The Role of Genetic Factors in the Development of Arterial Hypertension in the Kazakh Population

NCT05088486 | Completed

• 1 other identifier: 1193
• Study Type: observational
• Target: 1,200
• Locations: 1 country
• Sites: 1

Brief Summary

This is a GWAS study that aims to identify possible candidate genes associate to arterial hypertension by exploring single nucleotide polymorphism (SNP) in a group of arterial hypertension, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with arterial hypertension

Conditions

Arterial Hypertension

Keywords

GWAS

Outcome Measures

Primary Outcomes (1)

• number of SNPs associated with arterial hypertension

  Using GWAS to identify candidate genes associate with arterial hypertension

  1 year

Study Arms (2)

Experimental group:

Patients with arterial hypertension

Genetic: DNA analysis

Control group

Patients without arterial hypertension

Genetic: DNA analysis

Interventions

DNA analysis GENETIC

GWAS

Control group; Experimental group:

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

patients with arterial hypertension of Kazakh nationality

You may qualify if:

• Persons with confirmed arterial hypertension;
• The age of patients is from 18 to 55 years old inclusive;
• Persons of Kazakh nationality, whose paternal and maternal grandparents identify themselves as Kazakhs;
• Persons who are able and willing to provide written informed consent;
• Persons capable and willing to comply with the research protocol;

You may not qualify if:

• Persons under 18 and over 55;
• Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
• Pregnant or lactating women;
• Tuberculosis of any localization in the active phase and in history;
• Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
• Severe and decompensated course of endocrine diseases;
• Autoimmune diseases;
• Systemic diseases;
• Cancer.

Sponsors & Collaborators

• Asfendiyarov Kazakh National Medical University: lead

Study Sites (1)

Deputy head of Gerontology Center of Medical Centre Hospital of the President's Affairs Administration of the Republic of Kazakhstan

Almaty, Kazakhstan

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Officials

• Raushan Karibayeva, Doctor of medical sciences

  Deputy head of Gerontology Center of Medical Centre Hospital of the President's Affairs Administration of the Republic of Kazakhstan

  STUDY DIRECTOR

• Tamara Vochshenkova, MBA

  Deputy head of Gerontology Center of Medical Centre Hospital of the President's Affairs Administration of the Republic of Kazakhstan

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of the Laboratory of Experimental Medicine

Study Record Dates

• First Submitted: September 25, 2021
• First Posted: October 22, 2021
• Study Start: March 30, 2022
• Primary Completion: January 20, 2023
• Study Completion: January 20, 2023
• Last Updated: March 14, 2023

Record last verified: 2023-03

Locations

KA (1)