Epidemiological, Clinical, Microbiological and Outcome Description of Patients With Klebsiella sp Meningitis
KlebsieLCR
1 other identifier
observational
132
1 country
18
Brief Summary
Klebsiella pneumoniae is implicated in the occurrence of severe pneumonia. Most Klebsiella pneumoniae infections are associated with care and occur in patients with compromised immune defenses. More recently, cases of hepatic abscess and acute community meningitis related to strains of Klebsiella pneumoniae have been reported. The mortality of these infections is important, most often due to a delayed diagnosis. The poor prognostic factors reported in the literature for very low numbers are: advanced age, coma, septic shock, glyceryachia \<10mg / dL and proteinuria\> 750 mg / dL. In addition, no study has specifically focused on the factors of occurrence and factors associated with Klebsiella sp. Indeed, meningitis related to Klebsiella pneumoniae seems to be a rare but probably underestimated event whose risk factors, clinical presentation, microbiological are little known and the treatment modalities of this severe infection are not codified.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jul 2019
Shorter than P25 for all trials
18 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 24, 2019
CompletedFirst Posted
Study publicly available on registry
May 30, 2019
CompletedStudy Start
First participant enrolled
July 5, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
January 13, 2020
CompletedAugust 23, 2021
August 1, 2021
6 months
May 24, 2019
August 20, 2021
Conditions
Outcome Measures
Primary Outcomes (1)
Characterize meningitis with Klebsiella pneumoniae
This corresponds to characterize Klebsiella pneumoniae meningitis, portal entry, secondary infection, associated antibiotic and associated therapies and the clinical course of patients.
Day 1
Eligibility Criteria
Patient with meningitis Klebsiella sp., hospitalized in one of the hospitals of the Clinical Microbiology Group between 2008 and 2018.
You may qualify if:
- Man or Woman whose age ≥ 18 years
- Patient with meningitis Klebsiella sp., hospitalized in one of the hospitals of the Clinical Microbiology Group
- Francophone patient
You may not qualify if:
- Patient under tutorship or curatorship
- Patient deprived of liberty
- Patient under safeguard of justice
- Patient opposing his participation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (18)
CHU Brest
Brest, France
CHU Caen
Caen, France
Hôpital henri Mondor
Créteil, France
CHU Lyon
Lyon, France
CHU Nantes
Nantes, 44093, France
CHU Nice
Nice, France
Hôpital Lariboisière
Paris, 75010, France
Groupe Hospitalier Paris Saint-Joseph
Paris, 75014, France
Hôpital Cochin
Paris, 75014, France
CHU Kremlin Bicetre
Paris, France
Hôpital Foch
Paris, France
Hôpital Necker Enfants Malades
Paris, France
Hôpital Sainte Anne
Paris, France
CHU Poitiers
Poitiers, 86000, France
CHU Reims
Reims, France
CHU Rennes
Rennes, 35000, France
CHU Strasbourg
Strasbourg, 67000, France
CHU Tours
Tours, France
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Benoit PILMIS, MD
Fondation Hôpital Saint-Joseph
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 24, 2019
First Posted
May 30, 2019
Study Start
July 5, 2019
Primary Completion
December 31, 2019
Study Completion
January 13, 2020
Last Updated
August 23, 2021
Record last verified: 2021-08