Ganglion Cell Thickness in Enuresis Nocturna

NCT05126732 | Unknown

• 1 other identifier: 341/321
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The precise role of the intrinsic circadian regulatory mechanism behind the pathogenesis of enuresis is not fully understood, but in theory, circadian rhythm irregularity may be the primary pathogenic mechanism not only for urinary outflow mechanisms but also for nocturnal bladder function. The proximity between SCN centers that control AVP release, sleep/arousal, voiding, and baroreregulation may provide the basis for circadian rhythm disturbance in one or more of these biological functions. Ganglion cells containing melanopsin pigment in the retina transmit the information they receive from the outside world about the light-dark state to the SCN via the retinohypothalamic pathway. Peripapillary retinal nerve fiber layer (RNFL) thickness, optic nerve head and macula are examined most frequently for the diagnosis of glaucoma and the detection of progression with optical coherence tomography (OCT). If differences in ganglion cell thickness can be detected using OCT in these children, a new avenue in Enuresis Nocturna may be opened.

Conditions

Enuresis, Nocturnal; Ganglion; Circadian Rhythm Disorders

Keywords

enuresis; optical coherence tomography

Outcome Measures

Primary Outcomes (1)

• Difference in ganglion cell thickness in enuretic children

  Normal values in RNFL measurements on OCT 75 (lowest)-107.2 (highest)

  Baseline

Eligibility Criteria

• Age: 5 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Pediatric patients aged 5-18 years, with enuresis, without any eye disease

You may qualify if:

• be between the ages of 5-18
• have enuresis

You may not qualify if:

• have any eye conditions

Sponsors & Collaborators

• Izmir Bakircay University: lead

Study Sites (1)

Bakircay University

Izmir, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Nocturnal Enuresis; Ganglion Cysts; Chronobiology Disorders; Enuresis

Condition Hierarchy (Ancestors)

Urination Disorders; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Behavioral Symptoms; Behavior; Elimination Disorders; Mental Disorders; Cysts; Neoplasms; Mucinoses; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Nervous System Diseases

Central Study Contacts

Yasar ISSI

CONTACT

00905321704131; yasarissi@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Asistant Professor

Study Record Dates

• First Submitted: October 28, 2021
• First Posted: November 19, 2021
• Study Start: January 1, 2022
• Primary Completion: April 1, 2022
• Study Completion: July 1, 2022
• Last Updated: November 19, 2021

Record last verified: 2021-11

Locations

TU (1)