MCR Syndrome in Quebec : Results From NuAge Study

NCT05046275 | Active Not Recruiting

• 1 other identifier: 2021-245
• Study Type: observational
• Target: 1,741
• Locations: 1 country
• Sites: 1

Brief Summary

The overall objective of the proposal is to examine the epidemiology of the newly reported "motoric cognitive risk" (MCR) syndrome, which is a pre-dementia syndrome combining subjective cognitive complaint (i.e.; memory complaint) with objective slow gait speed, in the Quebec elderly population. Cognition and locomotion are two human abilities controlled by the brain. Their decline is highly prevalent with physiological and pathological aging, and is greater than the simple sum of their respective prevalence, suggesting a complex age-related interplay between cognition and locomotion. Both declines in cognition and locomotion are associated, furthermore the temporal nature of their association has been unclear for a long time. Recently, a systematic review and meta-analysis has provided evidence that poor gait performance predicts dementia and, in particular, has demonstrated that MCR syndrome is a pre-dementia syndrome, suggesting that low gait performance is the first symptom of dementia. The uniqueness of MCR syndrome is that it does not rely on a complex evaluation or laboratory investigations. Indeed, this syndrome combined subjective cognitive complaint and objective slow gait speed, and is easy to apply in population-based settings. Prevalence and incidence of MCR syndrome, as well as its association with incidence of cognitive decline and impairment, have never been reported in Canada. Nutrition as a determinant of successful aging: The Quebec longitudinal Study (the NuAge study) is a Quebec population-based observational cohort study performed in healthy older community-dwellers adults which provides a unique opportunity to: 1) obtain reliable estimates of MCR syndrome prevalence and incidence, 2) determine the distribution of clinical and biological (blood biomarkers and genetic) characteristics associated with MCR syndrome, 3) examine the association of MCR syndrome and its biological characteristics with cognitive decline and incidence of cognitive impairment in the Quebec elderly population.

Conditions

Motoric Cognitive Risk Syndrome; Aging Disorder

Outcome Measures

Primary Outcomes (1)

• prevalence of MCR syndrome

  Diagnosis of MCR syndrome following Verghese et al. criteria

  3 years

Secondary Outcomes (7)

• Cognitive decline and impairment

  3 years

• Covariates

  3 years

• Covariates

  3 years

• Covariates

  3 years

• Covariates

  3 years

Study Arms (2)

MCR syndroms

Summarize of participants' characteristics using means and standard deviations or frequencies and percentages First, prevalence of MCR syndrome will be determined by classifying participants into MCR and non-MCR syndrome groups. Second, between-group comparisons of participants' characteristics will be performed using unpaired t-test, Mann-Whitney, analysis of variance with LSD correction or Chi-square test, as appropriate. Third, multiple regressions will be performed to examine the association between MCR syndrome (dependent variable) and cardio-vascular risk factors and/or diseases (independent variables) adjusted on participants' characteristics. Fourth, the incidence of MCR syndrome during the follow-up period of NuAge study will be reported. Fifth, regression will be performed to examine the association between MCR syndrome (dependent variable) and cognitive decline as well cognitive impairment (independent variables, separated model) adjusted on participants' characteristics.

Other: Data analysis

Non MCR syndroms

Summarize of participants' characteristics using means and standard deviations or frequencies and percentages First, prevalence of MCR syndrome will be determined by classifying participants into MCR and non-MCR syndrome groups. Second, between-group comparisons of participants' characteristics will be performed using unpaired t-test, Mann-Whitney, analysis of variance with LSD correction or Chi-square test, as appropriate. Third, multiple regressions will be performed to examine the association between MCR syndrome (dependent variable) and cardio-vascular risk factors and/or diseases (independent variables) adjusted on participants' characteristics. Fourth, the incidence of MCR syndrome during the follow-up period of NuAge study will be reported. Fifth, regression will be performed to examine the association between MCR syndrome (dependent variable) and cognitive decline as well cognitive impairment (independent variables, separated model) adjusted on participants' characteristics.

Other: Data analysis

Interventions

Data analysis OTHER

No intervention, data analysis only

MCR syndroms; Non MCR syndroms

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All included participants of NuAge Study were healthy and, in particular, they were cognitively intact at baseline and had no mobility disability.

You may qualify if:

• All included participants of NuAge Study

You may not qualify if:

• no information about cognitive complaint in NuAge database
• no measure of walking speed in NuAge database
• no follow-up completed in NuAge database

Sponsors & Collaborators

• Centre integre universitaire de sante et de services sociaux du Centre-Sud-de-l'Île-de-Montréal: lead

Study Sites (1)

CRIUGM

Montreal, Quebec, H3W 1W5, Canada

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD, Senior researcher, Director of laboratory

Study Record Dates

• First Submitted: September 8, 2021
• First Posted: September 16, 2021
• Study Start: November 3, 2020
• Primary Completion: November 2, 2025
• Study Completion: December 1, 2025
• Last Updated: February 23, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)