Effects of Concurrent Exercise Combinations in Knee Osteoarthritis:

NCT05054686 | Completed DMC

• 1 other identifier: IstanbulUCSEDA
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

This study will include 3 different groups of intervention. First group of knee osteoarthritis patients will be applied both strengthening and 30 minutes bicycle exercises in the same session, 2 days strecthing exercises and 30 minutes walking will be given in seperate days as home program, Second group of knee osteoarthritis patients will be applied both stretching and 30 minutes bicycle exercises in the same session, strengthening exercises and 30 minutes walking will be given in seperate days as home program.Third group of knee osteoarthritis patients will be applied all stretching, strengthening and 30 minutes bicycle exercises in the same session, only 30 minutes walking will be given as home program. The primary outcome measures include the pain, function and the secondary outcome measures include the joint proprioception. The aim of this study is to investigate the effects on outcome measures increasing number of exercises in one session and to determine which exercise types are more suitable to prescribe as a home program.

Conditions

Knee Osteoarthritis

Keywords

ostearthritis; pain; proprioception; resistance training; exercise

Outcome Measures

Primary Outcomes (3)

• The Western Ontario and McMaster Universities Arthritis Index

  The Western Ontario and McMaster Universities Arthritis Index is a questionnaire consisting of 24 items divided into 3 subscales: Pain (5 items): during walking, using stairs, in bed, sitting or lying, and standing upright Stiffness (2 items): after first waking and later in the day Physical Function (17 items): using stairs, rising from sitting, standing, bending, walking, getting in / out of a car, shopping, putting on / taking off socks, rising from bed, lying in bed, getting in / out of bath, sitting, getting on / off toilet, heavy domestic duties, light domestic duties. The increasing scores reflect improvement of the function.

  Change of The Western Ontario and McMaster Universities Arthritis Index scores from the beginning to the end of study (8 weeks)

• Numeric Pain Rating Scale

  The Numeric Pain Rating Scale is a segmented numeric version of the visual analog scale in which a respondent selects a whole number (0-10 likert type integers) that best reflects the intensity of his/her pain.The levels of pain felt at rest / activity / night will be evaluated. The increase in pain scores demonstrate that the health status get worse.

  Change of Numeric Pain Rating Scale scores from the beginning to the end of study (8 weeks)

• Pain Pressure Treshold (PPT)

  Pain Pressure Treshold is evaluated via algometric measurement that were taken from 4 point including the mid portion of patella, 3 cm medial to patellar midline, 3 cm lateral to patellar midline, 2 cm above to patellar upper boundary.The increase in algometric measurement demonstrate the development in the pain sensitivity.

  Change of Pain Pressure Treshold measurements from the beginning to the end of study (8 weeks)

Secondary Outcomes (2)

• Proprioception

  Change of Inclinometric measurements from the beginning to the end of study (8 weeks).

• Knee Muscle Strength

  Change of muscle strength measurements from the beginning to the end of study (8 weeks)

Study Arms (3)

Combination of Stretching and Aerobic Exercises at Clinic

EXPERIMENTAL

Combination of Stretching and Aerobic Exercises at Clinic and Strengthening and Aerobic Exercises at Home

Other: Stretching and Aerobic Exercise at Clinic

Combination of Strengthening and Aerobic Exercises at Clinic

ACTIVE COMPARATOR

Combination of Strengthening and Aerobic Exercises at Clinic and Stretching and Aerobic Exercises at Home

Other: Strenghthening and Aerobic Exercise

Combination of Strengthening, Stretching and Aerobic Exercises at Clinic

ACTIVE COMPARATOR

Combination of Strengthening, Stretching and Aerobic Exercises at Clinic and Aerobic Exercises at Home

Other: Strengthening, Stretching and Aerobic Exercises at clinic

Interventions

Stretching and Aerobic Exercise at Clinic OTHER

In this group of knee osteoarthritis patients will be applied both stretching and 30 minutes bicycle exercises in the same session, strengthening exercises and 30 minutes walking will be given in seperate days as home program.

Combination of Stretching and Aerobic Exercises at Clinic

Strenghthening and Aerobic Exercise OTHER

In this group of knee osteoarthritis patients will be applied both strengthening and 30 minutes bicycle exercises in the same session, 2 days strecthing exercises and 30 minutes walking will be given in seperate days as home program.

Combination of Strengthening and Aerobic Exercises at Clinic

Strengthening, Stretching and Aerobic Exercises at clinic OTHER

In this group of knee osteoarthritis patients will be applied all stretching, strengthening and 30 minutes bicycle exercises in the same session, only 30 minutes walking will be given as home program.

Combination of Strengthening, Stretching and Aerobic Exercises at Clinic

Eligibility Criteria

• Age: 45 Years - 73 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Being diagnosed as knee osteoarthritis
• Being between the ages 45-74
• Being at stage 2-3 according to Kellegren Lawrence Classification
• Having body mass index lower than 30
• Being volunteer for participation to this study

You may not qualify if:

• Refusing to participation to study
• Having another orthopeadic problem ralated to lower extremity
• Having uncontrollable hypertension
• Having arterial and venous disease
• Having neurological disease
• Having perceptual problem
• Having cardiac pacemaker
• Participation to physiotherapy program in the last 6 months for the same extremity
• Taking injection from the same extremity in the last 6 months

Sponsors & Collaborators

• Istanbul University - Cerrahpasa: lead

Study Sites (1)

Seda Baktır

Küçükçekmece, Alkent 2000, Büyükçekmece/İstanbul, 34307, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Osteoarthritis, Knee; Pain; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Seda BAKTIR, MSc.PT.

  Istanbul University - Cerrahpasa

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: Double Blind
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Prospective Randomized Controlled Parallel Group Study

Study Record Dates

• First Submitted: September 12, 2021
• First Posted: September 23, 2021
• Study Start: July 1, 2019
• Primary Completion: April 30, 2021
• Study Completion: May 30, 2021
• Last Updated: February 4, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)