Perception of Music and Facial and Vocal Emotions in a Population With and Without Depression

NCT05143983 | Unknown DMC

• 1 other identifier: 2021-A01916-35
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Depressed subjects display a cognitive bias of information processing and emotional self-regulation, which reinforces negative experiences more than positive ones, known as the negativity bias. The link between depressive disorder and negativity bias has been much studied in terms of genetic, neurobiology, structural and functional neuroanatomy and cognitive sciences. It has been admitted that depressed subjects show impairment of facial expressions and prosody recognition, and of implicit memory. Induction of depressive or elated mood with musical excerpts listening in healthy subjects influences facial emotions perception, respectively by reducing or enhancing recognition skills. However, no study to date already explored the interest of music-induced positive mood for alleviating negativity bias in depressed elderly population. Main objective : to assess the impact of exposure to positive valence musical excerpts, on evaluation of facial emotions intensity, in a population of elderly patients hospitalized for depression, compared to neutral valence music listening. Secondary objectives : to assess the impact of exposure to positive valence musical excerpts, on facial and vocal emotions recognition, and on implicit memory of faces, compared to neutral valence music listening. The same methodology is also applied in a sample of control participants over 65 years to study the mood induction effect by music in elderlies.

Conditions

Depression

Keywords

music; depression; elderly; Emotion perception

Outcome Measures

Primary Outcomes (1)

• Emotional intensity score of facial expressions, rated by participants

  This intensity score will be calculated for a subject as the mean of intensity scores (from 1 to 5) attributed to negative faces and reverse intensity scores attributed to positive faces. This will give a "negativity score". The higher this score, the more negative emotions are judged as intense and the less positive emotions are judged as intense. This measurement will be collected by a computerized interface in two different sessions, one for each experimental condition.

  up to 9 days

Secondary Outcomes (2)

• Emotions recognition

  up to 7 days

• Implicit memory

  1 day

Study Arms (4)

depressed subjects, positive valence music listening at first

ACTIVE COMPARATOR

patients with major depressive disorder will be recruited and will complete 3 cognitive tasks after listening to positive musical excepts (3 minutes)

Behavioral: Positive valence music

depressed subjects, neutral valence music listening

OTHER

patients with major depressive disorder will be recruited and will complete 3 cognitive tasks after listening to neutral valence musical excepts (3 minutes)

Behavioral: Neutral valence music

healthy controls, positive valence music listening

OTHER

healthy individuals will be recruited and will complete 3 cognitive task after listening to positive valence musical excepts (3 minutes)

Behavioral: Positive valence music

healthy controls, neutral valence music listening

OTHER

healthy individuals will be recruited and will complete 3 cognitive task after listening to neutral valence musical excepts (3 minutes)

Behavioral: Neutral valence music

Interventions

Positive valence music BEHAVIORAL

Subjects will have to listen to 3 minutes of unfamiliar musical excerpts, with positive valence characteristics (fast tempo, major key). They will be told to listen carefully in order to then answer a short questionnaire. The listening will be followed by an liking scale (from 1 : not liked at all, to 5 : liked a lot) and a familiarity scale (from 1 : not familiar at all, to 5 : very familiar).

depressed subjects, positive valence music listening at first; healthy controls, positive valence music listening

Neutral valence music BEHAVIORAL

Subjects will have to listen to 3 minutes of unfamiliar musical excepts with neutral valence. They will be told to listen carefully in order to then answer to a short questionnaire. The listening will be followed by a liking scale (from 1 : not liked at all, to 5 : liked a lot) and a familiarity scale (from 1 : not familiar at all, to 5 : very familiar).

depressed subjects, neutral valence music listening; healthy controls, neutral valence music listening

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Men and Women between the ages of 18 and 60 years old
• Major depressive episode of moderate to strong intensity, according to DSM-5 criteria, diagnosed by a Psychiatrist for subjects with depression ; GDS \< 5 for healthy subjects
• Being fluent in French

You may not qualify if:

• \- Neurodegenerative disorder
• Cognitive impairments (MMSE\<26)
• Sensory loss not sufficiently corrected, compromising the perception of oral instructions or visual or auditory stimuli
• Impairment of awareness or attentional abilities restricting completion of cognitive tasks lasting 40 minutes.
• And for Patients with depressive episode:
• Psychotic or catatonic features of current depressive episode
• Comorbid psychiatric disorder other than major unipolar depressive or anxiety disorders
• Current treatment by electroconvulsive therapy

Sponsors & Collaborators

• Hôpital le Vinatier: lead

Study Sites (1)

Centre Hospitalier Le Vinatier

Bron, 69678, France

RECRUITING

MeSH Terms

Conditions

Depression

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior

Study Officials

• Jean-Michel DOREY, MD, PHD

  CH le Vinatier

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jean-Michel DOREY, MD,PHD

CONTACT

0437915531; jean-michel.dorey@ch-le-vinatier.fr

Lydie SARTELET

CONTACT

+33437915531; lydie.sartelet@ch-le-vinatier.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Subjects masked from the study hypothesis.
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Two groups of participants will be recruited: depressed patients and healthy controls. Each of these groups will be divided in two arms: one group listening to positive music at the first testing visit and neutral music at the second one, and the other group being exposed to positive and neutral conditions in the reverse order.

Study Record Dates

• First Submitted: November 19, 2021
• First Posted: December 3, 2021
• Study Start: February 7, 2022
• Primary Completion: June 1, 2022
• Study Completion: September 1, 2022
• Last Updated: March 24, 2022

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)