Epidemiological Study in FRONtoTemporal Dementia
EFRONT
1 other identifier
observational
2,287
7 countries
37
Brief Summary
An international, multicenter, epidemiological observational study aims to investigate the prevalence of genetic etiologies in patients diagnosed with FTD or clinically suspected for FTD.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2021
Typical duration for all trials
37 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2021
CompletedFirst Submitted
Initial submission to the registry
September 30, 2021
CompletedFirst Posted
Study publicly available on registry
October 12, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 9, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
January 9, 2024
CompletedApril 9, 2026
April 1, 2026
2.4 years
September 30, 2021
April 7, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
To investigate the prevalence of genetic etiologies in FTD by genotyping FTD participants/ FTD suspected participants
15 months
Study Arms (1)
Participants diagnosed with Frontotemporal Dementia
Participants diagnosed with Frontotemporal Dementia
Interventions
Blood samples will be collected from clinically diagnosed or suspected FTD patients and will be analysed for a broad range of pathogenic variants in genes associated with FTD.
Eligibility Criteria
Participants diagnosed with Frontotemporal Dementia (FTD) and participants clinically suspected for FTD
You may qualify if:
- Informed consent, which includes reference to the genetic testing, is obtained from the participant/legal guardian
- The participant is aged between 25 to 85 years
- The participant is diagnosed with Frontotemporal dementia (FTD) or has signs or symptoms of FTD
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (37)
AZ Damiaan
Ostend, West Flanders, 8400, Belgium
CHU de Liege
Liège, 4000, Belgium
Hanau Hospital
Hanau, Hesse, 63450, Germany
Gertrudis Klinik
Leun, Hesse, 35638, Germany
University Hospital Dresden
Dresden, Saxony, 01307, Germany
University Medical Center Hamburg Eppendorf
Hamburg, Schleswig-Holstein, 20246, Germany
University of Lübeck
Lübeck, Schleswig-Holstein, 23562, Germany
RWTH Aachen University
Aachen, 52074, Germany
Hochtaunus-Kliniken gGmbH
Bad Homburg, 61352, Germany
AGZ of Charite Universitätsmedizin Berlin
Berlin, 12200, Germany
University Hospital Cologne
Cologne, 50937, Germany
Asklepios Klinik Nord - Ochsenzoll
Hamburg, 22419, Germany
University Hospital Rostock
Rostock, 18057, Germany
Mediterraneo Hospital
Athens, 16675, Greece
University of Ioannina
Ioannina, 45110, Greece
Università degli studi Gabriele D'Annunzio Chieti-Pescara
Chieti, 66100, Italy
Azienda Ospedaliera Universitaria Federico II di Napoli
Naples, 80131, Italy
Azienda Ospedaliero-Universitaria di Parma
Parma, 43126, Italy
Azienda USL-IRCCS of Reggio Emilia
Reggio Emilia, 42121, Italy
Hospital Garcia de Orta
Almada, 2805-267, Portugal
Unidade Psiquiatrica Privada de Coimbra
Coimbra, 3000-606, Portugal
Hospital da Senhora da Oliveira Guimaraes
Guimarães, 4835-044, Portugal
Hospital Beatriz Ângelo
Loures, 2674-514, Portugal
Hospital Pedro Hispano
Matosinhos Municipality, 4464-513, Portugal
CNS - campus neurológico Torres Vedras
Torres Vedras, 2560-280, Portugal
Hospital Universitari vall D´hebron
Barcelona, 08035, Spain
Universitary Hospital La Princesa
Madrid, 28006, Spain
Hospital Clinico San Carlos
Madrid, 28040, Spain
Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
Clinica Universidad de Navarra
Pamplona, 31008, Spain
Marqués de Valdecilla University Hospital
Santander, 39011, Spain
Baskent University
Ankara, 06100, Turkey (Türkiye)
Hacettepe University
Ankara, 06100, Turkey (Türkiye)
Koç University Hospital
Istanbul, 34010, Turkey (Türkiye)
Istanbul University
Istanbul, 34080, Turkey (Türkiye)
Bezmialem Vakif University
Istanbul, 34093, Turkey (Türkiye)
Izmir Economy University Medikalpark Hospital
Izmir, 35575, Turkey (Türkiye)
Biospecimen
Blood sample applied on the Dry Blood Spot (DBS) Filtercard (Centocard®)
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Peter Bauer, Ph.D
Centogene GmbH
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 30, 2021
First Posted
October 12, 2021
Study Start
September 1, 2021
Primary Completion
January 9, 2024
Study Completion
January 9, 2024
Last Updated
April 9, 2026
Record last verified: 2026-04