Characterization of Reverse Triggering and Other Asynchronies in COVID-19 Patients Under Invasive Mechanical Ventilation

NCT04448782 | Completed

• 1 other identifier: RT COVID-19
• Study Type: observational
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

Prospective observational trial in patients admitted to ICU diagnosed with COVID-19 requiring invasive mechanical ventilation. Characterization of Reverse Triggering asynchrony during the first 5 days of invasive mechanical ventilation and other asynchronies, and its correlation with different outcomes.

Conditions

Mechanical Ventilation Complication

Outcome Measures

Primary Outcomes (1)

• Incidence and pattern of presentation of Reverse triggering in COVID-19 patients under invasive mechanical ventilation

  To analyze the incidence of Reverse Triggering in the initial phases of invasive mechanical ventilation in COVID-19 patients

  during the 5 first days of invasive mechanical ventilation

Secondary Outcomes (4)

• Incidence of Reverse Triggering related to the level of sedation in COVID-19 patients under invasive mechanical ventilation

  From the day of mechanical ventilation initation up to 5 days or the last day of mechanical ventilation

• Reverse triggering and secondary asynchronies in COVID-19 patients under invasive mechanical ventilation

  From the day of mechanical ventilation initiation up to 5 days

• Incidence and pattern of presentation of asynchronies in COVID-19 patients under invasive mechanical ventilation

  Each day from the day of mechanical ventilation initiation until the day of mechanical ventilation withdrawal or up to 28 days

• Influence of asynchronies in different outcomes in in COVID-19 patients under invasive mechanical ventilation

  Each day from the day of mechanical ventilation initiation until the end of invasive mechanical ventilation, ICU discharge and hospital discharge or up to 28 days

Interventions

Asynchronies detection DIAGNOSTIC_TEST

Asycnhronies detection

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients admitted to the ICU under invasive mechanical ventilation with ARDS secondary to COVID-19

You may qualify if:

• Patients under invasive mechanical ventilation more than 24 hours and with a minimum of 48 hours of respiratory signals registered from the ventilator
• Diagnosis of COVID-19

You may not qualify if:

• less than 48 hours of data,
• age \< 18 years
• admitted from other centers under invasive mechanical ventilation.

Sponsors & Collaborators

• Corporacion Parc Tauli: lead

Study Sites (1)

Candelaria de Haro

Sabadell, Barcelona, 08208, Spain

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: June 17, 2020
• First Posted: June 26, 2020
• Study Start: March 9, 2020
• Primary Completion: June 30, 2020
• Study Completion: June 30, 2020
• Last Updated: July 14, 2020

Record last verified: 2020-07

Locations

ES (1)