Characterization of Suicidal Depression

NCT05046587 | Completed

• 1 other identifier: RECHMPL21_0395
• Study Type: observational
• Target: 898
• Locations: 1 country
• Sites: 1

Brief Summary

Antidepressants are widely used to prevent suicidal risk. However, even though the use of antidepressants has been associated with a 40-60% decrease in suicidal risk, they do not seem to be sufficient and appropriate. Indeed recent studies have shown that patients with a history of suicide attempt and/or with current suicidal ideation (SI) respond less well to antidepressant treatments. This suggests that patients with depression with SI may be different from those with depression without SI, thus requiring specific treatments for both SI reduction and depressive remission. In other words, suicidal depression may be a specific subtype of depression. The study aims to characterize the clinical phenotype of patients with suicidal depression vs. those without suicidal depression, and to assess the occurrence of suicidal events at one year in patients with suicidal depression vs. without suicidal depression. All data having already been collected during the particpation of patients in various clinical research studies of the department

Conditions

Depression

Keywords

Suicide; Suicidal Ideation; Suicidal Depression

Outcome Measures

Primary Outcomes (1)

• characterization of the patient clinical phenotype

  characterization of the patient clinical phenotype

  day 1

Secondary Outcomes (3)

• Suicidal events at one year

  1 year

• Hospitalization for suicidal ideation

  1 year

• Suicidal events at one year

  1 year

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Depressed patients with and without suicidal ideation, admitted to the Department of Emergency Psychiatry and Acute Care (Montpellier University Hospital) and enrolled in one of the department's clinical studies.

You may qualify if:

• Over 18 years old
• Hospitalization in the Department of Emergency Psychiatry and Acute Care (Montpellier University Hospital) between 2012 and 2019
• Having being enrolled in one the department's clinical studies between 2012 and 2019
• Moderate to severe characterized depressive episode according to DSM-5 diagnostic criteria (severity assessed with BDI, IDSC-30 and QIDS)

You may not qualify if:

• Protection by law (guardianship or curatorship)
• Deprivation of liberty (by judicial or administrative decision)
• Bipolar disorder

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

Uhmontpellier

Montpellier, 34295, France

Location

MeSH Terms

Conditions

Depression; Suicide; Suicidal Ideation

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior; Self-Injurious Behavior

Study Officials

• Bénédicte NOBILE, PharmD, PhD

  University Hospital, Montpellier

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 5, 2021
• First Posted: September 16, 2021
• Study Start: June 1, 2021
• Primary Completion: September 1, 2021
• Study Completion: September 30, 2021
• Last Updated: November 15, 2021

Record last verified: 2021-11

Locations

FR (1)