Inflammatory Biomarkers and Brain Metabolites, a Study Based on Magnetic Resonance Spectroscopy

NCT03052855 | Completed

• 2 other identifiers: UF97412016-A01267-44
• Study Type: interventional
• Target: 69
• Locations: 1 country
• Sites: 1

Brief Summary

Suicidal behaviors (SB) are a major health problem in France : 10 000 suicides and 220 000 suicide attempts every year. SB management is therefore a major public health issue. Evidence associated dysregulation of the serotonergic system and the hypothalamic-pituitary-adrenal axis to vulnerability to SB. Recent data point to linke these abnormalities with neuroinflammatory clues, glutamatergic function and neuronal plasticity. There is a need to better understand the physiopathology and develop diagnostic and therapeutic tools in SB. The investigators hypothesize that increased peripheral biomarkers of inflammation would correlate to a disturbance of the cerebral metabolites, such as glutamate and NAA, especially in suicidal patients. Our aim is to compare rates of cerebral metabolites, in particular the complex glutamine/glutamate, in cerebral areas involved in suicidal vulnerability (the anterior cingulate cortex and the orbito-frontal cortex) between person with unipolar disorder with and without suicidal attempt.

Conditions

Depression

Keywords

Psychiatry; Suicidal behaviour; Cerebral metabolites; MRI; Inflammatory markers

Outcome Measures

Primary Outcomes (1)

• Glutamine (Glu) and Glutamate (Glx) levels

  Levels of Glu/Glx in the anterior cingulate cortex and the orbitofrontal cortex between the depressed patients with and without suicide attempt

  At V1 (the day of the MRI)

Secondary Outcomes (13)

• Link between rate of Interleukin 1, 2, 4, 5, 6, 7, 9, 10, 13 and suicide attempt

  At V1 (the day of the MRI)

• Level of N-Acetyl-Aspartate (NAA)

  At V1 (the day of the MRI)

• Level of Choline (Cho)

  At V1 (the day of the MRI)

• Level of Myo-inositol (Myo)

  At V1 (the day of the MRI)

• Level of Creatinine (Cr)

  At V1 (the day of the MRI)

Study Arms (1)

Participants

OTHER

All the participants of the 3 groups (depressed patients with suicide attempt, depressed patients without suicide attempt, healthy volunteers) will have to realize a MRI and biological samples.

Other: Magnetic Resonance Imaging (MRI) and biological samples

Interventions

Magnetic Resonance Imaging (MRI) and biological samples OTHER

Participants will have to do a MRI and biological samples.

Participants

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Having signed informed consent
• Able to understand nature, aims and methodology of the study
• Suicidal patient with suicide attempt :
• Persistent depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders - V (DSM-V) criteria, and evaluated by the Mini International Neuropsychiatric Interview (MINI)
• Hamilton Depression Scale \> 7
• Suicide attempt \< 1 week
• Suicidal patient without suicide attempt :
• Persistent depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders - V (DSM-V) criteria, and evaluated by the Mini International Neuropsychiatric Interview (MINI)
• Hamilton Depression Scale \> 7
• No history of suicide attempt
• Healthy volunteers :
• No psychiatric history
• No history of suicide attempt

You may not qualify if:

• Actual somatic, neurological or inflammatory pathology (C-Reactive Protein \> 10mg/L)
• Traumatic brain injury with loss of consciousness
• Antibiotic treatment or anti-inflammatory treatment
• Actual toxic abuse according to DSM-V (except tobacco and alcohol)
• Actual or passed history of psychotic disorder
• Patient on protective measures (guardianship or trusteeship)
• Deprived of liberty subject (judicial or administrative decision)
• Pregnant women or breastfeeding
• Contraindications to MRI scan

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

Montpellier Hospital University

Montpellier, 34295, France

Location

Related Publications (1)

• Olie E, Clain G, Malestroit M, Fiedos D, Cognasse F, Deverdun J, Bars EL, Courtet P. Association of Suicidal Status, Inflammation Markers, and Resting-State Functional Activity and Connectivity in Patients With Major Depressive Disorder. J Clin Psychiatry. 2024 Jun 26;85(3):23m15148. doi: 10.4088/JCP.23m15148.

  PMID: 39874064 DERIVED

MeSH Terms

Conditions

Depression

Interventions

Magnetic Resonance Spectroscopy

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Spectrum Analysis; Chemistry Techniques, Analytical; Investigative Techniques

Study Officials

• Frédéric COPPOLA, MD

  Montpellier Hospital University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 31, 2017
• First Posted: February 14, 2017
• Study Start: February 1, 2017
• Primary Completion: November 29, 2017
• Study Completion: November 29, 2017
• Last Updated: December 21, 2021

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)