Intake Duration Effects of Blackcurrant on Cardiovascular and Metabolic Responses

NCT05067062 | Completed

• 1 other identifier: MW1718NZBCduration
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Study will examine the metabolic, physiological and cardiovascular changes by intake of New Zealand blackcurrant extract at rest and during moderate-intensity treadmill walking in healthy males.

Conditions

no Conditions

Outcome Measures

Primary Outcomes (5)

• Changes in heart rate from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract

  The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Heart rate will be measured in beats/min.

  baseline, acute, one week and two weeks

• Changes in stroke volume from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract

  The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Stroke volume will be measured in mL.

  baseline, acute, one week and two weeks

• Changes in cardiac output from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract

  The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Cardiac output will be measured in L/min.

  baseline, acute, one week and two weeks

• Changes in blood pressure from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract

  The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Systolic, diastolic and mean arterial blood pressure will be measured in mmHg.

  baseline, acute, one week and two weeks

• Changes in total peripheral resistance from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract

  The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Total peripheral resistance will be measured in (mmHg·min)/L

  baseline, acute, one week and two weeks

Secondary Outcomes (5)

• Changes in oxygen consumption from baseline with acute intake, one week and two weeks intake.

  baseline, acute, one week and two weeks

• Changes in carbon dioxide production from baseline with acute intake, one week and two weeks intake.

  baseline, acute, one week and two weeks

• Changes in respiratory exchange ratio from baseline with acute intake, one week and two weeks intake.

  baseline, acute, one week and two weeks

• Changes in carbohydrate oxidation from baseline with acute intake, one week and two weeks intake.

  baseline, acute, one week and two weeks

• Changes in fat oxidation from baseline with acute intake, one week and two weeks intake.

  baseline, acute, one week and two weeks

Study Arms (2)

new zealand blackcurrant extract

ACTIVE COMPARATOR

Capsules will be take daily or every other day.

Dietary Supplement: New Zealand blackcurrant extract

control

PLACEBO COMPARATOR

no capsules will be provided.

Dietary Supplement: New Zealand blackcurrant extract

Interventions

New Zealand blackcurrant extract DIETARY_SUPPLEMENT

Capsules taken daily or intermittent

control; new zealand blackcurrant extract

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy
• Non-smokers
• Not taking any supplements
• No known allergy to berries or berry products

You may not qualify if:

• Sedentary
• Known high blood pressure
• Smoking
• On medication

Sponsors & Collaborators

• University of Chichester: lead

Study Sites (1)

Mark Willems

Chichester, West Sussex, PO19 6PE, United Kingdom

Location

Related Publications (2)

• Sahin PhD MA, Bilgic PhD P, Montanari MSc S, Willems PhD MET. Intake Duration of Anthocyanin-Rich New Zealand Blackcurrant Extract Affects Metabolic Responses during Moderate Intensity Walking Exercise in Adult Males. J Diet Suppl. 2021;18(4):406-417. doi: 10.1080/19390211.2020.1783421. Epub 2020 Jun 24.

  PMID: 32578472 BACKGROUND

• Sahin PhD MA, Bilgic PhD P, Montanari MSc S, Willems PhD MET. Daily and Not Every-Other-Day Intake of Anthocyanin-Rich New Zealand Blackcurrant Extract Alters Substrate Oxidation during Moderate-Intensity Walking in Adult Males. J Diet Suppl. 2022;19(1):49-61. doi: 10.1080/19390211.2020.1841356. Epub 2020 Oct 29.

  PMID: 33118421 RESULT

Study Officials

• Mark E Willems, PhD

  University of Chichester

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Exercise Physiology

Study Record Dates

• First Submitted: September 10, 2021
• First Posted: October 4, 2021
• Study Start: September 1, 2017
• Primary Completion: September 1, 2018
• Study Completion: September 1, 2018
• Last Updated: October 4, 2021

Record last verified: 2021-10

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)