Avoid and Resist Strategies for Weight Management
Evaluating Environmental Control (AVOID) and Inhibitory Control (RESIST) Strategies to Improve Weight Management Outcomes
2 other identifiers
interventional
503
1 country
1
Brief Summary
The proposed randomized controlled trial tests two self-regulatory approaches to improve intentional weight loss and diet quality in individuals with overweight or obesity: (1) an environmental control strategy (AVOID) and (2) an impulse control training strategy (RESIST).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable obesity
Started Jun 2022
Longer than P75 for not_applicable obesity
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 10, 2021
CompletedFirst Posted
Study publicly available on registry
December 3, 2021
CompletedStudy Start
First participant enrolled
June 6, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
February 9, 2027
February 17, 2026
February 1, 2026
4.5 years
November 10, 2021
February 12, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Change in BMI from baseline to 12 months.
BMI will be calculated by aggregating participants' self-reported height in meters and weight in kilograms at baseline, 6- and 12-months.
Baseline, 6-month, 12-month
Secondary Outcomes (1)
Diet quality assessed by 24h-dietary recall
Baseline, 6-month, 12-month
Other Outcomes (14)
Home availability of healthy and unhealthy foods and beverages
Baseline, 6-month, 12-month
Flanker task
Baseline, 6-month, 12-month
Continuous Performance Task Go/No-Go
Baseline, 6-month, 12-month
- +11 more other outcomes
Study Arms (4)
WW Only
ACTIVE COMPARATORWW is commercially-available weight management program focusing on diet, physical activity and mindset skills.
WW + Home modification and grocery delivery (AVOID)
EXPERIMENTALWW + modification of home food environment + online grocery shopping and delivery
WW + Inhibitory control training (RESIST)
EXPERIMENTALWW + daily gamified inhibitory control training
WW + Home food modification and grocery delivery (AVOID) + Inhibitory control training (RESIST)
EXPERIMENTALWW + modification of home food environment + online grocery shopping and delivery + daily gamified inhibitory control training
Interventions
Participants (Arms 2 \& 4) will receive 6 months of coaching (Zoom and/or email/text) to modify their home food environment and alter cues to promote healthy food choices
Participants assigned to RESIST (Arms 3 \& 4) will receive 6 months of coaching (Zoom and/or email/text) and gamified inhibitory control training.
Participants assigned to all arms will receive 6 months of coaching (Zoom and/or email/text) and commercially-available weight management program focusing on diet, physical activity and mindset skills.
Eligibility Criteria
You may qualify if:
- Age 18 years or older
- BMI between 25-45 kg/m2
- Read, write, and speak English with acceptable visual acuity
- Has a household member (≥ 14 years) willing to complete three brief assessments over 12 months\* \*Only applies to individuals who indicate they are cohabitating with at least one eligible household member
- years-old
- Parent consent for children \<18-years-old
- Willingness to complete assessments / measurements
You may not qualify if:
- Currently enrolled in weight loss interventions or undergoing bariatric surgery
- Pregnant women
- Individuals for whom weight loss may be contraindicated (e.g., unstable coronary artery disease, end-stage disease, active cancer treatment, uncontrolled insulin-dependent diabetes, portal hypertension, drug/alcohol abuse)
- Individuals with severe cognitive delays or visual/hearing impairment
- Individuals who are unable or unwilling to complete the study assessments / measurements
- ≤ 14-years-old
- Individuals who are unable or unwilling to complete the study assessments / measurements
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- WW International Inccollaborator
- The University of Tennessee, Knoxvillecollaborator
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)collaborator
- Northeastern Universitycollaborator
- Cedars-Sinai Medical Centerlead
- University of California, Riversidecollaborator
Study Sites (1)
Cedars-Sinai Medical Center
Los Angeles, California, 90069, United States
Related Publications (2)
Sobolev M, Ruiz J, Diniz MA, Raynor H, Foster GD, Seitz AR, Salvy SJ. Preference for behavior change strategies in randomized controlled trials: Evidence from weight management. Contemp Clin Trials. 2025 Sep;156:108031. doi: 10.1016/j.cct.2025.108031. Epub 2025 Jul 28.
PMID: 40738220DERIVEDCaceres NA, Yu Q, Capaldi J, Diniz MA, Raynor H, Foster GD, Seitz AR, Salvy SJ. Evaluating environmental and inhibitory control strategies to improve outcomes in a widely available weight loss program. Contemp Clin Trials. 2022 Aug;119:106844. doi: 10.1016/j.cct.2022.106844. Epub 2022 Jul 5.
PMID: 35798248DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Sarah-Jeanne Salvy, PhD
Cedars-Sinai Medical Center
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor, Department of Medicine
Study Record Dates
First Submitted
November 10, 2021
First Posted
December 3, 2021
Study Start
June 6, 2022
Primary Completion (Estimated)
December 1, 2026
Study Completion (Estimated)
February 9, 2027
Last Updated
February 17, 2026
Record last verified: 2026-02
Data Sharing
- IPD Sharing
- Will not share