A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)
VICTOR
A Pivotal Phase 3 Randomized, Placebo-controlled Clinical Study to Evaluate the Efficacy and Safety of the sGC Stimulator Vericiguat/MK-1242 in Adults With Chronic Heart Failure With Reduced Ejection Fraction
5 other identifiers
interventional
6,106
35 countries
514
Brief Summary
The purpose of this study is to evaluate the efficacy and safety of vericiguat in participants with chronic heart failure with reduced ejection fraction (HFrEF), specifically those with symptomatic chronic HFrEF who have not had a recent hospitalization for heart failure or need for outpatient intravenous (IV) diuretics. The primary hypothesis is that vericiguat is superior to placebo in reducing the risk of cardiovascular death or heart failure hospitalization.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Nov 2021
Typical duration for phase_3
514 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 18, 2021
CompletedFirst Posted
Study publicly available on registry
October 26, 2021
CompletedStudy Start
First participant enrolled
November 2, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 20, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
February 5, 2025
CompletedResults Posted
Study results publicly available
December 19, 2025
CompletedDecember 19, 2025
December 1, 2025
3.1 years
October 18, 2021
November 4, 2025
December 4, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Time to First Occurrence of Composite Endpoint of Cardiovascular (CV) Death or Heart Failure (HF) Hospitalization: Participants With an Event Per 100 Patient-Years
The time to first occurrence of the composite endpoint of CV death or HF hospitalization was defined as the time from randomization to the first event of CV death or HF hospitalization. Randomized participants without a HF hospitalization or CV death event at the time of analysis were censored at the last available information, when the protocol pre-specified number of total CV death events was achieved (primary completion analysis data cutoff), or the date of their non-CV death, whichever occurred first. Events were confirmed by a clinical events committee (CEC). Protocol-specified final analyses are reported here with a primary completion data cutoff. Time-to-event methodology was used to evaluate the results and the number of participants with a CV death or HF hospitalization event per 100 patient-years at risk is presented.
Up to approximately 36 months (from randomization to the primary completion data cutoff)
Secondary Outcomes (11)
Time to CV Death: Participants With an Event Per 100 Patient-Years
Up to approximately 36 months (from randomization to the primary completion data cutoff)
Time to First Occurrence of HF Hospitalization: Participants With an Event Per 100 Patient-Years
Up to approximately 36 months (from randomization to the primary completion data cutoff)
Time to Total HF Hospitalizations (Including First and Recurrent Events): Total Events Per 100 Patient-Years
Up to approximately 36 months (from randomization to the primary completion data cutoff)
Time to First Occurrence of Composite Endpoint of All-Cause Mortality or HF Hospitalization: Participants With an Event Per 100 Patient-Years
Up to approximately 36 months (from randomization to the primary completion data cutoff)
Time to All-Cause Mortality: Participants With an Event Per 100 Patient-Years
Up to approximately 36 months (from randomization to the primary completion data cutoff)
- +6 more secondary outcomes
Study Arms (2)
Vericiguat
EXPERIMENTALParticipants receive a starting dose of 2.5 mg of vericiguat taken orally once daily. The vericiguat dose will be titrated to 5 mg and to 10 mg.
Placebo
PLACEBO COMPARATORParticipants receive a starting matching placebo to vericiguat dose of 2.5 mg taken orally once daily. The matching placebo dose will be sham titrated to 5 mg and to 10 mg.
Interventions
Eligibility Criteria
You may qualify if:
- History of chronic HF \[New York Heart Association (NYHA) Class II to IV\] on guideline-directed medical therapy for heart failure (GDMT) with no HF hospitalization within 6 months or outpatient IV diuretic use within 3 months before randomization.
- Left ventricular ejection fraction (LVEF) of ≤40%, assessed within 12 months before randomization by any imaging method.
- Elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels.
- A female participant is eligible to participate if she is not pregnant or breastfeeding, is not a woman of childbearing potential (WOCBP), or is a WOCBP and agrees to follow contraceptive guidance during the study intervention period and for at least 1 month after the last dose of study intervention.
You may not qualify if:
- Has SBP \<100 mm Hg or symptomatic hypotension.
- Awaiting heart transplantation, is receiving continuous IV infusion of an inotrope, or has or anticipates receiving an implanted ventricular assist device.
- Amyloidosis or sarcoidosis.
- Primary valvular heart disease requiring surgical procedure or intervention or has undergone a valvular surgical procedure or intervention within 3 months before randomization.
- Hypertrophic cardiomyopathy.
- Acute myocarditis or Takotsubo cardiomyopathy.
- History of heart transplant.
- Tachycardia-induced cardiomyopathy and/or uncontrolled tachyarrhythmia.
- Acute coronary syndrome, or undergone coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) within 3 months before randomization.
- History of symptomatic carotid stenosis, transient ischemic attack (TIA), or stroke within 3 months before randomization.
- Malignancy or other noncardiac condition limiting life expectancy to \<3 years.
- Requires continuous home oxygen for severe pulmonary disease.
- Interstitial lung disease.
- Discontinuation or dose modification of GDMT or vericiguat within 4 weeks before randomization.
- Recent history (within the last year) of drug or alcohol abuse or dependence.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (519)
Advanced Cardiovascular - Alexander City ( Site 0038)
Alexander City, Alabama, 35010, United States
University of Alabama at Birmingham - School of Medicine-Cardiology ( Site 0153)
Birmingham, Alabama, 35294, United States
Heart Center Research, LLC ( Site 0156)
Huntsville, Alabama, 35801, United States
Mercy Gilbert Medical Center-Dignity Health Cardiology ( Site 0075)
Gilbert, Arizona, 85297, United States
Valley Clinical Trials, Inc. ( Site 0085)
Covina, California, 91723, United States
VA West Los Angeles Medical Center-Cardiology ( Site 0149)
Los Angeles, California, 90073, United States
Valley Clinical Trials Inc ( Site 0006)
Northridge, California, 91325, United States
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 0010)
Torrance, California, 90502, United States
Blue Coast Research Center ( Site 0053)
Vista, California, 92081, United States
Excel Medical Clinical Trials ( Site 0008)
Boca Raton, Florida, 33434, United States
Universal Axon Clinical Research, LLC ( Site 0022)
Doral, Florida, 33166, United States
Holy Cross Hospital ( Site 0100)
Fort Lauderdale, Florida, 33308, United States
Indago Research and Health Center Inc ( Site 0011)
Hialeah, Florida, 33012, United States
South Florida Research Solutions ( Site 0058)
Hollywood, Florida, 33021, United States
University of Florida - Jacksonville ( Site 0169)
Jacksonville, Florida, 32209, United States
East Coast Institute for Research, LLC ( Site 0047)
Jacksonville, Florida, 32216, United States
Cardiovascular Research Center of South Florida ( Site 0074)
Miami, Florida, 33173, United States
ProLive Medical Research ( Site 0032)
Miami, Florida, 33175, United States
Peace River Cardiovascular Center ( Site 0088)
Port Charlotte, Florida, 33952, United States
BAYCARE MEDICAL GROUP ( Site 0099)
Safety Harbor, Florida, 34695, United States
East Coast Institute for Research - St. Augustine ( Site 0016)
Saint Augustine, Florida, 32086, United States
Cardiovascular Center of Sarasota ( Site 0154)
Sarasota, Florida, 34239, United States
Emory University School of Medicine ( Site 0123)
Atlanta, Georgia, 30322, United States
IACT Health ( Site 0106)
Columbus, Georgia, 31904, United States
NSC Research ( Site 0068)
Johns Creek, Georgia, 30024, United States
Georgia Arrhythmia Consultants and Research Institute ( Site 0042)
Macon, Georgia, 31201, United States
Cardiovascular Consultants of South Georgia, LLC ( Site 0137)
Thomasville, Georgia, 31792, United States
Mount Sinai Hospital ( Site 0050)
Chicago, Illinois, 60608, United States
Chicago Medical Research ( Site 0086)
Hazel Crest, Illinois, 60429, United States
OSF Healthcare Cardiovascular Institute ( Site 0122)
Peoria, Illinois, 61614, United States
Methodist Medical Center of Illinois ( Site 0098)
Peoria, Illinois, 61636, United States
Franciscan Physician Network - Indiana Heart Physicians ( Site 0087)
Indianapolis, Indiana, 46237, United States
The Heart Center of Lake County Research Institute-Research ( Site 0147)
Merrillville, Indiana, 46410, United States
Cardiovascular Research of Northwest Indiana ( Site 0036)
Munster, Indiana, 46321, United States
Reid Physician Associates ( Site 0054)
Richmond, Indiana, 47374, United States
University of Iowa ( Site 0005)
Iowa City, Iowa, 52242, United States
Alliance for Multispecialty Research, LLC ( Site 0143)
Wichita, Kansas, 67207, United States
Norton Healthcare-Norton Heart Specialist ( Site 0062)
Louisville, Kentucky, 40205, United States
Cambridge Medical Trials ( Site 0041)
Alexandria, Louisiana, 71301, United States
Louisiana Heart Center - Hammond ( Site 0004)
Hammond, Louisiana, 70403, United States
The Heart Clinic - Hammond ( Site 0155)
Hammond, Louisiana, 70403, United States
Cardiovascular Institute of the South ( Site 0072)
Houma, Louisiana, 70360, United States
Cardiovascular Institute of the South, 3 ( Site 0096)
Lafayette, Louisiana, 70503, United States
IMA Clinical Research ( Site 0112)
Monroe, Louisiana, 71201, United States
Cardiovascular Institute of the South ( Site 0081)
Opelousas, Louisiana, 70570, United States
Maryland Cardiovascular Specialists ( Site 0056)
Baltimore, Maryland, 21229, United States
Capitol Cardiology Associates - Lanham Office-Maryland Research Centers ( Site 0167)
Lanham, Maryland, 20706, United States
Ascension Providence Hospital ( Site 0094)
Southfield, Michigan, 48075, United States
Phillips Medical Services ( Site 0070)
Jackson, Mississippi, 39209, United States
The University of Mississippi Medical Center-Cardiovascular ( Site 0073)
Jackson, Mississippi, 39216, United States
University of Missouri Hospital ( Site 0163)
Columbia, Missouri, 65212, United States
Washington University-Department of Medicine ( Site 0044)
St Louis, Missouri, 63110, United States
St. Louis Heart and Vascular, P.C.-Clinical Trials Unit ( Site 0029)
St Louis, Missouri, 63136, United States
Logan Health Research ( Site 0017)
Kalispell, Montana, 59901, United States
Renown Regional Medical Center-Renown Institute for Heart and Vascular Health ( Site 0168)
Reno, Nevada, 89502, United States
Amici Clinical Research LLC-Research ( Site 0037)
Raritan, New Jersey, 08869, United States
The Valley Hospital ( Site 0035)
Ridgewood, New Jersey, 07450, United States
Cardiovascular Associates of the Delaware Valley ( Site 0097)
Washington Township, New Jersey, 08080, United States
Erie County Medical Center ( Site 0160)
Buffalo, New York, 14215, United States
New York Presbyterian Medical Group Hudson Valley Cardiology ( Site 0127)
Cortlandt Manor, New York, 10567, United States
Icahn School of Medicine at Mount Sinai ( Site 0161)
New York, New York, 10029-5674, United States
CHEAR Center LLC ( Site 0009)
The Bronx, New York, 10455, United States
Southeastern Cardiology and Cardiovascular-Duke HC CRU - Lumberton ( Site 0134)
Lumberton, North Carolina, 28358, United States
Accellacare - Wilmington ( Site 0090)
Wilmington, North Carolina, 28401, United States
Aultman Hospital-Cardiology Clinical Trials ( Site 0064)
Canton, Ohio, 44710, United States
University of Cincinnati Medical Center-Cardiology ( Site 0071)
Cincinnati, Ohio, 45219, United States
ProMedica Toledo Hospital-ProMedica Heart Failure Clinic ( Site 0061)
Toledo, Ohio, 43606, United States
Doylestown Hospital-Cardiology ( Site 0030)
Doylestown, Pennsylvania, 18901, United States
Accellacare - Charleston ( Site 0141)
Charleston, South Carolina, 29464, United States
Apex Research Foundation ( Site 0001)
Jackson, Tennessee, 38301, United States
Vanderbilt University Medical Center-Vanderbilt Heart and Vascular Institue ( Site 0060)
Nashville, Tennessee, 37232, United States
Dallas VA Medical Center ( Site 0084)
Dallas, Texas, 75216, United States
Southwest Family Medicine Associates ( Site 0131)
Dallas, Texas, 75235, United States
Medresearch Inc ( Site 0043)
El Paso, Texas, 79935, United States
West Houston Area Clinical Trial Consultants ( Site 0014)
Houston, Texas, 77094, United States
South Texas Cardiovascular Consultants, PLLC-Research ( Site 0024)
Kerrville, Texas, 78028, United States
South Texas Cardiovascular Consultants, PLLC-Research ( Site 0020)
San Antonio, Texas, 78201, United States
Tyler Cardiovascular Consultants ( Site 0039)
Tyler, Texas, 75701, United States
INOVA Fairfax Medical Campus ( Site 0136)
Falls Church, Virginia, 22042, United States
Carient Heart & Vascular - Manassas ( Site 0059)
Manassas, Virginia, 20109, United States
Sentara Norfolk General Hospital ( Site 0114)
Norfolk, Virginia, 23507, United States
Dominion Medical Associates, Inc. ( Site 0089)
Richmond, Virginia, 23219, United States
Pulse Heart Institute - Puyallup ( Site 0119)
Puyallup, Washington, 98372, United States
MultiCare Health System-MultiCare Cardiology - Inland Northwest ( Site 0102)
Spokane, Washington, 99204, United States
CEDIC ( Site 4363)
CABA, Buenos Aires, C1060ABN, Argentina
Centro de Investigaciones Metabólicas (CINME)-Cardiology ( Site 4352)
Ciudad Autónoma de Buenos Aires, Buenos Aires, C1027AAP, Argentina
DIM Clínica Privada ( Site 4359)
Ramos Mejía, Buenos Aires, B1704ETD, Argentina
Instituto de Investigaciones Clinicas Zarate ( Site 4360)
Zárate, Buenos Aires, B2800DGH, Argentina
Centro Médico Viamonte-Clinical Research ( Site 4361)
Buenos Aires, Buenos Aires F.D., C1120AAC, Argentina
Fundacion Estudios Clinicos ( Site 4356)
Rosario, Santa Fe Province, S2000DEJ, Argentina
Centro de Investigaciones Clinicas del Litoral ( Site 4354)
Santa Fe, 3000, Argentina
Royal Brisbane and Women's Hospital-Cardiology Research ( Site 0453)
Brisbane, Queensland, 4029, Australia
The Prince Charles Hospital-Cardiology Research Centre ( Site 0451)
Brisbane, Queensland, 4032, Australia
Core Research Group ( Site 0452)
Brisbane, Queensland, 4064, Australia
Royal Adelaide Hospital-Cardiology ( Site 0456)
Adelaide, South Australia, 5000, Australia
Flinders Medical Centre-Cardiology Research ( Site 0455)
Bedford Park, South Australia, 5042, Australia
St. John of God Subiaco Hospital ( Site 0457)
Subiaco, Western Australia, 6008, Australia
Medizinische Universität Graz-Department of Cardiology ( Site 0351)
Graz, Styria, 8036, Austria
Krankenhaus St. Josef Braunau ( Site 0354)
Braunau am Inn, Upper Austria, 5280, Austria
Imed19-privat ( Site 0353)
Vienna, Vienna, A-1190, Austria
Uniklinikum Salzburg-Universitätsklinik für Innere Medizin II, Kardiologie, Internistische Intensiv
Salzburg, 5020, Austria
Klinik Floridsdorf-Karl Landsteiner Institute for Cardiovascular and Critical Care Research c/o Dep
Vienna, 1210, Austria
Hospital de Messejana Dr Carlos Alberto Studart Gomes ( Site 0560)
Fortaleza, Ceará, 60864-190, Brazil
Universidade Federal de Goias-Serviço de Cardiologia ( Site 0553)
Goiânia, Goiás, 74605-020, Brazil
PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR ( Site 0555)
Curitiba, Paraná, Brazil
Hospital Mae de Deus ( Site 0564)
Porto Alegre, Rio Grande do Sul, 90880-480, Brazil
Centro de Pesquisa Clinica do Coracao ( Site 0561)
Acaraju, Sergipe, 49055-530, Brazil
Instituto de Pesquisa clinica de Campinas ( Site 0551)
Campinas, São Paulo, 13060-080, Brazil
CAPED Centro Avancado Pesquisa e Diagnostica ( Site 0552)
Ribeirão Preto, São Paulo, 14026-900, Brazil
Hospital de Clínicas de Ribeirão Preto ( Site 0559)
Ribeirão Preto, São Paulo, 14048900, Brazil
Hospital Pro-Cardiaco ( Site 0556)
Rio de Janeiro, 22280-003, Brazil
Incor - Instituto do Coracao ( Site 0557)
São Paulo, 05403-900, Brazil
Heritage Medical Research Clinic ( Site 0679)
Calgary, Alberta, T2N 4Z6, Canada
University Of Alberta Hospital ( Site 0669)
Edmonton, Alberta, T6G 2B7, Canada
Victoria Heart Institute Foundation ( Site 0680)
Victoria, British Columbia, V8R 1B2, Canada
St. Boniface General Hospital ( Site 0667)
Winnipeg, Manitoba, R2H 2A6, Canada
G A Research Associates ( Site 0652)
Moncton, New Brunswick, E1G 1A7, Canada
NSHA-QEII Health Sciences Centre-Dickson Bldg-Cardiology ( Site 0664)
Halifax, Nova Scotia, B3H 3A7, Canada
Cambridge Cardiac Care Centre ( Site 0658)
Cambridge, Ontario, N1R 6V6, Canada
PACE Cardiology ( Site 0675)
Newmarket, Ontario, L3Y 2P6, Canada
North York Diagnostic and Cardiac Centre ( Site 0682)
North York, Ontario, M6B 3H7, Canada
Oakville Cardiovascular Research LP ( Site 0657)
Oakville, Ontario, L6K 3W7, Canada
Private Practice - Dr. James Cha ( Site 0655)
Oshawa, Ontario, L1J 2K1, Canada
Kawartha Cardiology Clinical Trials ( Site 0654)
Peterborough, Ontario, K9J 0B2, Canada
Corcare-Corcare Cardiovascular Research ( Site 0660)
Toronto, Ontario, M1B 5N1, Canada
Medicus MFC Research Clinic ( Site 0676)
Toronto, Ontario, M4P 1E4, Canada
Hôpital de la Cité-de-la-Santé ( Site 0673)
Laval, Quebec, H7M 3L9, Canada
Institut de Cardiologie de Montreal ( Site 0661)
Montreal, Quebec, H1T 1C8, Canada
Montreal General Hospital ( Site 0653)
Montreal, Quebec, H3G 1A4, Canada
Unité de Recherche Clinique du CISSS des Laurentides ( Site 0668)
Saint-Jérôme, Quebec, J7Z 2V4, Canada
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer
Sherbrooke, Quebec, J1H 5N4, Canada
Hopital Pierre-Le Gardeur ( Site 0674)
Terrebonne, Quebec, J6V 2H2, Canada
Diex Recherche Trois-Rivieres ( Site 0677)
Trois-Rivières, Quebec, G9A 4P3, Canada
IC La Serena Research ( Site 0769)
La Serena, Coquimbo Region, 1720430, Chile
Clinica Alemana Osorno ( Site 0768)
Osorno, Los Lagos Region, 5311089, Chile
Clinical Research Chile SpA ( Site 0761)
Valdivia, Los Ríos Region, 5110683, Chile
Enroll SpA ( Site 0755)
Santiago, Region M. de Santiago, 7500587, Chile
Clinica Dermacross ( Site 0760)
Santiago, Region M. de Santiago, 7640881, Chile
Espacio Eme ( Site 0762)
Santiago, Region M. de Santiago, 7770086, Chile
Hospital y CRS El Pino ( Site 0763)
Santiago, Region M. de Santiago, 8053095, Chile
Universidad de Chile - Hospital Clínico Universidad de Chile ( Site 0754)
Santiago, Region M. de Santiago, 8330111, Chile
Clínica Ensenada ( Site 0753)
Santiago, Region M. de Santiago, 8380465, Chile
Cardio Sur ( Site 0756)
Santiago, Region M. de Santiago, 8910259, Chile
Centro De Estudios Cardiologicos Y De Medicina Interna ( Site 0752)
Temuco, Región de la Araucanía, 4780000, Chile
ONCOCENTRO APYS ( Site 0770)
Viña del Mar, Región de Valparaíso, 2520598, Chile
Anhui Provincil Hospital South District ( Site 0920)
Hefei, Anhui, 230036, China
Beijing Anzhen Hospital, Capital Medical University-Cardiovascular ( Site 0856)
Beijing, Beijing Municipality, 100029, China
Aero Space Center Hospital ( Site 0918)
Beijing, Beijing Municipality, 100049, China
Beijing Friendship Hospital-Cardology ( Site 0865)
Beijing, Beijing Municipality, 100050, China
Beijing Tsinghua Changgung Hospital ( Site 0911)
Beijing, Beijing Municipality, 102218, China
The Second Affiliated Hospital Chongqing Medical University-Department of Cardiology ( Site 0908)
Chongqing, Chongqing Municipality, 400010, China
Chongqing Three Gorges Central Hospital ( Site 0913)
Wanzhou, Chongqing Municipality, 404199, China
Lanzhou university second hospital-Lanzhou university second hospital ( Site 0863)
Lanzhou, Gansu, 730030, China
The First People's Hospital of Foshan ( Site 0898)
Foshan, Guangdong, 528041, China
Guangdong Provincial People's Hospital-Cardiology ( Site 0852)
Guangzhou, Guangdong, 510080, China
Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Cardiology ( Site 0868)
Guangzhou, Guangdong, 510120, China
The First Affiliated Hospital of Jinan University ( Site 0897)
Guangzhou, Guangdong, 510630, China
The University of Hong Kong - Shenzhen Hospital-Cardiovascular department ( Site 0895)
Shenzhen, Guangdong, 518053, China
Hainan General Hospital ( Site 0894)
Haikou, Hainan, 570311, China
The First Hospital of Harbin Medical University-Cardiology ( Site 0903)
Harbin, Heilongjiang, 150001, China
Wuhan Union Hospital ( Site 0919)
Wuhan, Hubei, 430022, China
Changsha Central Hospital ( Site 0854)
Changsha, Hunan, 410004, China
Hunan Provincial People's Hospital ( Site 0857)
Changsha, Hunan, 410005, China
Xiangya Hospital Central South University-Cardiological Department ( Site 0899)
Changsha, Hunan, 410008, China
The Third Xiangya Hospital of Central South University-Cardiology ( Site 0860)
Changsha, Hunan, 410013, China
BAO TOU CENTRAL HOSPITAL ( Site 0866)
Baotou, Inner Mongolia, 014040, China
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Cardiolggy
Nanjing, Jiangsu, 210000, China
The Second Affiliated Hospital of Nanjing Medical University-Cardiology ( Site 0900)
Nanjing, Jiangsu, 210011, China
Wuxi No.2 People's Hospital-Cardiology Department ( Site 0877)
Wuxi, Jiangsu, 214002, China
Wuxi People's Hospital-Cardiovascular Department ( Site 0870)
Wuxi, Jiangsu, 214023, China
The Affiliated Hospital of Xuzhou Medical College ( Site 0910)
Xuzhou, Jiangsu, 221006, China
Northern Jiangsu People's Hospital ( Site 0861)
Yangzhou, Jiangsu, 225001, China
Affiliated Hospital of Jiangsu University-Cardiology Department ( Site 0917)
Zhenjiang, Jiangsu, 212001, China
The Second Affiliated Hospital of Nanchang University-Cardiology ( Site 0912)
Nanchang, Jiangxi, 330006, China
China-Japan Union Hospital-department of cardiology ( Site 0916)
Changchun, Jilin, 130033, China
Siping Central People's Hospital-Cardiovascular Department ( Site 0915)
Siping, Jilin, 136000, China
The People's Hospital of Liaoning Province ( Site 0859)
Shenyang, Liaoning, 110016, China
The First Affiliated Hospital of Xian Jiaotong University ward1 depattment of medical oncology ( Sit
Xi'an, Shaanxi, 710061, China
Shaanxi provincial people's hospital ( Site 0853)
Xi'an, Shaanxi, 710068, China
Shanghai Jiaotong University School of Medicine Ruijin Hospital-Cardiology Department ( Site 0855)
Shanghai, Shanghai Municipality, 200001, China
Zhongshan Hospital,Fudan University-Cardiology ( Site 0851)
Shanghai, Shanghai Municipality, 200032, China
Shanghai Tongji Hospital-Cardiovascular Department ( Site 0905)
Shanghai, Shanghai Municipality, 200065, China
Shanghai Yangpu District Central Hospital-Cardiology ( Site 0876)
Shanghai, Shanghai Municipality, 200090, China
Shanghai Xuhui Central Hospital-Cardiovascular Department ( Site 0872)
Shanghai, Shanghai Municipality, China
West China Hospital Sichuan University ( Site 0904)
Chengdu, Sichuan, 610041, China
The Second Hospital of Tianjin Medical University-Endocrinology ( Site 0902)
Tianjin, Tianjin Municipality, 300211, China
Tianjin Chest Hospital-Cardiology ( Site 0901)
Tianjin, Tianjin Municipality, 300222, China
Tianjin People' s Hospital ( Site 0867)
Tianjin, Tianjin Municipality, China
The First Affiliated Hospital, Zhejiang University ( Site 0907)
Hangzhou, Zhejiang, 310003, China
The Second Affiliated hospital of Zhejiang University school of medicine ( Site 0909)
Hangzhou, Zhejiang, 310052, China
Zhejiang Provincial People's Hospital ( Site 0914)
Hangzhou, Zhejiang, 311599, China
People's Hospital of Lishui City-department of cardiovascular ( Site 0862)
Lishui, Zhejiang, 323000, China
The First Affiliated Hospital of Wenzhou Medical University-Vasculocardiology Department ( Site 0874
Wenzhou, Zhejiang, 325000, China
Fundación Centro de Investigación Clínica CIC ( Site 0955)
Medellín, Antioquia, 050021, Colombia
Centro Cardiovascular Colombiano Clínica Santa María ( Site 0951)
Medellín, Antioquia, 050034, Colombia
Rodrigo Botero S.A.S ( Site 0953)
Medellín, Antioquia, 50030, Colombia
Clinica de la Costa S.A.S. ( Site 0954)
Barranquilla, Atlántico, 080020, Colombia
Corazon IPS ( Site 0964)
Barranquilla, Atlántico, 080020, Colombia
IPS Centro Científico Asistencial S.A.S ( Site 0952)
Barranquilla, Atlántico, 080020, Colombia
IPS Médicos Internistas de Caldas ( Site 0959)
Manizales, Caldas Department, 170004, Colombia
Instituto Del Corazón De Bucaramanga ( Site 0960)
Bucaramanga, Santander Department, 680002, Colombia
Fundación Cardiovascular de Colombia ( Site 0961)
Piedecuesta, Santander Department, 681017, Colombia
Fundacion Valle del Lili- CIC-Internal Medicine ( Site 0962)
Cali, Valle del Cauca Department, 760032, Colombia
Centro de Investigaciones Clinicas SAS ( Site 0957)
Cali, Valle del Cauca Department, 760036, Colombia
Clínica Imbanaco S.A.S ( Site 0963)
Cali, Valle del Cauca Department, Colombia
Fakultní nemocnice Brno Bohunice-Interni kardiologicka klinika ( Site 1058)
Brno, Brno-mesto, 625 00, Czechia
Vojenská Nemocnice Brno-Internal department ( Site 1055)
Brno, Brno-mesto, 636 00, Czechia
Nemocnice Slany-Interna - kardiologicka ambulance ( Site 1063)
Slaný, Central Bohemia, 274 01, Czechia
Klinika Dr. Pirka ( Site 1065)
Mladá Boleslav, Mlada Boleslav, 293 01, Czechia
Institut Klinicke a Experimentalni Mediciny-Klinika kardiologie ( Site 1052)
Prague, Praha 4, 14021, Czechia
Ustredni vojenska nemocnice-Oddeleni kardiologie ( Site 1054)
Prague, Praha 6, 169 02, Czechia
MUDr. Libor Nechvatal s.r.o. , Kardiologie ( Site 1057)
Brno, South Moravian, 602 00, Czechia
Fakultni Nemocnice u sv. Anny v Brne-I. interni kardioangiologicka klinika ( Site 1066)
Brno, South Moravian, 60200, Czechia
KardioBusak s.r.o. ( Site 1051)
Louny, 44001, Czechia
Vseobecna fakultni nemocnice v Praze-Centrum srdečního selhání ( Site 1059)
Prague, 12808, Czechia
KIGE ( Site 1060)
Znojmo, 66902, Czechia
Rigshospitalet-Cardiology ( Site 1161)
Copenhagen, Capital Region, 2100, Denmark
Amager Hospital ( Site 1163)
Copenhagen, Capital Region, 2300, Denmark
Herlev and Gentofte Hospital-Department of Cardiology ( Site 1158)
Hellerup, Capital Region, 2900, Denmark
Nordsjællands Hospital - Hillerød ( Site 1159)
Hillerød, Capital Region, 3400, Denmark
Hvidovre Hospital-259 ( Site 1151)
Hvidovre, Capital Region, 2650, Denmark
Aarhus Universitetshospital, Skejby ( Site 1160)
Aarhus, Central Jutland, 8200, Denmark
Regionshospitalet Viborg ( Site 1166)
Viborg, Central Jutland, 8800, Denmark
Sygehus Vendsyssel Hjoerring ( Site 1164)
Hjørring, North Denmark, 9800, Denmark
Holbæk Sygehus-Cardiology ( Site 1152)
Holbæk, Region Sjælland, 4300, Denmark
Roskilde Sygehus ( Site 1162)
Roskilde, Region Sjælland, 4000, Denmark
Slagelse Sygehus-Ambulatorium for Hjertesygdomme ( Site 1153)
Slagelse, Region Sjælland, 4200, Denmark
Sydvestjysk Sygehus Esbjerg-Hjertemedicinsk Projekt ( Site 1154)
Esbjerg, Region Syddanmark, 6700, Denmark
Svendborg Hospital Odense Universitets hospital-Kardiologisk Forskningsenhed ( Site 1156)
Svendborg, Region Syddanmark, 5700, Denmark
Centre Hospitalier Universitaire de Nice - Hopital Pasteur-Service cardiologie ( Site 1353)
Nice, Alpes-Maritimes, 06000, France
CHU Bordeaux Haut-Leveque ( Site 1362)
Pessac, Aquitaine, 33600, France
Centre Hospitalier Louis Pasteur ( Site 1360)
Le Coudray, Eure-et-Loir, 28630, France
CHU Rangueil-Cardiology ( Site 1351)
Toulouse, Haute-Garonne, 31059, France
CHU Charles Nicolle ( Site 1354)
Rouen, Haute-Normandie, 76031, France
Centre Hospitalier Régional Universitaire de Nancy - Hôpitau-Centre Investigation Clinique Plurithé
Vandœuvre-lès-Nancy, Lorraine, 54511, France
Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre ( Site 1356)
Le Kremlin-Bicêtre, Paris, 94270, France
Centre Hospitalier intercommunal de Toulon La Seyne sur Mer ( Site 1352)
Toulon, Provence-Alpes-Côte d'Azur Region, 83100, France
Hospices Civils de Lyon - Hopital Louis Pradel ( Site 1364)
Lyon, Rhone, 69677, France
CHD Vendee ( Site 1361)
La Roche-sur-Yon, Vendee, 85000, France
Pitie Salpetriere University Hospital ( Site 1363)
Paris, Île-de-France Region, 75013, France
Universitaetsklinikum Heidelberg-Klinik für Kardiologie, Angiologie und Pneumologie ( Site 1475)
Heidelberg, Baden-Wurttemberg, 69120, Germany
Klinikum Coburg ( Site 1464)
Coburg, Bavaria, Germany
Kardiologische Gemeinschaftspraxis ( Site 1460)
Nuremberg, Bavaria, 90402, Germany
Universitaetsklinikum Wuerzburg ( Site 1458)
Würzburg, Bavaria, 97080, Germany
ClinPhenomics CVC GmbH ( Site 1457)
Frankfurt am Main, Hesse, 60596, Germany
Klinikum Frankfurt Höchst ( Site 1463)
Frankfurt am Main, Hesse, 65929, Germany
Asklepios Klinik Langen ( Site 1473)
Langen, Hesse, 63225, Germany
Medizinische Hochschule Hannover ( Site 1476)
Hanover, Lower Saxony, 30625, Germany
Universitätsmedizin Greifswald ( Site 1470)
Greifswald, Mecklenburg-Vorpommern, 17475, Germany
St. Vinzenz-Hospital-Cardiology ( Site 1455)
Cologne, North Rhine-Westphalia, 50733, Germany
Klinikum Leverkusen ( Site 1453)
Leverkusen, North Rhine-Westphalia, 51375, Germany
Kliniken Maria Hilf-Klinik für Kardiologie ( Site 1454)
Mönchengladbach, North Rhine-Westphalia, 41063, Germany
Gemeinschaftspraxis Dr. Fabian Krämer, Dr. Ulrich Overhoff ( Site 1459)
Siegen, North Rhine-Westphalia, 57072, Germany
Klinikum Ludwigshafen ( Site 1456)
Ludwigshafen am Rhein, Rhineland-Palatinate, 67063, Germany
Marienhaus Klinikum St. Elisabeth Neuwied ( Site 1452)
Neuwied, Rhineland-Palatinate, 56564, Germany
Staedtisches Klinikum Dresden-2. Medizinische Klinik ( Site 1468)
Dresden, Saxony, 01067, Germany
Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien ( Site 1477)
Dresden, Saxony, 01277, Germany
Herzzentrum Dresden GmbH Universitätsklinik ( Site 1469)
Dresden, Saxony, 01307, Germany
Katholisches Krankenhaus St. Johann Nepomuk ( Site 1462)
Erfurt, Thuringia, 99097, Germany
Praxis Rankestrasse ( Site 1461)
Berlin, 10789, Germany
Cardiologicum Hamburg ( Site 1467)
Hamburg, 22041, Germany
General Hospital of Athens Hippokratio ( Site 1552)
Athens, Attica, 115 27, Greece
Alexandra Hospital-HEART FAILURE AND CARDIO-ONCOLOGY UNIT ( Site 1559)
Athens, Attica, 115 28, Greece
General Hospital of Athens "G. Gennimatas"-General Hospital of Athens "G.Gennimatas" ( Site 1561)
Athens, Attica, 11527, Greece
Konstantopoulio General Hospital-Cardiology Clinic ( Site 1553)
Athens, Attica, 142 33, Greece
ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1556)
Chaïdári, Attica, 124 62, Greece
Hygeia Hospital-6th cardiology clinic ( Site 1560)
Marousi, Attica, 151 23, Greece
University Hospital of Alexandroupolis-First Department of Internal Medicine ( Site 1551)
Alexanroupolis, Evros, 681 00, Greece
University General Hospital of Larissa ( Site 1555)
Larissa, Thessaly, 411 10, Greece
University Hospital of Ioannina-2nd Department of Cardiology ( Site 1554)
Ioannina, West Greece, 455 00, Greece
AHEPA University General Hospital of Thessaloniki-1st Cardiology Clinic ( Site 1558)
Thessaloniki, 546 36, Greece
European Interbalkan Medical Center-2nd Department of Cardiology ( Site 1557)
Thessaloniki, 57001, Greece
Unidad De Diagnostico Cardiologico ( Site 1652)
Guatemala City, 01001, Guatemala
Clinica Medica ( Site 1651)
Guatemala City, 01010, Guatemala
Unidad De Diagnostico Cardiologico ( Site 1654)
Guatemala City, Guatemala
Grantham Hospital ( Site 1753)
Aberdeen, 999077, Hong Kong
Queen Mary Hospital-Medicine - Cardiology ( Site 1752)
Hksar, Hong Kong
Princess Margaret Hospital ( Site 1755)
Hong Kong, Hong Kong
Prince of Wales Hospital ( Site 1751)
Shatin, NT, Hong Kong
CoroMed ( Site 1867)
Pécs, Baranya, 7623, Hungary
Pécsi Tudományegyetem Klinikai Központ ( Site 1865)
Pécs, Baranya, 7624, Hungary
Private Practice - Dr. Lakatos Ferenc ( Site 1854)
Békéscsaba, Bekes County, 5600, Hungary
Békés Megyei Központi Kórház Pándy Kálmán Tagkórház-Cardiology ( Site 1878)
Gyula, Bekes County, 5700, Hungary
Bacs-Kiskun Megyei Korhaz-I. Belgyógyászat - Kardiológia ( Site 1873)
Kecskemét, Bács-Kiskun county, 6000, Hungary
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Belgyógyászati Klinika ( Site 1874)
Szeged, Csongrád megye, 6725, Hungary
TaNa Med ( Site 1866)
Mosonmagyaróvár, Győr-Moson-Sopron, 9200, Hungary
Flor Ferenc Hospital of Pest County-5th Department of Internal Medicine ( Site 1852)
Kistarcsa, Pest County, 2143, Hungary
CMed Rehabilitacios es Diagnosztikai Kozpont ( Site 1877)
Székesfehérvár, Szekesfehervar, 8000, Hungary
Tolna Megyei Balassa János Kórház ( Site 1868)
Szekszárd, Szekszard, 7100, Hungary
DRC Gyógyszervizsgáló Központ ( Site 1869)
Balatonfüred, Veszprém megye, 8230, Hungary
Szent Rókus Kórház ( Site 1858)
Budapest, 1085, Hungary
Gottsegen György Országos Kardiovaszkuláris Intézet ( Site 1851)
Budapest, 1096, Hungary
Semmelweis University-Városmajori Szív- és Érgyógyászati Klinika ( Site 1855)
Budapest, 1122, Hungary
Óbudai Egészségügyi Centrum ( Site 1861)
Budapest, 1932, Hungary
Medifarma 98 Kft-Outpatient Clinic ( Site 1859)
Nyíregyháza, 4400, Hungary
OEC Clinical Research - Zalaegerszeg ( Site 1864)
Zalaegerszeg, 8900, Hungary
St. Michael's Hospital ( Site 1955)
Dún Laoghaire, Dublin, A96 D628, Ireland
St. James's Hospital-Cardiology ( Site 1951)
Dublin, D08 E9P6, Ireland
Assuta Ashdod Medical Center-Cardiology ( Site 2063)
Ashdod, 7747629, Israel
Hillel Yaffe Medical Center-Heart Institute ( Site 2058)
Hadera, 3810101, Israel
Rambam Health Care Campus-Cardiology ( Site 2053)
Haifa, 3109601, Israel
Shaare Zedek Medical Center-Cardiology ( Site 2055)
Jerusalem, 9013102, Israel
Hadassah Medical Center-Heart Institute ( Site 2062)
Jerusalem, 9112001, Israel
Galilee Medical Center-Cardiology ( Site 2051)
Nahariya, 2210001, Israel
Rabin Medical Center-Cardiology - CHF ( Site 2052)
Petah Tikva, 49100, Israel
Sheba Medical Center-Leviev Heart Center ( Site 2064)
Ramat Gan, 5262100, Israel
Kaplan Medical Center-Heart Institution ( Site 2054)
Rehovot, 7610001, Israel
Yitzhak Shamir Medical Center-Cardiology ( Site 2060)
Ẕerifin, 609300, Israel
Azienda Ospedaliero Universitaria S.Anna ( Site 2152)
Cona, Emilia-Romagna, 44124, Italy
Cattinara Hospital-Cardiovascular Department ( Site 2162)
Trieste, Friuli Venezia Giulia, 34149, Italy
Policlinico Umberto I ( Site 2166)
Rome, Lazio, 00161, Italy
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-U.O.C. Cardiologia ( Site 2161)
Milan, Lombardy, 20122, Italy
Centro Cardiologico Monzino-Heart Failure Unit ( Site 2153)
Milan, Lombardy, 20138, Italy
ASST Grande Ospedale Metropolitano Niguarda-Unità Ricerche Cliniche della Cardiologia 4 ( Site 2159)
Milan, Milano, 20162, Italy
IRCCS San Raffaele Pisana-riabilitazione cardiologica ( Site 2156)
Rome, Roma, 00163, Italy
ospedale le scotte ( Site 2163)
Siena, Tuscany, 53100, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-Cardiologia 1 ( Site 2151)
Bergamo, 24127, Italy
IRCCS - AOU di Bologna-Dept. of Medical and Surgical sciences ( Site 2158)
Bologna, 40138, Italy
Azienda Ospedaliera Spedali Civili di Brescia-Cardiology- Day Hospital ( Site 2154)
Brescia, 25123, Italy
Fondazione IRCCS Policlinico San Matteo-Cardiology ( Site 2157)
Pavia, 27100, Italy
University of Perugia ( Site 2164)
Perugia, 06132, Italy
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 2165)
Torino, 10126, Italy
Hospital Sultanah Bahiyah-Department of Cardiology ( Site 2355)
Alor Star, Kedah, 05460, Malaysia
Hospital Universiti Sains Malaysia-Medical Department ( Site 2357)
Kubang Kerian, Kelantan, 16150, Malaysia
University Malaya Medical Centre ( Site 2351)
Lembah Pantai, Kuala Lumpur, 59100, Malaysia
Hospital Tengku Ampuan Afzan ( Site 2353)
Kuantan, Pahang, 25100, Malaysia
Hospital Queen Elizabeth II ( Site 2359)
Kota Kinabalu, Sabah, 88300, Malaysia
Sarawak Heart Centre ( Site 2352)
Kota Samarahan, Sarawak, 94300, Malaysia
UiTM Sungai Buloh Campus ( Site 2354)
Sungai Buloh, Selangor, 47000, Malaysia
Hospital Sultanah Nur Zahirah-Jabatan Perubatan ( Site 2360)
Kuala Terengganu, Terengganu, 20400, Malaysia
Medivest Centro de Investigación Integral ( Site 2460)
Chihuahua City, Chihuahua, 31203, Mexico
CIMAB SA de CV ( Site 2456)
Torreón, Coahuila, 27000, Mexico
Centro de Investigacion Cardiovascular y Metabólica ( Site 2465)
Tijuana, Estado de Baja California, 22500, Mexico
Hospital General de Acapulco ( Site 2469)
Acapulco de Juárez, Guerrero, 39901, Mexico
Grupo Ollin Care ( Site 2476)
Pachuca, Hidalgo, 42000, Mexico
Unidad de Investigaci�n Cl�nica Cardiometabolica de Occidente ( Site 2466)
Guadalajara, Jalisco, 44150, Mexico
Cardiocent de Guadalajara S.C. ( Site 2464)
Guadalajara, Jalisco, 44160, Mexico
Instituto Jalisciense de Metabolismo SC ( Site 2467)
Guadalajara, Jalisco, 44670, Mexico
HOSPITAL GENERAL DE MEXICO DR. EDUARDO LICEAGA ( Site 2478)
Mexico City, Mexico City, 06720, Mexico
Centro de Imagen y Tecnología en Intervención Cardiovascular ( Site 2477)
Mexico City, Mexico City, 10400, Mexico
Instituto Nacional de Cardiologia Ignacio Chavez ( Site 2454)
Mexico City, Mexico City, 14080, Mexico
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 2474)
Mexico City, Mexico City, 14080, Mexico
Unidad biomedica avanzada monterrey ( Site 2462)
Monterrey, Nuevo León, 64460, Mexico
Unidad Médica para la Salud Integral ( Site 2472)
San Nicolás de los Garza, Nuevo León, 66465, Mexico
Centro de Atención e Investigación Cardiovascular del Potosí ( Site 2453)
San Luis Potosí City, San Luis Potosí, 78200, Mexico
Centro de Estudios de Alta Especialidad de Sinaloa ( Site 2463)
Mazatlán, Sinaloa, 82113, Mexico
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares ( Site 2468)
Ciudad Madero, Tamaulipas, 89440, Mexico
Consultorio de Medicina Especilizada del Sector Privado ( Site 2455)
Xalapa, Veracruz, 91193, Mexico
Hospital Angeles Xalapa ( Site 2451)
Xalapa, Veracruz, 91193, Mexico
Medical Care and Research SA de CV ( Site 2461)
Mérida, Yucatán, 97070, Mexico
Fundación Cardiovascular de Aguascalientes A.C. ( Site 2473)
Aguascalientes, 20230, Mexico
Oaxaca Site Management Organization ( Site 2459)
Oaxaca City, 68000, Mexico
Centro de Investigacion Clinica de Oaxaca ( Site 2457)
Oaxaca City, 68020, Mexico
Christchurch Heart Institute ( Site 2651)
Christchurch, Canterbury, 8011, New Zealand
Dunedin Hospital-Cardiology Department ( Site 2653)
Dunedin, Otago, 9016, New Zealand
Waikato Hospital-Cardiology Clinical Trials Unit ( Site 2654)
Hamilton, Waikato Region, 3204, New Zealand
Hutt Valley District Health board HVDHB-Cardiology Research Unit ( Site 2652)
Lower Hutt, Wellington Region, 5010, New Zealand
North Shore Hospital-Cardiology Research ( Site 2656)
Auckland, 0622, New Zealand
Auckland City Hospital ( Site 2659)
Auckland, 1023, New Zealand
Middlemore Clinical Trials ( Site 2658)
Auckland, 2025, New Zealand
Centro de investigacion Clínica Trujillo-Medical specialties ( Site 2860)
Trujillo, La Libertad, 13001, Peru
Instituto Nacional Cardiovascular INCOR Carlos Peschiera Carrillo - EsSalud ( Site 2855)
Jesús María, Lima, 15072, Peru
Hospital Alberto Sabogal Sologuren ( Site 2851)
Bellavista, Qallaw, 07011, Peru
Clínica Vesalio-Cardiology ( Site 2854)
Lima, 15036, Peru
Clínica Javier Prado ( Site 2853)
Lima, 15046, Peru
Clínica El Golf-Cardiologia ( Site 2857)
Lima, 15076, Peru
Clínica Providencia ( Site 2856)
Lima, 15088, Peru
Hospital Cayetano Heredia-Servicio de cardiologia ( Site 2852)
Lima, Lima 31, Peru
Clínica Belén ( Site 2858)
Piura, 20000, Peru
NZOZ Centrum Medyczne KERmed ( Site 3066)
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-231, Poland
Praktyka Lekarska Lidia Pawlowicz ( Site 3053)
Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland
Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu-Oddz.Klin.Kardiologii i Int.T.Kard. ( Si
Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland
Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe ( Site 3062)
Chrzanów, Lesser Poland Voivodeship, 32-500, Poland
Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Sp. J. ( Site 3061)
Krakow, Lesser Poland Voivodeship, 31-216, Poland
Private Practice - Dr. Robert Witek-Ośrodek Badań Klinicznych "METABOLICA" Lek. Robert Witek ( Site
Tarnów, Lesser Poland Voivodeship, 33-100, Poland
Beata Miklaszewicz & Dariusz Dabrowski CARDIAMED s.j. ( Site 3070)
Legnica, Lower Silesian Voivodeship, 59-220, Poland
Instytut Chorób Serca, Zakład Badań Klinicznych Chorób Układu Krążenia ( Site 3057)
Wrocaw, Lower Silesian Voivodeship, 50-556, Poland
NZOZ Twoja Przychodnia ( Site 3051)
Lublin, Lublin Voivodeship, 20-857, Poland
SP ZOZ w Puławach- Oddział Kardiologii ( Site 3071)
Puławy, Lublin Voivodeship, 24-100, Poland
ETG Warszawa ( Site 3052)
Warsaw, Masovian Voivodeship, 02-793, Poland
Polsko-Amerykańskie Kliniki Serca ( Site 3077)
Kędzierzyn-Koźle, Opole Voivodeship, 47-200, Poland
Centrum Medyczne Medyk ( Site 3065)
Rzeszów, Podkarpackie Voivodeship, 35-055, Poland
Centrum Medyczne Dr Sudnik s.c. Wanda i Jerzy Sudnik ( Site 3073)
Sokółka, Podlaskie Voivodeship, 16-100, Poland
Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii Lek. med. Krzysztof Cymerman
Gdynia, Pomeranian Voivodeship, 81-157, Poland
Cooperativa De Facultad Medica Sanacoop-Instituto Sanacoop ( Site 3151)
Bayamón, 00961, Puerto Rico
Private Practice - Dr. Yolanda Figueroa-Torres ( Site 3156)
Humacao, 00791, Puerto Rico
Research and Cardiovascular Corp. ( Site 3152)
Ponce, 00717, Puerto Rico
Caparra Internal Medicine ( Site 3155)
Río Grande, 00745, Puerto Rico
VA Caribbean Healthcare System ( Site 3157)
San Juan, 00921-3201, Puerto Rico
Ivanovo Regional Healthcare Institution Cardiology Dispensary ( Site 3265)
Ivanovo, Ivanovo Oblast, 153012, Russia
Krasnodar Regional Clinical Hospital Number 1 S.V. Ochapovskogo ( Site 3281)
Krasnodar, Krasnodarskiy Kray, 350086, Russia
City Hospital No. 4 ( Site 3269)
Sochi, Krasnodarskiy Kray, 354057, Russia
First Pavlov State Medical University of Saint Petersburg-Сardiology department ( Site 3257)
Saint Petersburg, Leningradskaya Oblast', 197022, Russia
State budgetary Healthcare Institution of the city of Moscow "V. V. Vinogradov City Clinical Hospita
Moscow, Moscow, 117292, Russia
Omsk Regional Clinical Health Service Number 9 ( Site 3296)
Omsk, Omsk Oblast, 644018, Russia
Perm Regional Hospital for War Veterans ( Site 3272)
Perm, Permskiy Kray, 614990, Russia
Rostov State Medical University ( Site 3259)
Rostov-on-Don, Rostov Oblast, 344022, Russia
Rostov-on-Don City Emergency Hospital ( Site 3271)
Rostov-on-Don, Rostov Oblast, 344068, Russia
Ryazan State Medical University named after Academician I.P. Pavlova ( Site 3260)
Ryazan, Ryazan Oblast, 390005, Russia
First Pavlov State Medical University of Saint Petersburg ( Site 3288)
Saint Petersburg, Sankt-Peterburg, 197022, Russia
Almazov National Medical Research Centre ( Site 3320)
Saint Petersburg, Sankt-Peterburg, 197341, Russia
Pokrovskaya Municipal Hospital ( Site 3252)
Saint Petersburg, Sankt-Peterburg, 199106, Russia
Pokrovskaya Municipal Hospital-1-st cardiology department ( Site 3251)
Saint Petersburg, Sankt-Peterburg, 199106, Russia
Astarta Clinic ( Site 3276)
Saint Petersburg, Sankt-Peterburg, 199226, Russia
Clinical Hospital S.R.Mirotvortseva name SSMU ( Site 3254)
Saratov, Saratov Oblast, 410054, Russia
Interregional Clinical Diagnostic Center-Department of Clinical Trials ( Site 3307)
Kazan', Tatarstan, Respublika, 420101, Russia
Volgograd State Medical University ( Site 3258)
Volgograd, Volgograd Oblast, 400131, Russia
Institute for Medical Research ( Site 3316)
Saint Petersburg, 196084, Russia
National Heart Centre Singapore ( Site 3351)
Singapore, Central Singapore, 169609, Singapore
Tan Tock Seng Hospital ( Site 3353)
Singapore, Central Singapore, 308433, Singapore
Changi General Hospital ( Site 3356)
Singapore, South East, 529889, Singapore
National University Heart Centre, Singapore-Department of Cardiology ( Site 3355)
Singapore, South West, 119074, Singapore
Universitas Private Hospital-Cardiology Research ( Site 3453)
Bloemfontein, Free State, 9321, South Africa
Lenasia Clinical Trial Centre - Johannesburg ( Site 3470)
Johannesburg, Gauteng, 1821, South Africa
Netcare Sunninghill Hospital ( Site 3457)
Johannesburg, Gauteng, 2196, South Africa
Midrand Medical Centre ( Site 3466)
Midrand, Gauteng, 1685, South Africa
University of Pretoria - Faculty of Health Sciences-CRU ( Site 3462)
Pretoria, Gauteng, 0001, South Africa
Clinical Trial Systems ( Site 3452)
Pretoria, Gauteng, 0186, South Africa
Jongaie Research ( Site 3469)
Pretoria West, Gauteng, 0183, South Africa
Chris Hani Baragwanath Academic Hospital ( Site 3455)
Soweto, Gauteng, 2013, South Africa
Enhancing Care Foundation ( Site 3456)
Durban, KwaZulu-Natal, 4001, South Africa
Tiervlei Trial Centre ( Site 3461)
Bellville, Cape Town, Western Cape, 7530, South Africa
TREAD Research ( Site 3451)
Cape Town, Western Cape, 7500, South Africa
Professor Ntsekhe Cardiology Clinic ( Site 3454)
Cape Town, Western Cape, 7925, South Africa
Excellentis Clinical Trial Consultants ( Site 3464)
George, Western Cape, 6529, South Africa
Paarl Research Centre ( Site 3468)
Paarl, Western Cape, 7646, South Africa
Gachon University Gil Medical Center ( Site 3559)
Namdong-gu, Incheon, 21565, South Korea
Yonsei University-Wonju Severance Christian Hospital ( Site 3555)
Wŏnju, Kang-won-do, 26426, South Korea
Chonnam National University Hospital ( Site 3558)
Gwangju, Kwangju-Kwangyokshi, 61469, South Korea
Hallym University Sacred Heart Hospital-Cardiovascular center ( Site 3556)
Anyang-si, Kyonggi-do, 14068, South Korea
Chungbuk National University Hospital-Internal medicine ( Site 3551)
Cheongju-si, North Chungcheong, 28644, South Korea
Pusan National University Hospital-Internal Medicine ( Site 3553)
Busan, Pusan-Kwangyokshi, 49241, South Korea
Chungnam national university hospital ( Site 3554)
Junggu, Taejon-Kwangyokshi, 35015, South Korea
Seoul National University Hospital ( Site 3557)
Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System ( Site 3552)
Seoul, 03722, South Korea
Hospital Germans Trias i Pujol ( Site 3664)
Badalona, Barcelona, 08916, Spain
Hospital Quiron Barcelona ( Site 3655)
Barcelona, Catalonia, 08023, Spain
Hospital Universitari de Bellvitge-Unitat Multidisciplinar d'Insuficiència Cardíaca Comunitària (UM
L'Hospitalet de Llobregat, Catalonia, 08907, Spain
CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 3666)
A Coruña, La Coruna, 15006, Spain
CHUS - Hospital Clinico Universitario-Cardiology - Clinical Research Unit ( Site 3651)
Santiago de Compostela, La Coruna, 15706, Spain
Hospital Universitario Ramón y Cajal ( Site 3662)
Madrid, Madrid, Comunidad de, 28034, Spain
HOSPITAL CLINICO DE VALENCIA ( Site 3656)
Valencia, Valenciana, Comunitat, 46010, Spain
Parc de Salut Mar - Hospital del Mar ( Site 3663)
Barcelona, 08003, Spain
Hospital Universitari Vall d'Hebron ( Site 3659)
Barcelona, 08035, Spain
Hospital Clinico San Carlos-Cardiology ( Site 3661)
Madrid, 28040, Spain
Hospital Universitario La Paz ( Site 3665)
Madrid, 28046, Spain
Hospital Universitario Virgen de Valme ( Site 3654)
Seville, 41014, Spain
Falu Lasarett-Dep of Cardiology ( Site 3756)
Falun, Dalarna County, 791 31, Sweden
Clemenstorgets Hjartmottagning ( Site 3755)
Lund, Skåne County, 22221, Sweden
Karolinska Universitetssjukhuset Solna-Heart and Vascular theme ( Site 3759)
Solna, Stockholm County, 171 64, Sweden
Aleris Specialistvård Sabbatsberg ( Site 3762)
Stockholm, Stockholm County, 113 61, Sweden
Akardo Med Site ( Site 3763)
Stockholm, Stockholm County, 117 27, Sweden
Skellefteå Lasarett-Research unit, floor 5 ( Site 3760)
Skellefteå, Västerbotten County, 931 86, Sweden
Västmanlands Sjukhus Västerås ( Site 3757)
Västerås, Västmanland County, 72189, Sweden
Sahlgrenska Universitetssjukhuset-Cardiology Research Unit ( Site 3753)
Gothenburg, Västra Götaland County, 413 45, Sweden
Universitetssjukhuset Örebro-Heart-Lung-Physiology Clinic ( Site 3754)
Örebro, Örebro County, 701 85, Sweden
Changhua Christian Hospital ( Site 3857)
Changhua County, Changhua, 50006, Taiwan
Mackay Memorial Hospital-Hsinchu ( Site 3852)
Hsinchu, Hsinchu, 300, Taiwan
Kaohsiung Medical University Hospital ( Site 3856)
Kaohsiung City, 807, Taiwan
Taichung Veterans General Hospital ( Site 3855)
Taichung, 407, Taiwan
Taipei Veterans General Hospital-General Clinical Research Center ( Site 3851)
Taipei, 11217, Taiwan
Chang Gung Medical Foundation-Linkou Branch ( Site 3854)
Taoyuan District, 333, Taiwan
Ege University Medicine of Faculty-Cardilogy Department ( Site 4054)
Bornova, İzmir, 35100, Turkey (Türkiye)
Afyon Kocatepe Üniversitesi Tıp Fakültesi-Cardiology Department ( Site 4058)
Afyonkarahisar, 03200, Turkey (Türkiye)
Hacettepe Universitesi ( Site 4061)
Ankara, 06230, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi-cardiology ( Site 4053)
Ankara, 06800, Turkey (Türkiye)
Antalya Egitim ve Arastırma Hastanesi-Cardiology ( Site 4064)
Antalya, 07100, Turkey (Türkiye)
Eskisehir Osmangazi University-Cardiology ( Site 4052)
Eskişehir, 26480, Turkey (Türkiye)
Istanbul University Cerrahpasa Medical School Internal Diseases Institute-CARDIOLOGY INSTITUTE ( Sit
Istanbul, 34098, Turkey (Türkiye)
Başkent Üniversitesi Istanbul Hastanesi ( Site 4057)
Istanbul, 34662, Turkey (Türkiye)
Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi ( Site 4063)
Istanbul, 34668, Turkey (Türkiye)
Dokuz Eylül Üniversitesi-CARDIOLOGY ( Site 4055)
Izmir, 35340, Turkey (Türkiye)
Medical Park zmir Hastanesi-cardiology ( Site 4059)
Izmir, 35510, Turkey (Türkiye)
Kocaeli Üniversitesi-Cardiology ( Site 4060)
Kocaeli, 41380, Turkey (Türkiye)
Mersin University ( Site 4056)
Mersin, 33343, Turkey (Türkiye)
Communal non-profit enterprise "Cherkasy Regional Hospital of Сherkasy Regional Council" ( Site 4292
Cherkasy, Cherkasy Oblast, 18000, Ukraine
Cherkasy Regional Hospital-Cardiorheumatology ( Site 4283)
Cherkasy, Cherkasy Oblast, 18009, Ukraine
Clinical medical and diagnostic center Limited Liability Company "Simedgroup" ( Site 4284)
Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76000, Ukraine
Municipal Non-commercial Enterprise "Ivano-Frankivsk Regional Clinical Cardiology Center of Ivano-Fr
Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine
Central clinical hospital - Ukrzalisnytsia-2nd Cardiology ( Site 4306)
Kharkiv, Kharkivs’ka Oblast’, 61000, Ukraine
Communal non-profit enterprise "City Clinical Hospital # 27" of Kharkiv City Council ( Site 4262)
Kharkiv, Kharkivs’ka Oblast’, 61000, Ukraine
L.T. Mala National Institute of Therapy of NAMS of Ukraine-Clinical Pharmacology and Pharmacogeneti
Kharkiv, Kharkivs’ka Oblast’, 61039, Ukraine
Municipal Non-Profit Enterprise -City clinical hospital No8 of Kharkiv city council ( Site 4278)
Kharkiv, Kharkivs’ka Oblast’, 61176, Ukraine
Khmelnytskyi Regional Cardiovascular Center-department of invasive cardiology and interventional ra
Khmelnytskyi, Khmelnytskyi Oblast, 29001, Ukraine
Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrain
Kiev, Kyiv Oblast, 03049, Ukraine
Medical Center of Limited Liability Company "Medical Center "Consilium Medical" ( Site 4257)
Kiev, Kyiv Oblast, 04050, Ukraine
Medbud Clinic ( Site 4265)
Kyiv, Kyivska Oblast, 03037, Ukraine
State Institution National Scientific Center M.D. Strazhesko-Essential Hypertension ( Site 4259)
Kyiv, Kyivska Oblast, 03680, Ukraine
Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council ( Site 42
Odesa, Odesa Oblast, 65025, Ukraine
Ukrayins'kyy Derzhavnyy Naukovo-Doslidnyy Instytut Rebilitatsiyi Invalidiv ( Site 4274)
Vinnytsia, Vinnytsia Oblast, 21029, Ukraine
Lutsk City Clinical Hospital-Center for Cardiovascular Disease ( Site 4255)
Lutsk, Volyn Oblast, 43024, Ukraine
Zakarpattya Regional Clinical Cardiology Dispensary-Dept. of Hospital Therapy, Uzhhorod National Un
Uzhhorod, Zakarpattia Oblast, 88000, Ukraine
Communal Non-profit Enterprise "City Hospital #6" Zaporizhzhia City Counci-Therapy department ( Site
Zaporizhia, Zaporizhzhia Oblast, 69035, Ukraine
Communal nonprofit enterprise "City Hospital #9" of Zaporizhzhia City Council ( Site 4251)
Zaporizhia, Zaporizhzhia Oblast, 69065, Ukraine
Communal Enterprise "Hospital #1" of Zhytomyr City Council-Advisory and Treatment department of Sci
Zhytomyr, Zhytomyr Oblast, 10002, Ukraine
Consultative - Diagnostic Centre of Pechersky District-Therapeutic department ( Site 4307)
Kyiv, 01103, Ukraine
MNE " Kyiv City Clinical Emergency Hospital" of Kyiv Regional Council (KCSA) ( Site 4256)
Kyiv, 02166, Ukraine
State Institution National Scientific Center M.D. Strazhesko-Department of clinical arrhythmology a
Kyiv, 03151, Ukraine
State Institution National Scientific Center M.D. Strazhesko-Resuscitation and Intensive care ( Site
Kyiv, 03680, Ukraine
Cumberland Infirmary ( Site 4174)
Carlisle, Cumbria, CA2 7HY, United Kingdom
West Cumberland Hospital ( Site 4176)
Whitehaven, Cumbria, CA28 8JG, United Kingdom
Chesterfield Royal Hospital ( Site 4159)
Calow Chesterfield, Derbyshire, S44 5BL, United Kingdom
Ninewells Hospital and Medical School-Cardiology ( Site 4164)
Dundee, Dundee City, DD1 9SY, United Kingdom
Carmel Medical Practice ( Site 4152)
Darlington, England, DL3 7RD, United Kingdom
Russells Hall Hospital ( Site 4153)
Dudley, England, DY1 2HQ, United Kingdom
King's College Hospital-Cardiac Research Department ( Site 4154)
London, England, SE5 9RS, United Kingdom
St. George's Hospital-Cardiology Clinical Academic Group ( Site 4156)
London, England, SW17 0QT, United Kingdom
Prince Charles Hospital ( Site 4171)
Merthyr Tydfil, Great Britain, CF47 9DT, United Kingdom
Layton Medical Centre ( Site 4184)
Blackpool, Lancashire, FY3 7EN, United Kingdom
Ulster Hospital ( Site 4185)
Belfast, Lisburn And Castlereagh, BT16 1RH, United Kingdom
William Harvey Heart Centre ( Site 4169)
London, London, City of, EC1M 5PZ, United Kingdom
Craigavon Area Hospital ( Site 4162)
Belfast, Northern Ireland, BT63 5QQ, United Kingdom
Princess of Wales Hospital ( Site 4178)
Bridgend, Wales, CF31 1RQ, United Kingdom
Walsall Manor Hospital ( Site 4179)
West Midlands, Walsall, WS2 9PS, United Kingdom
Worcestershire Royal Hospital-Cardiology Research Department ( Site 4181)
Worcester, Worcestershire, WR5 1DD, United Kingdom
Blackpool Victoria Hospital ( Site 4161)
Blackpool, FY3 8NR, United Kingdom
University Hospital Coventry & Warwickshire-Research & Development ( Site 4170)
Coventry, CV2 2DX, United Kingdom
The Adam Practice ( Site 4180)
Poole, BH16 5PW, United Kingdom
University Hospital of North Tees ( Site 4172)
Stockton-on-Tees, TS19 8PE, United Kingdom
Related Publications (4)
Butler J, Usman MS, Anstrom KJ, Blaustein RO, Bonaca MP, Ezekowitz JA, Freitas C, Lam CSP, Lewis EF, Lindenfeld J, McMullan CJ, Mentz RJ, O'Connor C, Rosano GMC, Saldarriaga CI, Senni M, Udelson J, Voors AA, Zannad F. Soluble guanylate cyclase stimulators in patients with heart failure with reduced ejection fraction across the risk spectrum. Eur J Heart Fail. 2022 Nov;24(11):2029-2036. doi: 10.1002/ejhf.2720. Epub 2022 Nov 16.
PMID: 36250238RESULTReddy YNV, Butler J, Anstrom KJ, Blaustein RO, Bonaca MP, Corda S, Ezekowitz JA, Lam CSP, Lewis EF, Lindenfeld J, McMullan CJ, Mentz RJ, O'Connor C, Patel M, Ponikowski P, Rosano GMC, Saldarriaga CI, Senni M, Udelson J, Voors AA, Zannad F. Vericiguat Global Study in Participants with Chronic Heart Failure: Design of the VICTOR trial. Eur J Heart Fail. 2025 Feb;27(2):209-218. doi: 10.1002/ejhf.3501. Epub 2024 Oct 30.
PMID: 39473305RESULTButler J, McMullan CJ, Anstrom KJ, Barash I, Bonaca MP, Borentain M, Corda S, Ezekowitz JA, Felker GM, Gates D, Lam CSP, Lewis EF, Lindenfeld J, Mentz RJ, O'Connor CM, Ponikowski P, Reddy YNV, Rosano GMC, Saldarriaga C, Senni M, She L, Teixeira PP, Udelson J, Urbinati A, Vlajnic V, Voors AA, Xing A, Patel MJ, Zannad F; VICTOR Study Group. Vericiguat in patients with chronic heart failure and reduced ejection fraction (VICTOR): a double-blind, placebo-controlled, randomised, phase 3 trial. Lancet. 2025 Sep 27;406(10510):1341-1350. doi: 10.1016/S0140-6736(25)01665-4. Epub 2025 Aug 30.
PMID: 40897189RESULTKhan MS, Grayburn PA, Butler J. Cardiac reverse remodelling with vericiguat: Victory or no victory? Eur J Heart Fail. 2023 Jul;25(7):1022-1024. doi: 10.1002/ejhf.2883. Epub 2023 May 25. No abstract available.
PMID: 37191077DERIVED
Related Links
MeSH Terms
Interventions
Results Point of Contact
- Title
- Senior Vice President, Global Clinical Development
- Organization
- Merck Sharp & Dohme LLC
Study Officials
- STUDY DIRECTOR
Medical Director
Merck Sharp & Dohme LLC
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 18, 2021
First Posted
October 26, 2021
Study Start
November 2, 2021
Primary Completion
November 20, 2024
Study Completion
February 5, 2025
Last Updated
December 19, 2025
Results First Posted
December 19, 2025
Record last verified: 2025-12
Data Sharing
- IPD Sharing
- Will share
https://trialstransparency.msdclinicaltrials.com/pdf/ProcedureAccessClinicalTrialData.pdf