The Medical Management in Patients Exposed to Weapons of Mass Destruction

NCT05026645 | Enrolling By Invitation DMC

• 1 other identifier: 2020-2561
• Study Type: observational
• Target: 1,000
• Locations: 6 countries
• Sites: 15

Brief Summary

Observation study measuring medical response in contaminated environment.

Conditions

Chemical Injury; Chemicals; Intoxication; Acute Respiratory Distress Syndrome; Distress Respiratory Syndrome; Medical Emergencies

Keywords

CBRNE Defence; Acute Settings; Pre-Hospital Settings; Decontamination; Protection; Respiratory Insults; Treatments

Outcome Measures

Primary Outcomes (1)

• Intervention and location

  The percentage of patients to whom the World Health Organization's healthcare guidelines were applied without any delay (i.e.: during a medical extraction/evacuation)

  At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation).

Secondary Outcomes (4)

• Contamination is under-control due to efficient protective measures applied during a medical extraction/evacuation

  At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation).

• Contamination under-control due to efficient decontamination measures applied during a medical extraction/evacuation

  At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation).

• Deterioration of the patient's health condition due to compromised means of protection

  At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation).

• Deterioration of the patient's health condition due to compromised means of decontamination

  At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation).

Study Arms (8)

adult inflicted by a CBRNE weapon

Part of the Population is being studied includes any individual who was affected by CBRNE attacks and needed an intervention of the healthcare system.

Procedure: Clinical interventions performed in acute settings (contaminated environment); Procedure: Protection (clinician and patient); Procedure: Decontamination (clinician and patient)

Infant inflicted by a CBRNE weapon

Part of the population is being studied includes any individual who was affected by CBRNE attacks and needed an intervention of the healthcare system.

Procedure: Clinical interventions performed in acute settings (contaminated environment); Procedure: Protection (clinician and patient); Procedure: Decontamination (clinician and patient)

Women inflicted by a CBRNE weapon

Part of the Population is being studied includes any individual who was affected by CBRNE attacks and needed an intervention of the healthcare system.

Procedure: Clinical interventions performed in acute settings (contaminated environment); Procedure: Protection (clinician and patient); Procedure: Decontamination (clinician and patient)

Men inflicted by a CBRNE weapon

Part of the Population is being studied includes any individual who was affected by CBRNE attacks and needed an intervention of the healthcare system.

Procedure: Clinical interventions performed in acute settings (contaminated environment); Procedure: Protection (clinician and patient); Procedure: Decontamination (clinician and patient)

Elderly inflicted by a CBRNE weapon

Part of the Population is being studied includes any individual who was affected by CBRNE attacks and needed an intervention of the healthcare system.

Procedure: Clinical interventions performed in acute settings (contaminated environment); Procedure: Protection (clinician and patient); Procedure: Decontamination (clinician and patient)

Diagnosed with chronic disease(s) inflicted by a CBRNE weapon

Part of the Population is being studied includes any individual who was affected by CBRNE attacks and needed an intervention of the healthcare system.

Procedure: Clinical interventions performed in acute settings (contaminated environment); Procedure: Protection (clinician and patient); Procedure: Decontamination (clinician and patient)

Clinician (adult) whom performs his/her clinical interventions

Clinician (adult) whom performs his/her clinical interventions while integrating competences in protections and decontamination. Part of the Population is being studied includes any individual who was affected by CBRNE attacks and needed an intervention of the healthcare system. This is the case of when the clinician is required to ensure safety toward his/her patient while performing his/her interventions \& procedures.

Procedure: Clinical interventions performed in acute settings (contaminated environment); Procedure: Protection (clinician and patient); Procedure: Decontamination (clinician and patient)

Clinician (adult) injured by duties circumstances

Part of the Population is being studied includes any individual who was affected by CBRNE attacks and needed an intervention of the healthcare system. This is the case of when the clinician becomes inflicted by a CBRNE weapon while intervening toward contaminated patient due to any failure in protection and decontamination.

Procedure: Clinical interventions performed in acute settings (contaminated environment); Procedure: Protection (clinician and patient); Procedure: Decontamination (clinician and patient)

Interventions

Clinical interventions performed in acute settings (contaminated environment) PROCEDURE

Any clinical intervention performed on the patient inflicted by at least one of Chemical, Biological, Radiological, Nuclear, Explosive (CBRNE) weapons in acute settings (from the incident site up to his/her admission to the clean zone of a emergency room or its equivalent (ie.: walking clinic).

Clinician (adult) injured by duties circumstances; Clinician (adult) whom performs his/her clinical interventions; Diagnosed with chronic disease(s) inflicted by a CBRNE weapon; Elderly inflicted by a CBRNE weapon; Infant inflicted by a CBRNE weapon; Men inflicted by a CBRNE weapon; Women inflicted by a CBRNE weapon; adult inflicted by a CBRNE weapon

Protection (clinician and patient) PROCEDURE

As interrelated competence of the clinical intervention, any protection procedure and capability applied on the patient inflicted by at least one of Chemical, Biological, Radiological, Nuclear, Explosive (CBRNE) weapons in acute settings (from the incident site up to his/her admission to the clean zone of a emergency room or its equivalent (ie.: walking clinic). Concerning the clinician, the protection implied for his/her own safety and for the patient to whom she/he was in closed/contact with.

Clinician (adult) injured by duties circumstances; Clinician (adult) whom performs his/her clinical interventions; Diagnosed with chronic disease(s) inflicted by a CBRNE weapon; Elderly inflicted by a CBRNE weapon; Infant inflicted by a CBRNE weapon; Men inflicted by a CBRNE weapon; Women inflicted by a CBRNE weapon; adult inflicted by a CBRNE weapon

Decontamination (clinician and patient) PROCEDURE

As interrelated competence of the clinical intervention and protection, any decontamination procedure and capability applied on the patient inflicted by at least one of Chemical, Biological, Radiological, Nuclear, Explosive (CBRNE) weapons in acute settings (from the incident site up to his/her admission to the clean zone of a emergency room or its equivalent (ie.: walking clinic). Concerning the clinician, the protection implied for his/her own safety and for the patient to whom she/he was in closed/contact with. This crucial step is usually expected prior the patient's transfer into a clean zone like the emergency room or its equivalent.

Clinician (adult) injured by duties circumstances; Clinician (adult) whom performs his/her clinical interventions; Diagnosed with chronic disease(s) inflicted by a CBRNE weapon; Elderly inflicted by a CBRNE weapon; Infant inflicted by a CBRNE weapon; Men inflicted by a CBRNE weapon; Women inflicted by a CBRNE weapon; adult inflicted by a CBRNE weapon

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Population is being studied includes any individual who was affected by CBRNE attacks and needed an intervention of the healthcare system.

You may qualify if:

• i. a CBRNE attack caused at least one casualty who required the assistance of the participating health care system (e.g.: physicians, nurses, paramedics and other health-care specialists of a medical facility) during a medical extraction from the incident site until admission to a medical facility;
• ii. Patients are eligible if they were exposed to the CBRNE attack;
• iii. Medical information concerning the CBRNE exposures, even if partial, is accessible to health care professionals for the purposes of filling out the online case report form (eCRF);
• iv. Participants must be able to complete the online case report form in English; and
• v. The approval of an Ethics Review Board is obtained by each medical centre participant.

Sponsors & Collaborators

• St. Justine's Hospital: lead
• Quebec Heart and Lung Institute, Quebec City, Canada: collaborator
• Sorbonne University: collaborator
• Medical Intelligence CBRNE inc.; Quebec City, Canada: collaborator
• Department of Intensive Care Medicine, Tokyo, Japan: collaborator
• Centre for Defence and Security Studies, University of Manitoba, Winnipeg, Canada: collaborator
• Biomedical Telematics Laboratory, Quebec Respiratory Health Research Network, Sherbrooke, Canada: collaborator
• Tokyo University: collaborator
• Tokyo Women's Medical University: collaborator
• University of Maryland, College Park: collaborator

Study Sites (15)

Director, Unconventional Weapons & Technology Division, National Consortium for the Study of Terrorism and Responses to Terrorism University of Maryland

College Park, Maryland, 20740, United States

Location

Centre for Defence and Security Studies, University of Manitoba

Winnipeg, Manitoba, R3T 2N2, Canada

Location

Royal Canadian Medical Corps

Ottawa, Ontario, K1A0K2, Canada

Location

École de Technologie Supérieure Université du Québec

Montreal, Quebec, H3C 1K3, Canada

Location

Research Center of the CHU St-Justine, University of Montreal

Montreal, Quebec, H3T 1C5, Canada

Location

Research Centre, Quebec Heart and Lung Institute, Laval University

Québec, Quebec, G1V 4G5, Canada

Location

Medical Intelligence CBRNE Inc.

Québec, Quebec, G1V0C8, Canada

Location

Biomedical Telematics Laboratory Platform of the Quebec Respiratory Health Research Network

Sherbrooke, Quebec, J1K 2R1, Canada

Location

University of Finance and Administration Department of Criminology and Forensic Disciplines

Prague, Prague, 10100, Czechia

Location

Sorbonne University

Paris, Île-de-France Region, France

Location

Tokyo Women's Medical University, Department of Intensive Care Medicine

Tokyo, Shinjuku-ku, Japan

Location

Department of Critical care, Miyagi Children's Hospital

Tokyo, Japan

Location

Department of Disaster Medical Management, The University of Tokyo Hospital

Tokyo, Japan

Location

Surrey and Sussex Healthcare NHS Trust

Surrey Quays, Redhill, RH1 5RH, United Kingdom

Location

CBRNE World Journal

Winchester, SO23 8UT, United Kingdom

Location

Related Publications (1)

• Bourassa S, Noebert D, Dauphin M, Rambaud J, Kawaguchi A, Leger F, Beijer D, Fortier Y, Dligui M, Ivanovski H, Simard S, Jouvet P, Leclerc J. Acute care for patients exposed to a chemical attack: protocol for an international multicentric observational study. BMJ Open. 2022 Sep 29;12(9):e065015. doi: 10.1136/bmjopen-2022-065015.

  PMID: 36175098 DERIVED

MeSH Terms

Conditions

Respiratory Distress Syndrome; Pulmonary Atelectasis

Interventions

Decontamination

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Respiration Disorders

Intervention Hierarchy (Ancestors)

Public Health Practice; Public Health; Environment and Public Health

Study Officials

• Stephane Bourassa

  Ste-Justine's Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief of CBRNE Team

Study Record Dates

• First Submitted: August 18, 2021
• First Posted: August 30, 2021
• Study Start: October 1, 2020
• Primary Completion (Estimated): November 1, 2036
• Study Completion (Estimated): December 1, 2036
• Last Updated: October 1, 2025

Record last verified: 2025-09

Locations

FR (1); JP (3); US (1); GB (2); CZ (1); CA (7)