The Role of Genetic Factors in the Development of Atopic Dermatitis in the Kazakh Population

NCT05090631 | Completed

• 1 other identifier: 1196
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

This is a GWAS study that aims to identify possible candidate genes associate to atopic dermatitisby exploring single nucleotide polymorphism (SNP) in a group of atopic dermatitis, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with atopic dermatitis

Conditions

Atopic Dermatitis

Keywords

GWAS

Outcome Measures

Primary Outcomes (1)

• number of SNPs associated with atopic dermatitis

  Using GWAS to identify candidate genes associate with atopic dermatitis

  1 year

Study Arms (2)

Experimental group:

Patients with atopic dermatitis

Genetic: DNA analysis

Control group

Patients without atopic dermatitis

Genetic: DNA analysis

Interventions

DNA analysis GENETIC

GWAS

Control group; Experimental group:

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

KAZAKH POPULATION

You may qualify if:

• Persons with various forms of a confirmed diagnosis of atopic dermatitis;
• The age of the patients is from 18 to 45+ years;
• Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs.
• Persons who are able and willing to provide written informed consent;
• Persons capable and willing to comply with the research protocol;

You may not qualify if:

• Persons under the age of 18;
• Patients with severe concomitant systemic diseases, including cardiovascular, respiratory, hepatic and renal failure
• Patients with severe infectious processes (sepsis, abscess, hepatitis B and C, HIV)
• Persons with mental illness.
• Persons taking corticosteroid drugs, immunosuppressants within the last month;
• Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
• Pregnant or lactating women;
• Tuberculosis of any localization in the active phase and in history;
• Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
• Severe and decompensated course of endocrine diseases;
• Autoimmune diseases;
• Systemic diseases;
• Oncological diseases;

Sponsors & Collaborators

• Asfendiyarov Kazakh National Medical University: lead

Study Sites (1)

Kazakhstan

Almaty, 050020, Kazakhstan

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood

MeSH Terms

Conditions

Dermatitis, Atopic

Condition Hierarchy (Ancestors)

Skin Diseases, Genetic; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Dermatitis; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Eczematous; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Gulya Sarybaeva, PhD

  Asfendiyarov Kazakh National Medical University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of the Laboratory of Experimental Medicine

Study Record Dates

• First Submitted: September 25, 2021
• First Posted: October 25, 2021
• Study Start: October 23, 2021
• Primary Completion: January 20, 2023
• Study Completion: January 20, 2023
• Last Updated: March 14, 2023

Record last verified: 2023-03

Locations

KA (1)