Improving the Diagnosis of Meningitis in Emergency Rooms

NCT02858661 | Completed

• 1 other identifier: 2012-45
• Study Type: interventional
• Target: 109
• Locations: 1 country
• Sites: 1

Brief Summary

A point-of-care laboratory (POC) was set at North Hospital, Marseille, France for the diagnosis in less than two hours of meningitis caused by known pathogens, close to the reception of Emergency service. In this instance 30% of patients have no etiological diagnosis after the POC diarrhoea tests . This lab has discovered over 200 new species of bacteria in humans, including vector bacteria and opened the field of large Deoxyribonucleic Acid (DNA ) viruses. Also, the laboratory of emerging viruses discovered many Ribonucleic Acid (RNA) viruses transmitted by arthropods. Based on this collection of new pathogens described in POC laboratory, this study proposes to expand the etiological diagnosis strategy of meningitis after POC test.

Conditions

Meningitis

Outcome Measures

Primary Outcomes (1)

• Percentage of patients admitted with a meningitis with a confirmed etiological diagnosis

  1 day

Study Arms (1)

Patients diagnosed with clinical meningitis

EXPERIMENTAL

Patients admitted in emergency rooms for clinical meningitis, for which a nasopharyngeal swab will be performed in order to confirm the etiological diagnosis of meningitis

Other: Nasopharyngeal swab

Interventions

Nasopharyngeal swab OTHER

Patients diagnosed with clinical meningitis

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient admitted at hospital for meningitis requiring, for the emergency physician, a microbiological examination with a "POC meningitis kit."
• Patient who has freely signed the informed written consent
• Patient affiliated to a social security scheme

You may not qualify if:

• Pregnant woman, parturient or nursing
• Adult patient under guardianship
• Patient deprived of liberty under court order
• Patient refusing or unable to sign the informed consent form.

Sponsors & Collaborators

• Assistance Publique Hopitaux De Marseille: lead

Study Sites (1)

Assistance Publique Hopitaux de Marseille

Marseille, 13354, France

Location

MeSH Terms

Conditions

Meningitis

Condition Hierarchy (Ancestors)

Neuroinflammatory Diseases; Nervous System Diseases

Study Officials

• Catherine GEINDRE

  Assistance Publique Hôpitaux de Marseille

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 29, 2016
• First Posted: August 8, 2016
• Study Start: March 30, 2013
• Primary Completion: February 8, 2019
• Study Completion: October 27, 2022
• Last Updated: April 21, 2023

Record last verified: 2023-04

Locations

FR (1)