NCT05114356

Brief Summary

The registry has been designed as a prospective, observational program for patients undergoing anterior cervical discectomy and fusion (ACDF) procedures treated with TIDAL cervical interbody fusion device. The ultimate goal of the study is to aid in the development of treatment pathways and improved patient care. All patients who agree to participate in the registry will sign an informed consent form and subsequently be treated by their surgeon with the device in either an inpatient or outpatient facility.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
73

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Nov 2021

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 20, 2021

Completed
19 days until next milestone

Study Start

First participant enrolled

November 8, 2021

Completed
2 days until next milestone

First Posted

Study publicly available on registry

November 10, 2021

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 22, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 22, 2024

Completed
Last Updated

July 3, 2024

Status Verified

July 1, 2024

Enrollment Period

2.5 years

First QC Date

October 20, 2021

Last Update Submit

July 1, 2024

Conditions

Outcome Measures

Primary Outcomes (2)

  • Change in Oswestry Disability Index (ODI)/Neck Disability Index (NDI) Score Range 0-50 at 1 year post-operative from a pre-operative baseline

    ODI/NDI Score Range: 0-50 0-4 No disability 5-14 Mild disability 15-24 Moderate disability 25-34 Severe disability \>34 Complete disability

    1 year

  • Change in VAS Pain at 1 year post-operative from a pre-operative baseline

    VAS PAIN SEVERITY SCALE ranges from 0-10. A score of zero (0) means 'no pain' and a ten (10) means 'worst imaginable pain'

    1 year

Secondary Outcomes (2)

  • Improvement in patient reported short-form 36 (SF36) scores at 1 year post-operative from a pre-operative baseline

    1 year

  • Rate of Successful Fusion Based on Radiological Assessment at 1 Year Post-op

    1 year

Study Arms (1)

Study group

Patients being treated for degenerative disc disease

Device: TIDAL Cervical Interbody Fusion implant

Interventions

Cervical interbody fusion device

Study group

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients diagnosed with degenerative disc disease of the cervical spine, and being surgically treated for degenerative cervical disc disease using a 3D printed titanium interbody cage

You may qualify if:

  • Neck and arm pain for a minimum of 6 weeks before surgery that is recalcitrant to nonoperative treatment modalities, such as physical therapy, reduced activities, and anti-inflammatory medications.
  • Radiographic evidence of cervical disc disease that is documented on dynamic radiographs and magnetic resonance imaging (MRI).

You may not qualify if:

  • Medical condition that required medication, such as steroids or nonsteroidal anti-inflammatory medications, that could interfere with fusion.
  • There are no restrictions on sex or ethnicity.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Orthopaedic Institute of Western Kentucky

Paducah, Kentucky, 42001, United States

Location

MeSH Terms

Conditions

Intervertebral Disc Degeneration

Condition Hierarchy (Ancestors)

Spinal DiseasesBone DiseasesMusculoskeletal Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
12 Months
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 20, 2021

First Posted

November 10, 2021

Study Start

November 8, 2021

Primary Completion

May 22, 2024

Study Completion

May 22, 2024

Last Updated

July 3, 2024

Record last verified: 2024-07

Locations