Hop Compounds and Immune System
HI
Effect of Iso-alpha-Acids and Xanthohumol on Inflammatory Processes in Human
1 other identifier
interventional
15
1 country
1
Brief Summary
The aim of the present study is to determine the effect of Xanthohumol and Iso-alpha-acids from hops on the immune response of healthy participants.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jun 2019
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 13, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 27, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
January 27, 2021
CompletedFirst Submitted
Initial submission to the registry
March 16, 2021
CompletedFirst Posted
Study publicly available on registry
April 19, 2021
CompletedMarch 22, 2022
March 1, 2022
1.6 years
March 16, 2021
March 21, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Changes in parameters of immune response
Parameters of immune response are measured in cell culture supernatant of stimulated cells
5 days
Study Arms (4)
Placebo
EXPERIMENTALParticipants receive a study drink supplemented with a placebo over a time period of 5 days.
Xanthohumol
EXPERIMENTALParticipants receive a study drink supplemented with Xanthohumol over a time period of 5 days.
Iso-alpha acids
EXPERIMENTALParticipants receive a study drink supplemented with Iso-alpha acids over a time period of 5 days.
Xanthohumol/Iso-alpha acids
EXPERIMENTALParticipants receive a study drink supplemented with a combination of Xanthohumol and Iso-alpha acids over a time period of 5 days.
Interventions
Participants receive a study drink supplemented with a placebo for 5 days
Participants receive a study drink supplemented with xanthohumol, Iso-alpha acids or a combination of both for 5 days
Eligibility Criteria
You may qualify if:
- healthy, normal weight,
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Vienna
Vienna, 1090, Austria
Related Publications (2)
Jung F, Staltner R, Baumann A, Burger K, Halilbasic E, Hellerbrand C, Bergheim I. A Xanthohumol-Rich Hop Extract Diminishes Endotoxin-Induced Activation of TLR4 Signaling in Human Peripheral Blood Mononuclear Cells: A Study in Healthy Women. Int J Mol Sci. 2022 Oct 21;23(20):12702. doi: 10.3390/ijms232012702.
PMID: 36293555DERIVEDJung F, Staltner R, Tahir A, Baumann A, Burger K, Halilbasic E, Hellerbrand C, Bergheim I. Oral intake of xanthohumol attenuates lipoteichoic acid-induced inflammatory response in human PBMCs. Eur J Nutr. 2022 Dec;61(8):4155-4166. doi: 10.1007/s00394-022-02964-2. Epub 2022 Jul 20.
PMID: 35857130DERIVED
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
March 16, 2021
First Posted
April 19, 2021
Study Start
June 13, 2019
Primary Completion
January 27, 2021
Study Completion
January 27, 2021
Last Updated
March 22, 2022
Record last verified: 2022-03
Data Sharing
- IPD Sharing
- Will not share