Relationship Between Adipose Tissue Distribution and Arterial Stiffness in HFpEF

NCT05095688 | Unknown

• 1 other identifier: 2020-09-19
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Heart failure with preserved ejection fraction (HFpEF) was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between lipids distribution and arterial stiffness in HFpEF patients.

Conditions

Heart Failure With Preserved Ejection Fraction; Arterial Stiffness; Lipid Disorder

Outcome Measures

Primary Outcomes (2)

• Arterial stiffness

  The baPWV(cm/s) of HFpEF patients

  1 day after admission

• adipose tissue distribution

  The visceral fat area(cm\^2) in HFpEF patients

  1 day after admission

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Heart failure patients with preserved ejection fraction (HFpEF)

You may qualify if:

• Adult aged \>=18years old;
• Diagnosed with HFpEF.
• Diagnostic criteria including:
• left ventricular ejection fraction ≥50%；
• with the symptoms and/or signs of heart failure；
• BNP≥35 pg/mL and/or NTproBNP≥125 pg/mL；
• at least one additional criterion: relevant structural heart disease(LVH and/or LAE) or diastolic dysfunction

You may not qualify if:

• LVEF less than 45% at any time;
• Severe liver failure; 3/Other causes of shortness of breath, such as severe pulmonary disease or severe chronic obstructive pulmonary disease;
• Primary pulmonary hypertension; 5.Severe valvular disease of the left heart; 6.Chronically bedridden or incapacitated; 7.Age \<18 years old.

Sponsors & Collaborators

• Chongqing Medical University: lead

Study Sites (1)

The First Affiliated Hospital of Chongqing Medical University

Chongqing, 400000, China

RECRUITING

MeSH Terms

Conditions

Lipid Metabolism Disorders

Condition Hierarchy (Ancestors)

Metabolic Diseases; Nutritional and Metabolic Diseases

Central Study Contacts

Dongying Zhang, doctor

CONTACT

+8613608398395; zdy.chris@qq.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: October 11, 2020
• First Posted: October 27, 2021
• Study Start: September 21, 2020
• Primary Completion: December 31, 2021
• Study Completion: December 31, 2022
• Last Updated: October 27, 2021

Record last verified: 2021-10

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)