The Relationship Between Pericardial Fat Thickness and Arterial Stiffness in HFpEF Patients

NCT04594499 | Unknown

• 1 other identifier: 2020-10
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Heart failure with preserved ejection fraction (HFpEF) was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between blood pressure and arterial stiffness in HFpEF patients with different levels of obesity.

Conditions

Heart Failure With Preserved Ejection Fraction

Keywords

epicardial fat tissue, arterial stiffness

Outcome Measures

Primary Outcomes (2)

• Arterial stiffness

  The arterial stiffness of HFpEF patients, for example brachial ankle pulse wave velocity, ardioankle vascular index and so on.

  On admission

• Epicardial Fat Tissue

  Epicardial Fat Tissue by cardiac color Doppler ultrasound

  On admission

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Heart failure patients with preserved ejection fraction (HFpEF)

You may qualify if:

• Adult aged \>=18years old;
• Diagnosed with HFpEF.
• Diagnostic criteria including:
• left ventricular ejection fraction ≥50%；
• with the symptoms and/or signs of heart failure；
• BNP≥35 pg/mL and/or NTproBNP≥125 pg/mL；
• at least one additional criterion: relevant structural heart disease(LVH and/or LAE) or diastolic dysfunction

You may not qualify if:

• LVEF less than 45% at any time;
• Severe liver failure;
• Primary pulmonary hypertension;
• Age \<18 years old.

Sponsors & Collaborators

• Chongqing Medical University: lead

Study Sites (1)

The First Affiliated Hospital of Chongqing Medical University

Chongqing, China

RECRUITING

Study Officials

• Dongying Zhang, doctor

  First Affiliated Hospital of Chongqing Medical University

  STUDY DIRECTOR

Central Study Contacts

Dongying Zhang, doctor

CONTACT

+8613608398395; zdy.chris@qq.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: October 15, 2020
• First Posted: October 20, 2020
• Study Start: September 1, 2020
• Primary Completion: December 1, 2022
• Study Completion: December 20, 2022
• Last Updated: October 20, 2020

Record last verified: 2020-10

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)