The Role of Genetic Factors in the Development of Myocardial Infarction in the Kazakh Population

NCT05090618 | Completed

• 1 other identifier: 1187
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

This is a GWAS study that aims to identify possible candidate genes associate to heart attack by exploring single nucleotide polymorphism (SNP) in a group of heart attack, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with heart attack

Conditions

Heart Attack

Keywords

GWAS

Outcome Measures

Primary Outcomes (1)

• number of SNPs associated with Heart Attack

  Using GWAS to identify candidate genes associate with Heart Attack

  1 year

Study Arms (2)

Experimental group:

Patients with Heart Attack

Genetic: DNA analysis

Control group

Patients without Heart Attack

Genetic: DNA analysis

Interventions

DNA analysis GENETIC

GWAS

Control group; Experimental group:

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

KAZAKH POPULATION

You may qualify if:

• Persons of Kazakh nationality
• Age up to 59 years inclusive at the time of primary myocardial infarction
• Myocardial infarction was established in accordance with the EOC criteria: An increase and / or decrease in the level of cardiac troponin must be combined with at least one of the following: • Symptoms of myocardial ischemia • Newly occurring ischemic changes on the ECG • The appearance of a pathological Q wave • Identification according to imaging data methods of new areas of non-viable myocardium, or new areas of local contractility disorders of presumably ischemic etiology • Detection of a thrombus in the coronary arteries according to coronary angiography
• Presence of coronary angiography
• Persons able and willing to provide written informed consent;

You may not qualify if:

• Age at primary myocardial infarction 60 years and older
• Heart defects, congenital and acquired
• Non-ischemic cardiomyopathies
• Autoimmune diseases
• Diabetes mellitus at the time of development of primary myocardial infarction
• Terminal stages of renal and hepatic failure

Sponsors & Collaborators

• Asfendiyarov Kazakh National Medical University: lead

Study Sites (1)

Kazakhstan

Almaty, 050020, Kazakhstan

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood

MeSH Terms

Conditions

Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Aisulu Mussagaliyeva, PhD

  Research Institute of Cardiology and Internal Medicine

  STUDY DIRECTOR

• Roza Kuanyshbekova

  Research Institute of Cardiology and Internal Medicine

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of the Laboratory of Experimental Medicine

Study Record Dates

• First Submitted: September 25, 2021
• First Posted: October 25, 2021
• Study Start: October 23, 2021
• Primary Completion: January 20, 2023
• Study Completion: January 20, 2023
• Last Updated: March 14, 2023

Record last verified: 2023-03

Locations

KA (1)