Validation of a Predictive Rule for the Diagnosis of Viral Meningitis in Adult Emergency Departments

NCT05062642 | Unknown

• 1 other identifier: CHM-2020/S02/20
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

Meningitis is the development of an inflammatory reaction in the meningeal space, most often of infectious origin. Many pathogens can cause meningitis, the severity of which varies greatly. Patients presenting with a febrile meningeal syndrome are most often managed in the emergency room, where the challenge for physicians is to quickly differentiate bacterial and viral meningitis. Viral meningitis is the most common, with enterovirus meningitis having a classically excellent prognosis. Bacterial meningitis is less frequent but more serious.The current public health objective is to save antibiotics. Investigator hypothesizes that the BMS score can be used to exclude bacterial meningitis in the emergency department in an adult European population of patients with suspected bacterial meningitis.

Conditions

Meningitis

Keywords

BMS score; Meningitis

Outcome Measures

Primary Outcomes (1)

• External validation of the BMS score in a European adult population to exclude bacterial meningitis

  Validation was measured by comparaison between BMS score and the diagnosis retained from the data collected in the file

  1 month after inclusion

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will be extracted from the population having consulted the Adult Emergency Departments of the Le Mans Hospital, the Angers and Nantes University Hospitals and the Beaujon University Hospital between January 1, 2009 and December 31, 2020 and for whom a lumbar puncture will have been performed for suspected meningitis.

You may qualify if:

• Patient admitted to the Adult Emergency Department of CH Le Mans,CHU Angers, CHU Nantes or Beaujon Hospital.
• Over 18 years old
• Having had a lumbar puncture during their stay in the Adult Emergency Department
• Having had a diagnosis of meningitis defined as a pleocytosis ≥ 5leukocytes/mm3 after correction with CSF red blood cells at a standardized ratio of 500/1.

You may not qualify if:

• Immunosuppression from any cause
• Presence of petechiae or purpura
• History of recent neurosurgery or head trauma
• Other associated bacterial infection
• Inability to collect information for the BMS score calculation or primary endpoint (e.g., transfer to another facility)
• Minor or adult patient under guardianship or protection

Sponsors & Collaborators

• Centre Hospitalier le Mans: lead

Study Sites (1)

Centre Hospitalier Du Mans

Le Mans, 72000, France

RECRUITING

MeSH Terms

Conditions

Meningitis

Condition Hierarchy (Ancestors)

Neuroinflammatory Diseases; Nervous System Diseases

Central Study Contacts

Christelle JADEAU

CONTACT

02 44 71 07 81; cjadeau@ch-lemans.fr

Jean-Christophe CALLAHAN, MD

CONTACT

02 43 43 43 43; jccallahan@ch-lemans.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 21, 2021
• First Posted: September 30, 2021
• Study Start: August 26, 2021
• Primary Completion: August 26, 2022
• Study Completion: August 26, 2022
• Last Updated: January 24, 2022

Record last verified: 2021-09

Locations

FR (1)