Malignant Hyperthermia in Czech Republic: Description of the Biggest Slavonic Group of Patients Investigated for Risk of Malignant Hyperthermia

NCT05036148 | Completed

• 1 other identifier: KDAR FN Brno MH
• Study Type: observational
• Target: 286
• Locations: 1 country
• Sites: 1

Brief Summary

The Academic centre for Malignant Hyperthermia of Masaryk University (ACMHMU) was established in 2021 in Brno, Czech Republic and consists of four academic departments of Medical Faculty of Masaryk University in two tertiary university hospitals, University Hospital Brno and St. Anne Faculty Hospital. These departments collaborated and operated since 2002 and since 2019 is Brno one of the of centre of EMHG (www.emhg.org). Aim of this study was to describe the Czech and Slovak (CZ-SK) cohort of MHS patients, the biggest Slavonic MHS cohort known by now, and to fill the knowledge gap about the Slavonic population in perspective of MH.

Conditions

Malignant Hyperthermia

Keywords

Malignant Hyperthermia

Outcome Measures

Primary Outcomes (1)

• prevalence of MH in our cohort of patients

  Data registry will be screened for positive MH results

  20 years retrospectively

Secondary Outcomes (2)

• prevalence of occurrence diagnostic variants in MHS group of patients.

  20 years retrospectively

• prevalence of each found diagnostic variant in our Czech-and-Slovak cohort of patients.

  20 years retrospectively

Study Arms (1)

Patients indicated for MH screening

Patients referred to MH center for MH diagnostic

Other: Data analysis

Interventions

Data analysis OTHER

MH registry data will be screened for MH positive diagnosis

Patients indicated for MH screening

Eligibility Criteria

• Age: 1 Month - 99 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patient indiaceted to MH centre for MH diagnostic

You may qualify if:

• Patients indicated to MH center for MH diagnostic

You may not qualify if:

• conditions clearly not related to MH, e.g. neuromuscular diseases
• syndromes without MH risk; anaesthetic complications without MH symptoms, e.g. prolongated awakening due to deficit of cholinesterase
• probands with missing data
• probands with yet not closed MH diagnostic process (waiting for genetics or IVCT, myopatic patients without MH diagnostic variant where the IVCT was not recommended because of its invasivity)
• non-compliant probands, who refused the diagnostic process.

Sponsors & Collaborators

• Brno University Hospital: lead
• Masaryk University: collaborator

Study Sites (1)

Brno University Hospital - Academic Centre for Malignant Hyperthermia of Masaryk University Brno

Brno, South Moravian, 62500, Czechia

Location

MeSH Terms

Conditions

Malignant Hyperthermia

Condition Hierarchy (Ancestors)

Intraoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Postoperative Complications; Hyperthermia; Body Temperature Changes; Signs and Symptoms

Study Officials

• Petr Stourac, prof. MD., Ph.D.

  Department of paediatric anaesthesia and intensive care

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: July 27, 2021
• First Posted: September 5, 2021
• Study Start: September 1, 2021
• Primary Completion: December 31, 2021
• Study Completion: December 31, 2021
• Last Updated: April 15, 2022

Record last verified: 2022-04

Locations

CZ (1)