Assessment of Ultrasonographic Measurement of Inferior Vena Cava Collapsibility Index in Prediction of Hypotension Associated With Tourniquet Release in Total Knee Replacement Surgeries Under Spinal Anesthesia

NCT05076929 | Completed

• 1 other identifier: MS 292/ 2021
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Administration of intravascular fluids is one of the methods to prevent SA-induced hypotension, but empirical intraoperative volume repletion carries the risk of fluid overload during elective surgery. Over fluid resuscitation is associated with organ dysfunction and higher mortality rate , thus, to avoid ineffective or even harmful intravascular volume expansion, it is important to have tools to predict hypotension and fluid responsiveness.

Conditions

Fluid Hypovolemia, Cerebrospinal

Outcome Measures

Primary Outcomes (1)

• mean arterial blood pressure

  15 minutes after tourniquet release

Interventions

ultrasound DIAGNOSTIC_TEST

Ultrasonographic measurement of Inferior Vena Cava Collapsibility Index

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Total Knee Replacement Surgeries under Spinal Anesthesia

You may qualify if:

• ASA grade I, II, III
• Age 18 -65 yrs
• Spinal Anesthesia

You may not qualify if:

• Patient refusal
• Patient having contraindication of Spinal Anesthesia (infection at the site of injection, spine deformity, coagulation disorders ) .
• Known cardiac, renal, neurological, metabolic, endocrine, psychiatric, respiratory disease.

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain Shams University

Cairo, Egypt

Location

MeSH Terms

Conditions

Intracranial Hypotension

Interventions

Ultrasonography

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: September 26, 2021
• First Posted: October 13, 2021
• Study Start: May 28, 2021
• Primary Completion: February 1, 2022
• Study Completion: March 1, 2022
• Last Updated: October 3, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)