EXerCise wEight Loss

NCT05702840 | Completed

• 1 other identifier: EXerCise wEight Loss Study
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

The overall aim of this study is to investigate the effects of home-based resistance exercise programme on changes in body composition and strength during weight loss, in people living with obesity or overweight.

Conditions

Overweight and Obesity

Outcome Measures

Primary Outcomes (1)

• Change in whole body lean mass

  whole body lean mass measured via bio-electrical impedance

  Change from baseline to 12 weeks

Secondary Outcomes (6)

• Change in whole body fat mass

  Change from baseline to 12 weeks

• Change in body mass

  Change from baseline to 12 weeks

• Change in vastus lateralis muscle thickness

  Change from baseline to 12 weeks

• Change in knee extensor maximal isometric torque

  Change from baseline to 12 weeks

• Change in grip strength

  Change from baseline to 12 weeks

Study Arms (2)

Resistance exercise training + weight loss group (RT+WL)

EXPERIMENTAL

Participants (WL-RT) will be provided with a resistance exercise booklet containing instructions for exercises and links to demonstration videos. A demonstration and explanation of the exercises will be given at the beginning of the intervention, alongside a discussion of the principles of the programme such as starting level and progression. We will ask participants to perform the resistance exercises for 12-week period. Participants will be asked to perform exercises 3 times a week (3 sets reaching the RPE scale between 8 - 10 out of 10 (4-6 out of 10 in the first week)) for the intervention period. The exercises will include press-ups, band lateral raises, band seated low row, squat, lunge and calf raise.

Behavioral: Resistance exercise training + weight loss group

Weight loss only group (WL)

EXPERIMENTAL

All participants (WL and WL-RT) will be provided with vouchers to access the weight watchers weight loss programme for a 12-week period. Weight Watchers is a commercially available programme and participants will set an initial goal to lose 5kg of body mass. If 5kg weight loss is achieved then the participant can chose further weight loss goals, as long as it would result in a body mass in the weight watchers healthy weight range (https://www.weightwatchers.com/uk/weight-loss/programme/tools/healthy-weight-chart).This plan works on the basis of an individualised points plan that can then be used by the participant to select foods/meals to consume throughout the day.

Behavioral: Weight loss only group (WL)

Interventions

Resistance exercise training + weight loss group BEHAVIORAL

Doing resistance exercises as well as following the weight watchers weight loss programme for a 12-week period

Resistance exercise training + weight loss group (RT+WL)

Weight loss only group (WL) BEHAVIORAL

Only following the weight watchers weight loss programme for a 12-week period

Weight loss only group (WL)

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Obesity or overweight (BMI ≥ 25kg/m2).
• Passing the Physical Activity Readiness Questionnaire (PAR-q+)

You may not qualify if:

• Currently take part in more than 1.5 hours of structured exercise per week.
• Having recently (\<6 months) taken part in any resistance exercise training, taking any medications known to affect weight loss.
• Actively engaged in a weight loss programme, having lost more than 2kg weight in the last 6 months.
• Any other reason which would limit ability to perform the exercises and outcome measurements safely.

Sponsors & Collaborators

• University of Glasgow: lead

Study Sites (1)

Stuart Robert Gray

Glasgow, United Kingdom

Location

Related Publications (18)

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• Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, Rodrigues AM, Rehackova L, Adamson AJ, Sniehotta FF, Mathers JC, Ross HM, McIlvenna Y, Stefanetti R, Trenell M, Welsh P, Kean S, Ford I, McConnachie A, Sattar N, Taylor R. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet. 2018 Feb 10;391(10120):541-551. doi: 10.1016/S0140-6736(17)33102-1. Epub 2017 Dec 5.

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• Pellegrini M, Cioffi I, Evangelista A, Ponzo V, Goitre I, Ciccone G, Ghigo E, Bo S. Effects of time-restricted feeding on body weight and metabolism. A systematic review and meta-analysis. Rev Endocr Metab Disord. 2020 Mar;21(1):17-33. doi: 10.1007/s11154-019-09524-w.

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• Wolfe RR. The underappreciated role of muscle in health and disease. Am J Clin Nutr. 2006 Sep;84(3):475-82. doi: 10.1093/ajcn/84.3.475.

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• Sajoux I, Lorenzo PM, Gomez-Arbelaez D, Zulet MA, Abete I, Castro AI, Baltar J, Portillo MP, Tinahones FJ, Martinez JA, Crujeiras AB, Casanueva FF. Effect of a Very-Low-Calorie Ketogenic Diet on Circulating Myokine Levels Compared with the Effect of Bariatric Surgery or a Low-Calorie Diet in Patients with Obesity. Nutrients. 2019 Oct 4;11(10):2368. doi: 10.3390/nu11102368.

  PMID: 31590286 BACKGROUND

• Ashton RE, Tew GA, Aning JJ, Gilbert SE, Lewis L, Saxton JM. Effects of short-term, medium-term and long-term resistance exercise training on cardiometabolic health outcomes in adults: systematic review with meta-analysis. Br J Sports Med. 2020 Mar;54(6):341-348. doi: 10.1136/bjsports-2017-098970. Epub 2018 Jun 22.

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• Plotnikoff RC, Eves N, Jung M, Sigal RJ, Padwal R, Karunamuni N. Multicomponent, home-based resistance training for obese adults with type 2 diabetes: a randomized controlled trial. Int J Obes (Lond). 2010 Dec;34(12):1733-41. doi: 10.1038/ijo.2010.109. Epub 2010 Jun 8.

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• NIH Consensus statement. Bioelectrical impedance analysis in body composition measurement. National Institutes of Health Technology Assessment Conference Statement. December 12-14, 1994. Nutrition. 1996 Nov-Dec;12(11-12):749-62.

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• Binmahfoz A, Johnston L, Dunning E, Gray CM, Gray SR. The effects of a home-based resistance training programme on body composition and muscle function during weight loss in people living with overweight or obesity: a randomised controlled pilot trial. Nutr Metab (Lond). 2025 Aug 4;22(1):90. doi: 10.1186/s12986-025-00986-1.

  PMID: 40760444 DERIVED

MeSH Terms

Conditions

Overweight; Obesity

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Members of the research team that perform measurements are blinded to group allocation.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Randomised controlled pilot trial with two groups, resistance exercise + weight loss group and weight loss only group.

Study Record Dates

• First Submitted: January 18, 2023
• First Posted: January 27, 2023
• Study Start: February 1, 2023
• Primary Completion: February 1, 2024
• Study Completion: February 1, 2024
• Last Updated: February 28, 2024

Record last verified: 2024-02

Locations

GB (1)