Mechanical Power in Pediatric Mechanical Ventilation

NCT05127317 | Completed

• 1 other identifier: 2017-KAEK-02082021
• Study Type: observational
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

Mechanical power is the amount of energy transferred to the respiratory system of patients during each breath period. After overcoming the resistances required for respiration, the remaining energy may end up by damaging the lung parenchyma. Promising studies are showing that this amount of energy, which can be calculated mathematically, can be used as a single indicator instead of the limits used for barotrauma, volu-trauma, or atelecto-trauma in adult patients. However, the MP limit that should not be exceeded in pediatric patients is not yet clear. In this study, we present our MP calculations in pediatric anesthesia

Conditions

Mechanical Ventilation Complication; Aediatric Anesthesia

Keywords

mechanical ventilation; pediatric anesthesia; mechanical power

Outcome Measures

Primary Outcomes (1)

• median mechanical power

  mechanical force applied to the lungs during mechanical ventilation, calculated according to the formula

  Measurements will be taken after half an hour of mechanical ventilation.

Secondary Outcomes (1)

• indexed mechanical power

  Data will be obtained at the beginning of the operation and after half an hour of ventilation

Interventions

Mechanical power DIAGNOSTIC_TEST

In our study, mechanical power (MP) will be calculated during mechanical ventilation in patients who will be operated under general anesthesia. MP will be calculated with the simplified formula applied by Gattinoni et al. MPvcv: RR x Tv x (PIP-\[(Pplat-PEEP)/2\]) x 0.098(2) In pressure-controlled ventilation, the simplified MP formula of Becher et al. well be used. MPpcv: RR x Tv x (ΔPinsp + PEEP) x 0.098 (11) For MP calculated according to the weight of the patients; Indexed MP: MP /kg according to IBW. For the force applied to the lungs in each inspiration; Dynamic power (mJ/min): Vt x RR x \[(Pplato+ tPEEP)/2\]. For the driver power that provides the gas flow; Driving power (mJ/min): Vt x RR x \[ (Pplat - tPEEP) / 2\]. Calculating mechanical energy; Mechanical energy (mJ/kg): 0.098 x (V x kg ) x (PIP - \[(P plateau- PEEP) / 2\]) formulas were used

Eligibility Criteria

• Age: 0 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

All patients under the age of 18 who will undergo laparoscopic lower abdomen surgery under general anesthesia under elective conditions.

You may qualify if:

• \- To undergo laparoscopic lower abdomen surgery under general anesthesia under elective conditions under the age of 18

You may not qualify if:

• \- Patients in both groups weill be excluded if they had uncorrected congenital heart disease, pre-existing lung or airway disease, conditions that may decrease chest wall compliance, chronic respiratory failure requiring long-term MV, and tracheostomy.

Sponsors & Collaborators

• Bozok University: lead

Study Sites (1)

Bozok Univesity Hospital

Yozgat, 66001, Turkey (Türkiye)

Location

Related Publications (2)

• Kneyber MCJ. Driving Pressure and Mechanical Power: The Return of Physiology in Pediatric Mechanical Ventilation. Pediatr Crit Care Med. 2021 Oct 1;22(10):927-929. doi: 10.1097/PCC.0000000000002829. No abstract available.

  PMID: 34605787 RESULT

• Becher T, van der Staay M. Calculation of mechanical power for pressure-controlled ventilation: author's reply. Intensive Care Med. 2019 Oct;45(10):1498-1499. doi: 10.1007/s00134-019-05742-7. Epub 2019 Aug 20. No abstract available.

  PMID: 31432217 RESULT

Study Officials

• Ahmet YUKSEK, asst.prof

  Yozgat Bozok Universitesi

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Asst.Prof.Dr.

Study Record Dates

• First Submitted: November 12, 2021
• First Posted: November 19, 2021
• Study Start: August 10, 2021
• Primary Completion: December 10, 2021
• Study Completion: January 10, 2022
• Last Updated: July 11, 2022

Record last verified: 2022-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)