combination of a storytelling intervention and an artificial intelligence chatbot (K-Bot) education.

K-Talk Intervention: Storytelling and AI Chatbot

Storytelling Intervention OTHER

The storytelling intervention features 12 authentic stories from young Korean immigrants and Americans. Each video is about 3 minutes long and includes stories from 1st, 1.5, and 2nd generation young Korean individuals, highlighting their perceptions of HPV and HPV vaccines, and their experiences with HPV vaccination.

Storytelling Intervention

K-Bot Intervention OTHER

The K-Bot intervention is a conversational and button-based artificial intelligence Chatbot that is available in both English and Korean.

K-Bot (AI Chatbot Intervention) Intervention

Written Information OTHER

The written information provided includes the Centers for Disease Control and Prevention's (CDC) details on HPV and HPV vaccines.

K-Bot (AI Chatbot Intervention) Intervention; K-Talk Intervention: Storytelling and AI Chatbot; Storytelling Intervention; Written Information

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Identify as a Korean ethnic person
• Reside in the U.S.
• between the ages of 18 and 45
• be able to speak or read English
• not have been vaccinated against HPV
• use a mobile device.

You may not qualify if:

• Participants who do not identify as a Korean ethnic person
• Participants who do not reside in the U.S.
• Participants who are not between the ages of 18 and 45.
• Participants who cannot speak or read English.
• Participants who have been vaccinated against HPV.
• Participants who do not use a mobile device.

Sponsors & Collaborators

• University of Cincinnati: lead

Study Sites (1)

Minjin Kim

Cincinnati, Ohio, 45221-0038, United States

Location

Study Officials

• Minjin Kim, PhD., RN

  UC College of Nursing

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Qualtrics is an online survey software used by researchers. It can randomly assign participants to different groups without revealing the assignments to participants or researchers, blinding them to the assignment. This ensures unbiased treatment and assessment of participants.
• Purpose: PREVENTION
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Participants will be randomized to one of four experimental conditions using a 2x2 factorial design with two factors (Storytelling and Chatbot) and two levels (Yes/On and No/Off). Acceptability and feasibility outcomes include recruitment/retention rates, obtaining photographic documentation, and perceived satisfaction with the intervention.

Study Record Dates

• First Submitted: April 3, 2023
• First Posted: June 1, 2023
• Study Start: May 10, 2023
• Primary Completion: March 31, 2026
• Study Completion (Estimated): July 31, 2026
• Last Updated: August 17, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)