Resistance Training in Adults With Obesity

NCT05092061 | Completed

• 1 other identifier: 246888
• Study Type: interventional
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this project is two-fold: (1) to assess if two different resistance training protocols elicit different responses in the acute phase and (2) to assess if the same two different protocols will elicit different long-term responses on muscular strength, body composition and cardiometabolic health. The project will include 30 adults with obesity (defined as BMI ≥ 30 or abdominal obesity according to the International Diabetes Federation). In the acute phase blood lactate, heart rate, enjoyment and perceived exertion will be assessed after the two resistance training protocols. In addition, the mean 24-h blood glucose concentration after exercise will be compared between the two protocols. For the long-term effects blood markers of cardiometabolic health, blood pressure, body composition, objectively measured physical activity and physical fitness will be assessed before and after the intervention. Also, perceived health-related quality of life will be assessed before and after the intervention.

Conditions

Overweight and Obesity

Keywords

Exercise therapy; Muscular strength; Resistance training; Fitness testing; Healthy lifestyle

Outcome Measures

Primary Outcomes (1)

• Glycated haemoglobin (HbA1c)

  7 weeks

Secondary Outcomes (16)

• Fasting glucose

  7 weeks

• Blood lipid concentration

  7 weeks

• C-reactive protein

  7 weeks

• Systolic blood pressure

  7 weeks

• Diastolic blood pressure

  7 weeks

Study Arms (2)

Moderate-repetition resistance training

EXPERIMENTAL

The participants will undergo a full-body resistance training protocol with moderate repetitions (6-12), moderate load (70-85% of 1RM), and moderate rest between sets (60-90s). Training will be undertaken three times per week.

Other: Moderate-repetition resistance training

High-repetition resistance training

EXPERIMENTAL

The participants will undergo a full-body resistance training protocol with high repetitions (15+), low load (\<60% of 1RM), and short rest between sets (30s). Training will be undertaken three times per week.

Other: High-repetition resistance training

Interventions

Moderate-repetition resistance training OTHER

Will undertake resistance training with moderate loads, and moderate repetitions 3 times per week for 7 weeks.

Moderate-repetition resistance training

High-repetition resistance training OTHER

Will undertake resistance training with low loads, and high repetitions 3 times per week for 7 weeks.

High-repetition resistance training

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Obesity (BMI ≥ 30) or
• Central obesity (defined according to the International Diabetes Federation).

You may not qualify if:

• Unstable angina
• recent cardiac infarction (last 4 weeks)
• uncompensated heart failure
• severe valvular illness
• pulmonary disease
• uncontrolled hypertension
• kidney failure
• orthopaedic/neurological limitations
• cardiomyopathy
• planned operations during the research period
• participation in a parallel study

Sponsors & Collaborators

• Norwegian University of Science and Technology: lead

Study Sites (1)

Department of Circulation and Medical Imaging

Trondheim, 7491, Norway

Location

MeSH Terms

Conditions

Overweight; Obesity

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Øystein Risa

  Norwegian University of Science and Technology

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The study will consist of both a crossover study model (acute phase) and parallel model (chronic phase).

Study Record Dates

• First Submitted: September 20, 2021
• First Posted: October 25, 2021
• Study Start: October 14, 2021
• Primary Completion: February 28, 2022
• Study Completion: February 28, 2022
• Last Updated: May 26, 2022

Record last verified: 2022-05

Data Sharing

• IPD Sharing: Will not share

Locations

NO (1)